Results 91 to 100 of about 745,348 (331)

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

RGB AND YCbCr COLOR SPACES, STANDARDS AND CONVERSIONS FOR FPGA ENGINEERS

, 2022
Peter Safir
openalex   +1 more source

High Quality Inkjet Printed‐Emissive Nanocrystalline Perovskite CsPbBr₃ Layers for Color Conversion Layer and LEDs Applications [PDF]

, 2022
Giovanni Vescio, Juan Luis Frieiro, Andrés F. Gualdrón‐Reyes, S. Hernández, Iván Mora‐Seró, B. Garrido, A. Cirera   +6 more
openalex   +1 more source

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source

Optical temperature measurement of small droplet array luminous flame in butane diffusion flame

Nihon Kikai Gakkai ronbunshu, 2015
Two color ratio method was applied to measure temperature distributions of a luminous diffusion flame. A small blue butane diffusion flame, 3mm in flame diameter, was used.
Hiroshi ENOMOTO, Syunsuke SAWASAKI, Hirotaka NOZUE, Naoki IWAFUNE, Noboru HIEDA   +4 more
doaj   +1 more source

Theory of quantum frequency translation of light in optical fiber: application to interference of two photons of different color

, 2011
We study quantum frequency translation and two-color photon interference enabled by the Bragg scattering four-wave mixing process in optical fiber. Using realistic model parameters, we computationally and analytically determine the Green function and ...
C. J. McKinstrie, Drummond, Eckstein, Ekert, Gnauck, H. J. McGuinness, Huang, Inoue, Kielpinski, Knill, Kok, M. G. Raymer, Marhic, McGuinness, McGuinness, McKinstrie, McKinstrie, Mehler, Menicucci, Méchin, O’Brien, Rakher, Raymer, Russell, Salehi, Tanzilli, Vandevender, Wasilewski, Wasilewski, Wong   +29 more
core   +1 more source

Resonance‐Based Directional Light Emission from Organic Light‐Emitting Diodes: Comparing Integrated Nanopatterns and Color Conversion Waveguide Gratings [PDF]

, 2022
Janek Buhl, Hannes Lüder, Gitta Bichmann, Tim Nolte, A. Petraru, Martina Gerken   +5 more
openalex   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Detecting agricultural to urban land use change from multi-temporal MSS digital data [PDF]

Conversion of agricultural land to a variety of urban uses is a major problem along the Wasatch Front, Utah. Although LANDSAT MSS data is a relatively coarse tool for discriminating categories of change in urban-size plots, its availability prompts a ...
Jaynes, R. A., Merola, J. A., Ridd, M. K.   +2 more
core   +1 more source