Results 161 to 170 of about 5,474,833 (393)

Interplay of integrins and selectins in metastasis

Molecular Oncology, EarlyView.
Here we review the role of integrins and their interplay with selectins in metastasis. The efficacy of integrin‐targeted therapies may be reduced in tumors where metastasis relies heavily on selectins. In certain tumors, integrins and selectins exhibit a synergistic interaction during intraperitoneal dissemination.
Diana Maltseva, Ashot Nersisyan, Alexander Tonevitsky   +2 more
wiley   +1 more source

Ubiquitination of transcription factors in cancer: unveiling therapeutic potential

Molecular Oncology, EarlyView.
In cancer, dysregulated ubiquitination of transcription factors contributes to the uncontrolled growth and survival characteristics of tumors. Tumor suppressors are degraded by aberrant ubiquitination, or oncogenic transcription factors gain stability through ubiquitination, thereby promoting tumorigenesis.
Dongha Kim, Hye Jin Nam, Sung Hee Baek
wiley   +1 more source

Preoperative T staging using CT colonography with multiplanar reconstruction for very low rectal cancer

BMC Cancer, 2017
Background Preoperative T staging of lower rectal cancer is an important criterion for selecting intersphincteric resection (ISR) or abdominoperineal resection (APR) as well as selecting neoadjuvant therapy.
Dai Shida, Gen Iinuma, Akira Komono, Hiroki Ochiai, Shunsuke Tsukamoto, Mototaka Miyake, Yukihide Kanemitsu   +6 more
doaj   +1 more source

Development and external validation of a predictive scoring system associated with metastasis of T1‐2 colorectal tumors to lymph nodes

Clinical and Translational Medicine, 2020
Background It is critical for determining the optimum therapeutic solutions for T1‐2 colorectal cancer (CRC) to accurately predict lymph node metastasis (LNM) status.
Shaobo Mo, Zheng Zhou, Weixing Dai, Wenqiang Xiang, Lingyu Han, Long Zhang, Renjie Wang, Sanjun Cai, Qingguo Li, Guoxiang Cai   +9 more
doaj   +1 more source

Automatic Polyp Segmentation using U-Net-ResNet50 [PDF]

arXiv, 2020
Polyps are the predecessors to colorectal cancer which is considered as one of the leading causes of cancer-related deaths worldwide. Colonoscopy is the standard procedure for the identification, localization, and removal of colorectal polyps. Due to variability in shape, size, and surrounding tissue similarity, colorectal polyps are often missed by ...
arxiv  

Global colorectal cancer burden in 2020 and projections to 2040

Translational Oncology, 2021
Yue Xi, Pengfei Xu
semanticscholar   +1 more source

Analysis of Plasma Cell-Free DNA by Ultradeep Sequencing in Patients With Stages I to III Colorectal Cancer

JAMA Oncology, 2019
This cohort study investigates the use of longitudinal data from ultradeep sequencing of cell-free DNA in Danish patients with colorectal cancer.
T. Reinert, T. Henriksen, E. Christensen, Shruti Sharma, R. Salari, H. Sethi, Michael Knudsen, I. Nordentoft, Hsin-Ta Wu, Antony S. Tin, Mads Heilskov Rasmussen, Søren Vang, S. Shchegrova, Amanda Frydendahl Boll Johansen, R. Srinivasan, Z. Assaf, M. Balcioğlu, A. Olson, S. Dashner, D. Hafez, S. Navarro, Shruti Goel, M. Rabinowitz, P. Billings, S. Sigurjonsson, L. Dyrskjøt, R. Swenerton, A. Aleshin, S. Laurberg, A. Husted Madsen, A. Kannerup, K. Stribolt, Søren Palmelund Krag, L. Iversen, K. Gotschalck Sunesen, C. J. Lin, B. Zimmermann, C. Lindbjerg Andersen   +37 more
semanticscholar   +1 more source

Aberrant expression of nuclear prothymosin α contributes to epithelial‐mesenchymal transition in lung cancer

Molecular Oncology, EarlyView.
Nuclear prothymosin α inhibits epithelial‐mesenchymal transition (EMT) in lung cancer by increasing Smad7 acetylation and competing with Smad2 for binding to SNAI1, TWIST1, and ZEB1 promoters. In early‐stage cancer, ProT suppresses TGF‐β‐induced EMT, while its loss in the nucleus in late‐stage cancer leads to enhanced EMT and poor prognosis.
Liyun Chen, Chung‐Teng Wang, Jia‐Ming Chang, Ai‐Li Shiau, Gia‐Shing Shieh, Yau‐Lin Tseng, Yi‐Ting Yen, Tang‐Hsiu Huang, Li‐Hsin Cheng, Yu‐Chih Wu, Chao‐Liang Wu, Bing‐Hua Su, Pensee Wu   +12 more
wiley   +1 more source

Klotho negatively regulated aerobic glycolysis in colorectal cancer via ERK/HIF1α axis

Cell Communication and Signaling, 2018
Background Klotho (KL) was originally characterized as an aging suppressor gene, and has been identified as a tumor suppressor gene in a variety of cancers, including colorectal cancer.
Qingguo Li, Yaqi Li, Lei Liang, Jing Li, Dakui Luo, Qi Liu, Sanjun Cai, Xinxiang Li   +7 more
doaj   +1 more source

Targeted therapy for colorectal cancer metastases: A review of current methods of molecularly targeted therapy and the use of tumor biomarkers in the treatment of metastatic colorectal cancer

Cancer, 2019
Despite recent advances in the management of colorectal cancer, metastatic disease remains challenging, and patients are rarely cured. However, a better understanding of the pathways implicated in the evolution and proliferation of cancer cells has led ...
Sorbarikor Piawah, A. Venook
semanticscholar   +1 more source