An Extracellular Pore‑Targeting Peptide Defines a Designable Allosteric Site in TRPV2
Structure‐guided peptide engineering yields Depiv2, a highly potent and subtype‐selective TRPV2 inhibitor that binds to the extracellular pore and remodels it into a closed, non‐conductive state. Depiv2 suppresses pathological cardiac hypertrophy, establishing the TRPV2 outer pore as a designable interface for selective peptide modulation.
Aiqin Zhu +7 more
wiley +1 more source
The update of ultrasound techniques in diagnosis of inflammatory bowel disease
Objective: To evaluate the value of conventional abdominal ultrasound and color Doppler in the diagnosis of inflammatory bowel disease (IBD) and its complications.
Mohamed A. Nassef +2 more
doaj +1 more source
High‐density type I collagen promotes glutamine (Gln) accumulation–related ferroptosis of TNBC cells via the spermidine/spermine N1‐acetyltransferase 1 (SAT1)‐ argininosuccinate synthase (ASS1) signaling pathway, thus depriving immune cells of Gln supply and inducing IFN‐γ+ CD8+ T cell exhaustion in the TME.
Jinyan Wang +11 more
wiley +1 more source
Impact of Rapid Thermal Annealing on the Structural and Piezoelectric Properties of AlN Thin Films
Aluminum nitride (AlN) is a biocompatible piezoelectric material suitable for energy harvesting in MEMS resonators. Through rapid thermal annealing, a threshold for CMOS‐compatible processes is established. AlN improved its crystallinity and enhanced the piezoelectric coefficient by ∼160%. Devices show an improvement in the electromechanical properties
Laura Mazón‐Maldonado +7 more
wiley +1 more source
A Bioinspired Underwater Soft Robot for Active Intravesical Liquid Delivery and Mixing
A bioinspired underwater soft robot is reported that integrates an elastic strain energy‐driven soft robotic pump with a programmable flexible magnetic valve, enabling remotely controlled, programmable, and sustained liquid release and mixing. This functionality is enabled by the synergistic integration of elastic strain energy‐driven pumping and ...
Jacob Katona +7 more
wiley +1 more source
The significance of transvaginal ultrasonography and transvaginal color doppler ultrasonography in diagnosis of endometriosis [PDF]
Endometriosis kadınlarda en sık rastlanılan, pelvik ağrı ve infertiliteye neden olan benign jinekolojik rahatsızlıktır. Erken ve doğru teşhis uygun tedaviyi seçmekte esastır ancak endometriosisin teşhisi halen klinik bir problemdir.
Yılmazer, Mehmet +1 more
core +1 more source
Lower limbs valvular insufficiency diagnosed by color-doppler US: variability in the results using the standing or semi-Fowler position and Valsalva maneuver or distal compression [PDF]
Objectives: To determine differences in diagnosis of valvular insufficiency by color doppler ultrasonography in standing or semi-Fowler position and Valsalva maneuver or distal compression.
Federico Guillermo Lubinus Badillo +4 more
doaj
Papel da ultra-sonografia no diagnóstico diferencial dos nódulos de tireóide. [PDF]
Trabalho de Conclusão de Curso - Universidade Federal de Santa Catarina, Centro de Ciências da Saúde, Departamento de Clínica Médica, Curso de Medicina, Florianópolis ...
Neves, Fabrício de Souza
core
ABSTRACT Heterozygous germline variants in CBL disrupt its function as a negative regulator of the Ras/MAPK pathway, classically predisposing to Juvenile myelomonocytic leukemia (JMML) and moyamoya. We describe two affected siblings carrying a paternally inherited CBL variant (c.1210 T> C, p.
Michal Bar‐Hakim +12 more
wiley +1 more source
In this prospective study, we aimed to demonstrate the effects of Extracorporeal Shock Wave Lithotripsy (ESWL) on renal blood flow in patients treated for renal/ ureteral stones.The study group comprised 41 patients (26 males, 15 females, aged between 18-
Nuray Voyvoda +3 more
core +1 more source

