Results 101 to 110 of about 3,531,408 (290)

Arginine methylation as a regulatory ratchet in cancer: From substrate selection to malignant‐state stabilization

Molecular Oncology, EarlyView.
Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley   +1 more source

Risk and Management of Bowel Obstruction in Colorectal Cancer Patients Undergoing Immunotherapy: A Cross-Sectional Multicenter Study

ImmunoTargets and Therapy
Zhi-Gang Hong,1,2,* Binyi Xiao,1,2,* Muxu Zheng,1,2,* Wanjun Yang,1,2,* Liangjun Zhu,3 Guodong Liang,4 Yuhao Luo,5 Jinghua Tang,1,2 Weijian Mei,1,2 Jie-Hai Yu,1,2 Zhenlin Hou,1,2 Xiaojun Wu,1,2 Peirong Ding,1,2 Wu Jiang1,2
Hong ZG, Xiao B, Zheng M, Yang W, Zhu L, Liang G, Luo Y, Tang J, Mei W, Yu JH, Hou Z, Wu X, Ding P, Jiang W   +13 more
doaj  

Neoadjuvant FOLFOXIRI chemotherapy with or without camrelizumab in the treatment of locally advanced rectal cancer: a retrospective cohort study

npj Precision Oncology
Standard neoadjuvant chemoradiotherapy for locally advanced rectal cancer (LARC) is associated with significant toxicity and limited pathological responses.
Yanlong Liu, Shihui Zhao, Fenqi Du, Songtao Du, Liqiang Song, Tianyi Xia, Bomiao Zhang, Binbin Cui   +7 more
doaj   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

PIK3CA in Colorectal Cancer [PDF]

Frontiers in Oncology, 2014
PIK3CA, the catalytic subunit of PI3K, is mutated in many different tumors, including colorectal cancer (CRC). Mutations of PIK3CA have been reported in 10-20% of CRC, about 80% of mutations found in two hot spots in exon 9 and exon 20. In RAS wild-type CRC, PIK3CA mutations have been associated with a worse clinical outcome and with a negative ...
openaire   +3 more sources

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

Gut microbiota alterations in patients with non‐small‐cell lung cancer undergoing chemoradiotherapy

Molecular Oncology, EarlyView.
We investigated the impact of concurrent chemoradiotherapy (CRT) on the gut microbiota in patients with locally advanced non‐small‐cell lung cancer. Overall gut microbiota composition remained largely stable throughout CRT while antibiotic exposure may influence microbial diversity.
Hanne Marte Nymoen, Zhi Zhao, Henrik Horndalsveen, Maria Moksnes Bjaanæs, Bjørn Henning Grønberg, Tarje Halvorsen, Tesfaye Madebo, Marianne Aanerud, Jussi Koivunen, Kersti Oselin, Saulius Cicenas, Nina Helbekkmo, Jarkko Ahvonen, Maria Silvoniemi, Tine Norman Alver, Tonje Dalen, Åsa Kristina Öjlert, Saima Jamil Farooqi, Åslaug Helland, Vilde Drageset Haakensen   +19 more
wiley   +1 more source

CNOT7 facilitates radiation resistance in colorectal cancer through TRIM21/XRCC6-mediated non-homologous end joining repair

Cell Death and Disease
Radiotherapy is essential in the treatment of colorectal cancer (CRC), but the presence of drug resistance leads to poor prognosis for CRC patients. Identifying targets and mechanisms for regulating radiotherapy resistance has high clinical value.
Yien Li, Luying Cui, Shaoke Wang, Qunye Zhao, Fenqi Du, Songtao Du, Chenfeng Yu, Mingyu Xia, Shihui Zhao, Tian Luan, Yanlong Liu, Binbin Cui   +11 more
doaj   +1 more source

Resection of the urinary bladder for locally advanced colorectal cancer: a retrospective comparison of partial versus total cystectomy

BMC Surgery, 2019
Background The postoperative and survival outcomes of patients with primary advanced colorectal cancer who undergo partial versus total cystectomy have not been adequately compared, as studies of this topic are rare and comprise relatively small cohorts.
Akihiro Kondo, Takeshi Sasaki, Daichi Kitaguchi, Yuichiro Tsukada, Yuji Nishizawa, Masaaki Ito   +5 more
doaj   +1 more source

Colorectal Cancer Screening

Seminars in Roentgenology, 2015
Introduction Colorectal cancer (CRC) is well suited to screening. It is a common disease, affecting approximately 1 in 20 adults in the United States and Europe, ultimately proving fatal in almost 50%of cases. Symptoms are frequently nonspecific and are often common (eg, change in bowel habit and abdominal pain), leading many patients to ignore the ...
Plumb, AA, Halligan, S
openaire   +3 more sources