Results 191 to 200 of about 5,289,946 (346)
Phase‐Separation of YAP Mediates AJUBA Super Enhancer Activation to Promote Aberrant Mitosis in Breast Cancer
Advanced Science, EarlyView.YAP undergoes phase separation to activate the AJUBA super‐enhancer, driving aberrant mitosis through spindle checkpoint dysregulation in breast cancer. This study uncovers a mechanistic link between YAP condensates, super‐enhancer activation, and aneuploidy formation.Rui Zhang, Qingwen Huang, Zhuo Chen, Weijian Meng, Hongliang Dong, Zhihong Qi, Liang Liu, Jie Shen, Daxing Xie +8 morewiley +1 more sourceCetuximab and chemotherapy as initial treatment for metastatic colorectal cancer.
New England Journal of Medicine, 2009 E. Van Cutsem, C. Köhne, E. Hitre, J. Zaluski, Chung-Rong Chang Chien, A. Makhson, G. D'Haens, T. Pintér, R. Lim, G. Bodoky, J. Roh, G. Folprecht, P. Ruff, C. Stroh, S. Tejpar, M. Schlichting, J. Nippgen, P. Rougier +17 moresemanticscholar +1 more sourceMutational signature in colorectal cancer caused by genotoxic pks+E. coli
Nature, 2020 Cayetano Pleguezuelos-Manzano, Jens Puschhof, Axel K M Rosendahl Huber, Arne van Hoeck, H. Wood, Jason Nomburg, C. Gurjao, F. Manders, G. Dalmasso, P. Stege, F. Paganelli, Maarten H. Geurts, J. Beumer, Tomohiro Mizutani, Y. Miao, Reinier van der Linden, S. van der Elst, J. C. P. E. L. M. F. J. M. C. R. H. M. J. G. C. C. E. Ambrose Arumugam Baple Bleda Boardman-Pretty Boiss, J. Ambrose, P. Arumugam, E. Baple, M. Bleda, F. Boardman-Pretty, J. Boissiere, C. Boustred, H. Brittain, M. Caulfield, G. Chan, C. Craig, L. Daugherty, A. de Burca, A. Devereau, G. Elgar, R. E. Foulger, T. Fowler, P. Furió-Tarí, J. Hackett, D. Halai, A. Hamblin, S. Henderson, J. Holman, T. Hubbard, K. Ibáñez, R. Jackson, L. J. Jones, D. Kasperaviciute, M. Kayikci, L. Lahnstein, L. Lawson, S. Leigh, I. Leong, F. J. Lopez, F. Maleady-Crowe, J. Mason, E. McDonagh, L. Moutsianas, M. Mueller, N. Murugaesu, A. Need, C. Odhams, C. Patch, D. Perez-Gil, D. Polychronopoulos, J. Pullinger, T. Rahim, A. Rendon, P. Riesgo-Ferreiro, T. Rogers, M. Ryten, K. Savage, K. Sawant, R. Scott, A. Siddiq, A. Sieghart, D. Smedley, K. Smith, A. Sosinsky, W. Spooner, H. E. Stevens, A. Stuckey, R. Sultana, E. Thomas, S. Thompson, C. Tregidgo, A. Tucci, E. Walsh, S. Watters, M. Welland, E. Williams, K. Witkowska, S. Wood, M. Zarowiecki, K. Garcia, J. Top, R. Willems, M. Giannakis, R. Bonnet, P. Quirke, M. Meyerson, E. Cuppen, R. van Boxtel, H. Clevers +101 moresemanticscholar +1 more sourcePEPCOL: a GERCOR randomized phase II study of nanoliposomal irinotecan PEP02 (MM‐398) or irinotecan with leucovorin/5‐fluorouracil as second‐line therapy in metastatic colorectal cancer [PDF]
, 2016 Benoist Chibaudel, Frédérique Maindrault‐Gœbel, Jean‐Baptiste Bachet, Christophe Louvet, Ahmed Khalil, Olivier Dupuis, Pascal Hammel, Marie‐Line Garcia, Mostefa Bennamoun, David Brusquant, Christophe Tournigand, Thierry André, Claire Arbaud, Annette K. Larsen, Yiwen Wang, C. Grace Yeh, Franck Bonnetain, Aimery de Gramont +17 moreopenalex +1 more sourcePre‐Administration of Akkermansia Muciniphila Prevents the Development of Severe Acute Graft‐Versus‐Host Disease in Systemic Organs
Advanced Science, EarlyView.Akkermansia muciniphila, a next‐generation probiotic, alleviates acute graft‐versus‐host disease (aGvHD) following allogeneic hematopoietic stem cell transplantation (HSCT) by providing protective effects across multiple organs. Pre‐colonization with A.Jeong‐Eun Han, Dae‐Seong Lee, Su‐Won Jeong, Ji‐Hyun Yun, Seomin Kang, Seoyoung Jang, EunAh Lee, Ju Hye Baek, Che Ok Jeon, Jin‐Woo Bae +9 morewiley +1 more sourceThe genomic and transcriptomic landscapes of clock genes reveal the significance of circadian rhythm in the progression and immune microenvironment of metastatic colorectal cancer
Clinical and Translational Medicine, 2022 Long Zhang, Yikuan Chen, Choon Seng Chong, Xiaoji Ma, Shanyou Tong, Xingfeng He, Yiwei Li, Sanjun Cai, Shaobo Mo, Junjie Peng, Xiang Hu +10 moredoaj +1 more sourceA novel β-carboline alkaloid derivative targeting MDM2-p53 pathway suppresses colorectal cancer progression [PDF]
Fanbin Zeng, Cheng Chen, Zhanwei Fu, Haihui Huang, Wenqiang Cui, Yuanyuan Zhou, Yanjie Kong, Xia Liu, Zhiru Xu, Shouguo Wang, Tian Xiao, Houjun Xia +11 moreopenalex +1 more source
