Results 111 to 120 of about 5,919,627 (334)

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Colorectal Cancer Screening

Seminars in Roentgenology, 2015
Introduction Colorectal cancer (CRC) is well suited to screening. It is a common disease, affecting approximately 1 in 20 adults in the United States and Europe, ultimately proving fatal in almost 50%of cases. Symptoms are frequently nonspecific and are often common (eg, change in bowel habit and abdominal pain), leading many patients to ignore the ...
Plumb, AA, Halligan, S
openaire   +3 more sources

A preoperative MRI pelvic multiparameter nomogram for predicting sphincter preservation and operative difficulty in laparoscopic total mesorectal excision for ultra-low rectal cancer

BMC Surgery
Background Sphincter preservation (SP) during laparoscopic total mesorectal excision (LaTME) for low rectal cancer is challenged by a deep, narrow pelvis. Robust, MRI-based predictors for both SP success and operative difficulty are lacking.
Haipeng Jin, Qian Zhang, Longhai Feng, Rongbiao Ying, Haixing Ju   +4 more
doaj   +1 more source

Deep-Learning for Classification of Colorectal Polyps on Whole-Slide Images

, 2017
Histopathological characterization of colorectal polyps is an important principle for determining the risk of colorectal cancer and future rates of surveillance for patients. This characterization is time-intensive, requires years of specialized training,
Hassanpour, Saeed, Korbar, Bruno, Miraflor, Allen P., Nicka, Katherine M., Olofson, Andrea M., Suriawinata, Arief A., Suriawinata, Matthew A., Torresani, Lorenzo   +7 more
core   +2 more sources

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

Molecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa   +6 more
wiley   +1 more source

Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

Ca, 2018
This article provides a status report on the global burden of cancer worldwide using the GLOBOCAN 2018 estimates of cancer incidence and mortality produced by the International Agency for Research on Cancer, with a focus on geographic variability across ...
F. Bray, J. Ferlay, I. Soerjomataram, R. Siegel, Lindsey A. Torre, A. Jemal   +5 more
semanticscholar   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Identification of PANoptosis associated lncRNAs associated with clinical prognosis and immune infiltration microenvironment in colon adenocarcinoma

Discover Oncology
Early diagnosis and disease management based on risk stratification have a very positive impact on colon adenocarcinoma (COAD) prognosis. It is of positive significance to further explore risk stratification of COAD patients and identify predictive ...
Yangyang Wang, Shihui Zhao, Songtao Du, Tianyi Xia, Liqiang Song, Mingyu Xia, Bomiao Zhang   +6 more
doaj   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

Association between diverticulosis and colonic neoplastic lesions in individuals with a positive faecal immunochemical test [PDF]

, 2017
Background The association between diverticulosis and colonic neoplastic lesions has been suggested, but data in literature are conflicting. This study aimed to investigate such a relationship in patients participating in a colorectal cancer screening ...
Boggi, R., Hassan, C., Lorenzetti, R., Morini, S., Napoli, M., Ridola, L., Tomao, S., Zullo, A.   +7 more
core   +1 more source