Results 11 to 20 of about 692,625 (171)

PPARγ induces PD-L1 expression in MSS+ colorectal cancer cells

OncoImmunology, 2021
Only a small subset of colorectal cancer (CRC) patients benefits from immunotherapies, comprising blocking antibodies (Abs) against checkpoint receptor “programmed-cell-death-1” (PD1) and its ligand (PD-L1), because most cases lack the required ...
Tobias Gutting, Veronika Hauber, Jens Pahl, Kay Klapproth, Wenyue Wu, Ioana Dobrota, Frank Herweck, Juliane Reichling, Laura Helm, Torsten Schroeder, Beifang Li, Philip Weidner, Tianzuo Zhan, Maximilian Eckardt, Johannes Betge, Sebastian Belle, Carsten Sticht, Timo Gaiser, Michael Boutros, Matthias P.A. Ebert, Adelheid Cerwenka, Elke Burgermeister   +21 more
doaj   +1 more source

p53-Independent Inhibition of Proliferation and p21Waf1/Cip1-Modulated Induction of Cell Death by the Antioxidants N-acetylcysteine and Vitamin E

Neoplasia: An International Journal for Oncology Research, 1999
Epidemiological evidence has suggested an association between diets rich in antioxidants and diminished risks of various types of cancer. Proposed mechanisms for protective effects of antioxidants have involved inhibition of free radical-mediated DNA ...
Jennifer L. Nargi, Rajiv R. Ratan, Diane E. Griffin   +2 more
doaj   +1 more source

The LapPath study: Comparison of pathologic outcomes of laparoscopic versus open rectal cancer surgery—A retrospective analysis from a tertiary cancer center in South India

Cancer Research, Statistics, and Treatment, 2023
Background: Total mesorectal excision (TME), which is the mainstay of the surgical management of carcinoma rectum, can either be achieved by open or laparoscopic techniques.
N Aravind, Nizamudheen M Pareekutty, Satheesan Balasubramanian, Akhil P Suresh, Ratheesan Kumbakara   +4 more
doaj   +1 more source

Dysplasia grading of colorectal polyps through CNN analysis of WSI [PDF]

, 2021
Colorectal cancer is a leading cause of cancer death for both men and women. For this reason, histopathological characterization of colorectal polyps is the major instrument for the pathologist in order to infer the actual risk for cancer and to guide further follow-up.
arxiv   +1 more source

Overexpression of the miR-17-92 cluster in colorectal adenoma organoids causes a carcinoma-like gene expression signature

Neoplasia: An International Journal for Oncology Research, 2022
Gain of chromosome arm 13q is one of the most prevalent DNA copy number alterations associated with colorectal adenoma-to-carcinoma progression. The oncogenic miR-17-92 cluster, located at 13q, was found to be overexpressed in colorectal cancer and in ...
Sanne R. Martens-de Kemp, Malgorzata A. Komor, Rosa Hegi, Anne S. Bolijn, Marianne Tijssen, Florence L.M. de Groen, Annekatrien Depla, Monique van Leerdam, Gerrit A. Meijer, Remond J.A. Fijneman, Beatriz Carvalho   +10 more
doaj  

Metformin is a metabolic modulator and radiosensitiser in rectal cancer

Frontiers in Oncology, 2023
Resistance to neoadjuvant chemoradiation therapy, is a major challenge in the management of rectal cancer. Increasing evidence supports a role for altered energy metabolism in the resistance of tumours to anti-cancer therapy, suggesting that targeting ...
Croí E. Buckley, Croí E. Buckley, Rebecca M. O’Brien, Rebecca M. O’Brien, Timothy S. Nugent, Timothy S. Nugent, Timothy S. Nugent, Noel E. Donlon, Noel E. Donlon, Noel E. Donlon, Noel E. Donlon, Fiona O’Connell, Fiona O’Connell, John V. Reynolds, John V. Reynolds, Adnan Hafeez, Diarmuid S. O’Ríordáin, Robert A. Hannon, Paul Neary, Reza Kalbassi, Brian J. Mehigan, Brian J. Mehigan, Paul H. McCormick, Paul H. McCormick, Cara Dunne, Cara Dunne, Michael E. Kelly, Michael E. Kelly, John O. Larkin, John O. Larkin, Jacintha O’Sullivan, Jacintha O’Sullivan, Niamh Lynam-Lennon, Niamh Lynam-Lennon   +33 more
doaj   +1 more source

How to improve the adenoma detection rate in colorectal cancer screening? Clinical factors and technological advancements

Archives of Medical Science, 2019
Introduction Colonoscopy has been widely regarded as the gold standard in colorectal cancer (CRC) screening. Within recent years different endoscopic imaging techniques have been introduced to improve the quality of colonoscopy.
Maciej Matyja, Artur Pasternak, Mirosław Szura, Michał Wysocki, Michał Pędziwiatr, Kazimierz Rembiasz   +5 more
doaj   +1 more source

Surgical resection and survival outcomes in metastatic young adult colorectal cancer patients

Cancer Medicine, 2021
Background The incidence of colorectal cancer in adults younger than age 50 has increased with rates expected to continue to increase over the next decade.
Nina D. Arhin, Chan Shen, Christina E. Bailey, Lea K. Matsuoka, Alexander T. Hawkins, Andreana N. Holowatyj, Kristen K. Ciombor, Michael B. Hopkins, Timothy M. Geiger, Audrey E. Kam, Marc T. Roth, Cody M. Lebeck Lee, Michael Lapelusa, Arvind Dasari, Cathy Eng   +14 more
doaj   +1 more source

Prevalence of Lung Metastases among 19,321 Metastatic Colorectal Cancer Patients in Eight Countries of Europe and Asia

Current Oncology, 2021
Background: Colorectal cancer is one of the most common malignancies in the Western world, and is responsible for about 10% of annual cancer-related deaths. Especially for UICC stage IV, the probability of survival is significantly reduced.
Markus S. Jördens, Simon Labuhn, Tom Luedde, Laura Hoyer, Karel Kostev, Sven H. Loosen, Christoph Roderburg   +6 more
doaj   +1 more source

Antiproliferative Effect of Clitoria ternatea Ethanolic Extract against Colorectal, Breast, and Medullary Thyroid Cancer Cell Lines

Separations, 2022
Clitoria ternatea is a native plant with medicinal and nutritive significance in Asia. The goal of this work was to examine the antiproliferative role of Clitoria ternatea against colorectal (HCT116), breast (MCF-7), and thyroid (TT) cancer cell lines at
Salha M. ALshamrani, Fatmah A. Safhi, Maysa A. Mobasher, Rasha M. Saleem, Afaf Alharthi, Dalal Sulaiman Alshaya, Nabil S. Awad   +6 more
doaj   +1 more source