Results 171 to 180 of about 239,050 (309)

Identification of an R2R3-MYB gene regulating tepal background coloration in Tricyrtis sp. [PDF]

Sci Rep
Shinoku Y, Kazama I, Kanemaki Y, Shibuya M, Inagawa K, Ono J, Nakano M, Otani M.   +7 more
europepmc   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Effects of Pinglu Canal Construction on Camouflage in Two Sesarmid Crab Species. [PDF]

Biology (Basel)
Zhai B, Lai F, Lu S, Deng X, Li W, Yang L, Deng C, Wu Z, Huang Y, Wang H, Liao Y, Bu R.   +11 more
europepmc   +1 more source

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source

Fifty Years Later, and We Still Don't Know About Badges of Status. [PDF]

Ecol Evol
Sánchez-Tójar A, D'Amelio PB.
europepmc   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

Associations of MC1R Substitutions With Body Color Variation in a Desert Lizard. [PDF]

Ecol Evol
Tong H, Lin Q, Shi S, Wang K, Guo Y, Brown RP, Jin Y.   +6 more
europepmc   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

Sex-Specific Phenotype-Performance Links: Divergent Correlations Between Morphology, Coloration, and Bite Force in the Mountain Dragon (<i>Diploderma vela</i>). [PDF]

Ecol Evol
Tan S, Li L, Gao W, Shu G, Guo P, Wu Y.
europepmc   +1 more source

Color-Vision [PDF]

Science, 1893
openaire   +5 more sources