Results 111 to 120 of about 679,153 (291)

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Do the Spectra of Soft X-ray Transients Reveal Bulk Motion Inflow Phenomenon?

, 1999
We present our analysis of the high-energy radiation from black hole (BH) transients, using archival data obtained primarily with RXTE observatory, and a comprehensive test of the bulk motion Comptonization (BMC) model for the high-soft state continuum ...
Borozdin, Konstantin, Revnivtsev, Mikhail, Shrader, Chris, Titarchuk, Lev, Trudolyubov, Sergey   +4 more
core   +1 more source

Consistent Video Colorization via Palette Guidance

Colorization is a traditional computer vision task and it plays an important role in many time-consuming tasks, such as old film restoration. Existing methods suffer from unsaturated color and temporally inconsistency. In this paper, we propose a novel pipeline to overcome the challenges.
Wang, Han, Zhang, Yuang, Zhang, Yuhong, Lu, Lingxiao, Song, Li   +4 more
openaire   +2 more sources

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

PYRENE MORPHOLOGY OF THREE SPECIES OF Byrsonima Rich. ex Kunth (Malpighiaceae)1

Revista Árvore, 2015
The species of the genus Byrsonima Rich. ex Kunth are of great medicinal and economic importance, but they are still poorly studied with respect to their propagules.
Cylles Zara dos Reis Barbosa, Maria Silvia de Mendonça, Rodrigo Schütz Rodrigues   +2 more
doaj   +1 more source

FHSI: Toward More Human-Consistent Color Representation

Journal of Advanced Computational Intelligence and Intelligent Informatics, 2016
In this paper, we propose a novel approach toward the development of a perceptual color space, FHSI, which stands for “Fuzzy HSI," because it is based on the fuzzification of the well-known HSI color space. FHSI represents a set of fuzzy colors obtained by partitioning the gamut of feasible colors in the HSI model corresponding to standardized ...
Pakizar Shamoi, Atsushi Inoue, Hiroharu Kawanaka   +2 more
openaire   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Improved dynamic CT angiography visualization by flow territory masking

Brain Circulation, 2015
Backgound and Purpose: Computerized tomography (CT) perfusion (or CTP) source images from CT scanners with small detector widths can be used to create a dynamic CT angiogram (CTA) similar to digital subtraction angiography (DSA).
Søren Christensen, Bruce Campbell, Maarten G Lansberg, Jacqui Hislop-Jambrich, Stephen Davis, Patricia Desmond, Mark Parsons   +6 more
doaj   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Development of a Sensory Method to Detect Food-Elicited Emotions Using Emotion-Color Association and Eye-Tracking

Foods, 2019
Studying consumers’ implicit emotions has been always described as a difficult and a complicated mission due to the emotions being of a non-cognitive nature.
Diana Ismael, Angelika Ploeger
doaj   +1 more source