Results 101 to 110 of about 5,872,931 (280)

Examining impact of vapor-induced crosslinking duration on dynamic mechanical and static mechanical characteristics of silane-water crosslinked polyethylene compound

open access: yesPolymer Testing, 2021
Silane-crosslinked polyethylene (Si-XLPE) compounds are widely used cable insulation materials, cured by water as the crosslinking inducer. Herein, an attempt was made to evaluate the alterations of dynamic mechanical and static mechanical properties of ...
Navid Mostofi Sarkari   +2 more
doaj  

Genomics‐led approach to drug testing in models of undifferentiated pleomorphic sarcoma

open access: yesMolecular Oncology, EarlyView.
GA text Genomic data from undifferentiated pleomorphic sarcoma patients and preclinical models were used to inform a targeted drug screen. Selected compounds were tested in 2D and 3D cultures of UPS cell lines. A combination of trametinib and infigratinib was synergistic in the majority of UPS cell lines tested, which was further confirmed in an ex ...
Piotr J. Manasterski   +19 more
wiley   +1 more source

A nucleotide‐independent, pan‐RAS‐targeted DARPin elicits anti‐tumor activity in a multimodal manner

open access: yesMolecular Oncology, EarlyView.
We report a Designed Ankyrin Repeat Protein that binds and inhibits RAS proteins, which serve as central cell signaling hubs and are essential for the progression of many cancers. Its unique feature is that it does not discriminate between different RAS isoforms or mutations and is capable of binding to RAS in both its active (GTP‐bound) and inactive ...
Jonas N. Kapp   +13 more
wiley   +1 more source

Investigation of Release Kinetics of DOX from Polydopamine Nanocapsules Prepared by Hard Template Method

open access: yesMacromolecular Materials and Engineering
Development of smart drug delivery systems (DDSs) for effective delivering drugs to targeted areas and achieving controlled drug release (CDR) is critical for cancer chemotherapy.
Elahe Abdollahi   +4 more
doaj   +1 more source

Factors impacting human-perceived visual quality on television displays

open access: yesFrontiers in Neuroscience
There is a growing interest in understanding the factors that influence a user's perception and preferences for video quality. This study specifically focuses on how various factors, including video content, display settings, viewer characteristics, and ...
Eddie Pei   +3 more
doaj   +1 more source

Simultaneous inhibition of TRIM24 and TRIM28 sensitises prostate cancer cells to antiandrogen therapy, decreasing VEGF signalling and angiogenesis

open access: yesMolecular Oncology, EarlyView.
TRIM24 and TRIM28 are androgen receptor (AR) coregulators which exhibit increased expression with cancer progression. Both TRIM24 and TRIM28 combine to influence the response of castrate‐resistant prostate cancer (CRPC) cells to AR inhibitors by mediating AR signalling, regulation of MYC and upregulating VEGF to promote angiogenesis. Castrate‐resistant
Damien A. Leach   +8 more
wiley   +1 more source

Ocean color imagery: Coastal zone color scanner [PDF]

open access: yes
Investigations into the feasibility of sensing ocean color from high altitude for determination of chlorophyll and sediment distributions were carried out using sensors on NASA aircraft, coordinated with surface measurements carried out by oceanographic ...
Hovis, W. A.
core   +1 more source

Tumor clusters with divergent inflammation and human retroelement expression determine the clinical outcome of patients with serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Analysis of treatment‐naïve high‐grade serous ovarian carcinoma (HGSOC) and control tissues for ERVs, LINE‐1 (L1), inflammation, and immune checkpoints identified five clusters with diverse patient recurrence‐free survivals. An inflammation score was calculated and correlated with retroelement expression, where one novel cluster (Triple‐I) with high ...
Laura Glossner   +6 more
wiley   +1 more source

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