Results 71 to 80 of about 1,169,824 (282)

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

Using Eye Tracking to Explore the Guidance and Constancy of Visual Variables in 3D Visualization

ISPRS International Journal of Geo-Information, 2017
An understanding of guidance, which means guiding attention, and constancy, meaning that an area can be perceived for what it is despite environmental changes, of the visual variables related to three-dimensional (3D) symbols is essential to ensure rapid
Bing Liu, Weihua Dong, Liqiu Meng
doaj   +1 more source

Characterization of therapeutic antibodies targeting lymphatic and vascular resistance factor for the treatment of hypervascularized and highly metastatic cancers

Molecular Oncology, EarlyView.
LVRF (lymphatic and vascular resistance factor) is a VEGFA splice variant upregulated in response to anti‐angiogenic therapy that fosters tumor adaptation through enhanced vascularization, lymphangiogenesis, and metastatic dissemination. Targeting LVRF with fully human neutralizing antibodies disrupts these processes and limits resistant tumor growth ...
Marion David, Arthur Karaulic, Audrey Bennetot, Clémence Fournier, Quentin Odet, Arthur Gouraud, Isabelle Bourget, Cédric Gaggioli, Sandy Giuliano, Frédéric Luciano, Olivier Léger, Zaki Sellam, Gilles Pagès   +12 more
wiley   +1 more source

Lightness constancy: Object identity and temporal integration [PDF]

Psihologija, 2008
Studies of lightness constancy typically involve the comparison of two objects of the same shade that have been placed under different illuminations. In this study, we introduce factors such as object identity and immediate prior experience to measure ...
Zdravković Sunčica
doaj   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Pixel and spatial mechanisms of color constancy

, 2010
Color constancy remains an important subject of research on color standards, computer imaging, and human color vision. There are many different theories and algorithms that interpret and predict constancy.
Alessandro Rizzi, A. Rizzi, J. J. McCann, C. E. Parraman, John J. McCann, Carinna E. Parraman   +5 more
core   +1 more source

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

Spatio-Spectral Deep Color Constancy With Multi-Band NIR

IEEE Access
This paper proposes to utilize deep spatio-spectral features for color constancy, while most conventional methods focus on only spatial information of RGB images. We propose a novel color constancy method that exploits multi-band near-infrared (NIR). The
Dong-Keun Han, Jeong-Won Ha, Jong-Ok Kim
doaj   +1 more source

Neural network for color constancy

Informatica, 2000
Summary: Color constancy is the perceived stability of the color of objects under different illuminants. Four-layer neural network for color constancy has been developed. It has separate input channels for the test chip and for the background. Input of network was RGB receptors.
Stanikūnas, Rytis, Vaitkevičius, Henrikas   +1 more
openaire   +3 more sources

Experiments in Sensor Sharpening for

, 2008
Sensor sharpening has been proposed as a method for improving color constancy algorithms but it has not been tested in the context of real color constancy algorithms.
Color Constancy
core