Results 101 to 110 of about 5,919,627 (334)

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

MMP-2 and MMP-9 in normal mucosa are independently associated with outcome of colorectal cancer patients. [PDF]

, 2012
BackgroundUpregulation of the matrix metalloproteinases MMP-2 and MMP-9 in various cancers has been associated with worse survival of the patients.MethodsWe assessed MMP-2 and MMP-9 levels in normal colorectal mucosa from colorectal cancer patients in ...
Hardwick, JCH, Hawinkels, LJAC, Hommes, DW, Kubben, FJGM, Langers, AMJ, Sier, CFM, van der Reijden, JJ, van Duijn, W, Verspaget, HW   +8 more
core   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Multiple rapidly growing desmoid tumors that were difficult to distinguish from recurrence of rectal cancer

World Journal of Surgical Oncology, 2017
Background Intra-abdominal desmoid tumors are usually slow growing and solitary, but multifocal desmoid tumors develop on rare occasions. Diagnosing desmoid tumors before histological examination of a surgical biopsy is often difficult. In particular, if
Koki Nakanishi, Dai Shida, Shunsuke Tsukamoto, Hiroki Ochiai, Junichi Mazaki, Hirokazu Taniguchi, Yukihide Kanemitsu   +6 more
doaj   +1 more source

Staging the tumor and staging the host: A two centre, two country comparison of systemic inflammatory responses of patients undergoing resection of primary operable colorectal cancer [PDF]

, 2017
Background: How systemic inflammation-based prognostic scores such as the modified Glasgow Prognostic Score (mGPS) and neutrophil:lymphocyte ratio (NLR) differ across populations of patients with colorectal cancer (CRC) remains unknown.
Aoki, Taku, Horgan, Paul G., Ishizuka, Mitsuru, Iwasaki, Yoshimi, Kubota, Keiichi, McMillan, Donald C., McSorley, Stephen T., Nagata, Hitoshi, Park, James H., Roxburgh, Campbell S.D., Takagi, Kazutoshi   +10 more
core   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Effect of sex differences on the emergence of ctDNA RAS mutations in RAS wild-type colorectal cancer

Scientific Reports
In some cases of RAS wild-type metastatic colorectal cancer (mCRC), mutant RAS may emerge during chemotherapy. This study aimed to identify the clinicopathological factors associated with the emergence of RAS mutations during treatment.
Kenta Iguchi, Mamoru Uchiyama, Masahiro Asari, Koji Numata, Manabu Shiozawa   +4 more
doaj   +1 more source

Evaluation of the utility of a nomogram for predicting lymph node metastasis in T1 colorectal cancer in shared decision-making in clinical practice: a survey-based study [PDF]

Annals of Coloproctology
Purpose In 2019, we reported a novel nomogram to predict lymph node metastasis (LNM) in T1 colorectal cancer. Herein, we conducted a survey-based study to evaluate the clinical utility of this nomogram in determining the need for additional surgery after
Hyeon Seung Kim, Kyung Su Han, Min Wan Lee, Dae Kyung Sohn, Chang Won Hong, Dong Woon Lee, Kiho You, Sung Chan Park, Byung Chang Kim, Bun Kim, Jae Hwan Oh   +10 more
doaj   +1 more source

Nutritional and inflammatory measures predict survival of patients with stage IV colorectal cancer

BMC Cancer, 2020
Background This study aimed to evaluate the prognostic impact of nutritional and inflammatory measures (controlling nutritional status (CONUT) score, prognostic nutritional index (PNI), and modified Glasgow prognostic score (mGPS)) on overall survival ...
Yasuyuki Takamizawa, Dai Shida, Narikazu Boku, Yuya Nakamura, Yuka Ahiko, Takefumi Yoshida, Taro Tanabe, Atsuo Takashima, Yukihide Kanemitsu   +8 more
doaj   +1 more source

A cohort study of the recovery of health and wellbeing following colorectal cancer (CREW study): protocol paper [PDF]

, 2012
Background: the number of people surviving colorectal cancer has doubled in recent years. While much of the literature suggests that most people return to near pre-diagnosis status following surgery for colorectal cancer, this literature has largely ...
Addington-Hall, Julia M., Corner, Jessica L, Fenlon, Deborah R., Foster, Claire L., Richardson, Alison, Smith, Peter, Winter, Jane   +6 more
core   +2 more sources