Results 131 to 140 of about 648,498 (303)

Cross‐Scale Hierarchical Targeted Delivery System Based on Small‐Scale Magnetic Robots

Advanced Robotics Research, EarlyView.
This article reviews a cross‐scale hierarchical targeted delivery system that integrates magnetic continuum robots and magnetic microrobots. By combining rapid long‐range navigation with precise microscale targeting, the system overcomes key limitations of single‐scale approaches.
Junjian Zhou, Zhiqiang Chen, Yuanbiao Ma, Zhiqiang Tang, Qianqian Wang   +4 more
wiley   +1 more source

Pharmacogenomics and colorectal cancer

Annals of Oncology, 2004
The current methods of treating cancer patients with chemotherapeutics do not account for interpatient variability in the expression of particular target genes. This variability leads to unpredictable tumor responses and host toxicity. The approach we have taken is to determine gene expression levels in the metabolic pathways of drugs used in the ...
openaire   +3 more sources

Chromosomal Instability Drives Glioblastoma Heterogeneity and Therapeutic Opportunities

Advanced Science, EarlyView.
ABSTRACT Glioblastoma, the most aggressive and lethal form of brain cancer, is defined by profound genomic instability, with Chromosomal Instability (CIN) playing a central role in driving tumor progression, therapy resistance, and poor prognosis. CIN is characterized by numerical and structural alterations, is driven by mechanisms such as mitotic ...
Amarnath Pal, Milan Patra, Rianita Mondal, Shubhasis Haldar   +3 more
wiley   +1 more source

Prognostic Impact of Skip Metastasis to the Lateral Lymph Nodes in Lower Rectal Cancer

Journal of the Anus, Rectum and Colon
Objectives: Some patients with lower rectal cancer develop “skip metastasis,” in which lymph node metastasis occurs in the lateral but not the mesenteric lymph nodes. However, the prognostic impact of skip metastasis is unclear.
Sono Ito, Yasuyuki Takamizawa, Konosuke Moritani, Shunsuke Tsukamoto, Yukihide Kanemitsu   +4 more
doaj   +1 more source

LMO7 Suppresses Tumor‐Associated Macrophage Phagocytosis of Tumor Cells Through Degradation of LRP1

Advanced Science, EarlyView.
LMO7 in tumor‐associated macrophages suppresses phagocytosis of tumor cells and limits cytotoxic T lymphocytes infiltration, fostering tumor progression. Mechanistically, LMO7 mediates the ubiquitination and degradation of the phagocytic receptor LRP1, impairing its ability to engulf tumor cells and driving macrophages toward an antitumor phenotype ...
Mengkai Li, Tao Wang, Yuwen Zhong, Zhiming Wang, Wei Li, Zejian Wang, Xinyi Yang, Yu Qiao, Jianfeng Xiang, Wei Gu, Zishu Wang, Lei Sun, Feng Qian   +12 more
wiley   +1 more source

Gut Mycobiota‐Associated Tryptophan Catabolites Protect Against Metabolic Dysfunction‐Associated Steatotic Liver Disease

Advanced Science, EarlyView.
ABSTRACT Accumulating evidence suggests that the intestinal microbiota participates in the progression of metabolic dysfunction‐associated steatotic liver disease (MASLD) through microbiota‐host interaction. However, the beneficial role of commensal mycobiota in MASLD progression remains poorly understood.
Shuping Qiao, Shuangya Fan, Juan Xu, Zhen Xu, Chen Peng, Junxing Qu, Ziqian Bing, Shizhen Zhou, Sunan Shen, Guifang Xu, Yue Zhao, Tingting Wang   +11 more
wiley   +1 more source

Ataxia Telangiectasia Mutated Protein Loss and Benefit From Oxaliplatin-based Chemotherapy in Colorectal Cancer

, 2018
BACKGROUND: Loss of ataxia telangiectasia mutated (ATM), a key protein regulating DNA repair signaling, has been suggested to increase sensitivity to DNA damaging agents.
Bertan, C, Susana Miranda, Ines Figueiredo, Nina Tunariu, Mateo, J, Chénard-Poirier, M, Cunningham, D, Nicola Valeri, Andrew Wotherspoon, Carreira, S, Perez, DR, Claudia Bertan, de Bono, J, Wotherspoon, A, Rodrigues, DN, Wei Yuan, Gunther Boysen, Suzanne Carreira, Joaquin Mateo, Dolling, D, Yuan, W, Rossitza Chistova, Sundar, R, Ian Chau, Maxime Chénard-Poirier, Raghav Sundar, Ferreira, A, Johann de Bono, Daniel Nava Rodrigues, Miranda, S, Tunariu, N, David Dolling, Matthew Clarke, Figueiredo, I, Chistova, R, Ana Ferreira, Desamparados Roda Perez, Clarke, M, Chau, I, Boysen, G, David Cunningham, Valeri, N   +41 more
core   +1 more source

Targeting Lactate and Lactylation in Cancer Metabolism and Immunotherapy

Advanced Science, EarlyView.
Lactate, once deemed a metabolic waste, emerges as a central regulator of cancer progression. This review elucidates how lactate and its epigenetic derivative, protein lactylation, orchestrate tumor metabolism, immune suppression, and therapeutic resistance.
Jiajing Gong, Yuhang Xie, Zhijie Weng, Yongzhi Wu, Longjiang Li, Bo Li   +5 more
wiley   +1 more source

Screen for Life: National Colorectal Cancer Action Campaign 2012 year end report [PDF]

The Centers for Disease Control and Prevention\u2019s (CDC) Screen for Life: National Colorectal Cancer Action Campaign (SFL) is a multiyear, multimedia initiative to educate men and women aged 50 years and older\u2014the age group at greatest risk of ...

core   +2 more sources

Cancer colorectal : le rôle controversé de la consommation de viande [PDF]

, 1997
L’alimentation est considérée comme un facteur déterminant du développement du cancer colorectal. Les études internationales d’épidémiologie descriptive montrent une forte corrélation entre la mortalité due au cancer du côlon et la consommation de viande.
Parnaud, Géraldine, Corpet, Denis E.
core