Results 131 to 140 of about 1,124,548 (306)

A systematic review of the association between circulating concentrations of C reactive protein and cancer.

, 2007
The objective of this study was to review and summarise the published evidence for an association between circulating concentrations of C reactive protein (CRP) and cancer through a systematic review. 90 discrete studies were identified.
Ebrahim, Shah, Heikkilä, Katriina, Lawlor, Debbie A   +2 more
core   +1 more source

End-to-end prognostication in colorectal cancer by deep learning: a retrospective, multicentre study

, 2023
Xiaofeng Jiang, Michael Hoffmeister, Hermann Brenner, Hannah Sophie Muti, Tanwei Yuan, Sebastian Foersch, Nicholas P. West, Alexander Brobeil, Jitendra Jonnagaddala, Nicholas J. Hawkins, Robyn L. Ward, Titus J. Brinker, Oliver Lester Saldanha, Jia Ke, Wolfram Müller, Heike I. Grabsch, Philip Quirke, Daniel Truhn, Jakob Nikolas Kather   +18 more
openalex   +1 more source

α‐Mangostin‐encapsulated PLGA nanoparticles inhibit colorectal cancer growth by inhibiting Notch pathway [PDF]

, 2020
Varun C. Boinpelly, Raj Kumar Verma, Sudesh Srivastav, Rohit Srivastava, Sharmila Shankar   +4 more
openalex   +1 more source

Establishment of a coculture system for Porphyromonas gingivalis and head and neck squamous cell carcinoma using spheroid culture and LATS inhibition

FEBS Open Bio, EarlyView.
We established a spheroid coculture system enabling viable Porphyromonas gingivalis–HNSCC interactions under normoxic conditions. Inhibition of LATS1/2 maintains tumor cells in an undifferentiated state, which may promote spheroid growth and create a more permissive environment for bacterial persistence.
Yurika Nakajima, Shogo Okazaki, Muneaki Tamura, Shuichi Sato, Kenichi Imai   +4 more
wiley   +1 more source

Pathogenic Neurofibromatosis type 1 gene variants in tumors of non‐NF1 patients and role of R1276

FEBS Open Bio, EarlyView.
Somatic variants of the neurofibromatosis type 1 (NF1) gene occur across neoplasms without clinical manifestation of the disease NF1. We identified emerging somatic pathogenic NF1 variants and hotspots, for example, at the arginine finger 1276. Those missense variants provide fundamental information about neurofibromin's role in cancer.
Mareike Selig, Swanhild Lohse, Sara Elahi, Nils Hartmann, Stefanie Deckert, Shutian Si, Alexander Desuki, Anja Harder   +7 more
wiley   +1 more source

KRAS Genotyping of Paraffin-Embedded Colorectal Cancer Tissue in Routine Diagnostics [PDF]

, 2009
Wilko Weichert, Christiane Schewe, Annika Lehmann, Christine Sers, Carsten Denkert, Jan Budczies, Albrecht Stenzinger, Hans Ludwig Joos, Olfert Landt, Volker Heiser, Christoph Röcken, Manfred Dietel   +11 more
openalex   +1 more source

Engineering tandem VHHs to target different epitopes to enhance antibody‐dependent cell‐mediated cytotoxicity

FEBS Open Bio, EarlyView.
Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu, Hao Jiang, Limin Chen, Fulai Zhou, Ying Jin, Mark L. Chiu   +5 more
wiley   +1 more source

Dietary Patterns and Risk of Colorectal Cancer Subtypes Classified by Fusobacterium nucleatum in Tumor Tissue [PDF]

, 2018
Importance—Fusobacterium nucleatum appears to play a role in colorectal carcinogenesis through suppression of host immune response to tumor. Evidence also suggests that diet influences intestinal F. nucleatum. However, the role of F.
Bullman, Susan, Cao, Yin, Chan, Andrew T., Drew, David A., Fuchs, Charles S., Fung, Teresa T., Garrett, Wendy S., Giovannucci, Edward L., Hamada, Tsuyoshi, Huttenhower, Curtis, Kostic, Aleksandar D., Kosumi, Keisuke, Masugi, Yohei, Mehta, Raaj S., Meyerhardt, Jeffrey A., Mima, Kosuke, Nishihara, Reiko, Nowak, Jonathan A., Ogino, Shuji, Qian, Zhi Rong, Song, Mingyang, Willett, Walter C., Wu, Kana, Zhang, Xuehong   +23 more
core   +1 more source

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

FEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani, Tobias Dreyer, Meriem Naim, Rea Lo Dico, Natalia A. Ignatenko, Viktor Magdolen, Dalila Darmoul   +6 more
wiley   +1 more source

CRISPR Knockout of the HuR Gene Causes a Xenograft Lethal Phenotype. [PDF]

, 2017
Pancreatic ductal adenocarcinoma (PDA) is the third leading cause of cancer-related deaths in the United States, whereas colorectal cancer is the third most common cancer.
Brody, Jonathan, Campbell, Paul M., Chand, Saswati N., Cheung, Edwin C,, Dixon, Dan A., Goetz, Austin, Lal, Shruti, Londin, Eric, Lowder, Cinthya Y., Mambelli-Lisboa, Nicole C., Nevler, Avinoam, Preet, Ranjan, Romeo, Carmella, Stout, Matthew C., Winter, Jordan M., Yeo, Charles, Zarei, Mahsa   +16 more
core   +1 more source