Results 191 to 200 of about 5,919,627 (334)

Germline Predisposition to Oncogenic Alkylating Damage in Colorectal Cancer. [PDF]

Cancer Epidemiol Biomarkers Prev
Gurjao C, Cazaubiel J, Tan C, Reardon B, Hofree M, Ugai T, Meyerhardt JA, Nowak JA, Giovannucci E, Townsend JP, Ogino S, Giannakis M.   +11 more
europepmc   +1 more source

Highly Active Cu14 Cluster Precisely Activates Autophagy Inhibitor to Amplify Cuproptosis Immunotherapy

Advanced Science, EarlyView.
An atomically precise Cu14 cluster‐mediated bond scission reaction pioneers the amplification of the antitumor immune response via synergetic cuproptosis‐associated immunogenic cell death induction and in situ autophagy blockade. ABSTRACT Transition metal‐mediated cleavage mechanisms have emerged as an effective means to mitigate the off‐target ...
Qiu‐Xu Zang, Wei‐Tong Chen, Yu‐Ying Shen, Zhao‐Yang Wang, Kai Li, Xueli Zhao, Yanjuan Sang, Xiaoyuan Chen, Shuang‐Quan Zang   +8 more
wiley   +1 more source

Ginsenoside Rg5 inhibits colorectal cancer, at least partially by blocking the lysosomal degradation of colorectal cancer cells. [PDF]

Sci Rep
Guo X, Sun R, Su Y, Qin Q, Liu Y, Qiu C.
europepmc   +1 more source

Immunotherapy in colorectal cancer: rationale, challenges and potential

Nature reviews: Gastroenterology & hepatology, 2019
K. Ganesh, Z. Stadler, A. Cercek, R. Mendelsohn, J. Shia, N. Segal, L. Diaz   +6 more
semanticscholar   +1 more source

GPCRs in CAR‐T Cell Immunotherapy: Expanding the Target Landscape and Enhancing Therapeutic Efficacy

Advanced Science, EarlyView.
Chimeric antigen receptor T cell therapy faces dual challenges of target scarcity and an immunosuppressive microenvironment in solid tumors. This review highlights how G protein‐coupled receptors can serve as both novel targets to expand the therapeutic scope and functional modules to enhance CAR‐T cell efficacy.
Zhuoqun Liu, Yuchen Xiao, Yamin Zhao, Lihe Dai, David J.H. Shih, Shikang Liang, Honglei Tian, Liu Liu, Feng Tian, Bing Liu, Lei Chang, Chao Zhang   +11 more
wiley   +1 more source

The quadruple immunotherapy for colorectal cancer (QuICC) trial for mismatch repair-proficient metastatic colorectal cancer. [PDF]

Oncologist
Bracken-Clarke D, Pastor DM, Marté JL, Donahue RN, Hodge JW, Cordes L, Floudas CS, Tschernia NP, Karzai F, Brownell I, Turkbey EB, Soon-Shiong P, Schlom J, Gulley JL, Maeng HM, Strauss J, Redman JM.   +16 more
europepmc   +1 more source

Gemella morbillorum Promotes Colorectal Carcinogenesis: LPBDCP‐Mediated Invasion Activates Ras Signaling and Destabilizes p53

Advanced Science, EarlyView.
ABSTRACT Gut microbiota dysbiosis promotes colorectal cancer (CRC) tumorigenesis. A global fecal metagenomic analysis identified Gemella morbillorum as a key contributor to the CRC‐associated microbiota. Fluorescence in situ hybridization revealed that Gemella morbillorum is enriched in CRC tumor tissues compared to adjacent normal tissues.
Zhen Wang, Jia Zhang, Haojie Lu, Jingjing Ni, Shuaishuai Yang, Yuting Shi, Shuo Zhang, Pei Zhang, Li Liu   +8 more
wiley   +1 more source

Analysis of Autophagy-Related Gene Signature Associated With Clinical Prognosis and Immune Microenvironment in Colorectal Cancer

Mediators of Inflammation
Dazhuang Miao, Yushui Song, Liang Zhou, Guanying Liang, Yan Wang, Wei He, Luyu Huang, Hongnan Lu, Shixiong Jiang, Yunhe Jia, Zhiwei Li, Jinxue Tong   +11 more
doaj   +1 more source

Clinical score for predicting recurrence after hepatic resection for metastatic colorectal cancer: analysis of 1001 consecutive cases.

Annals of Surgery, 1999
Y. Fong, J. Fortner, Ruth L. Sun, M. Brennan, L. Blumgart   +4 more
semanticscholar   +1 more source

Multicohort Validation of Gut Microbiome Signatures for Cholangiocarcinoma Diagnosis and Functional Characterization of Bifidobacterium Pseudocatenulatum

Advanced Science, EarlyView.
This study analyzes gut bacteria in cholangiocarcinoma patients, revealing distinct microbial signatures that enable accurate disease detection. Species‐based diagnostic models achieved over 98% accuracy in identifying cholangiocarcinoma and distinguished it from other liver diseases. The research demonstrates that specific beneficial bacteria suppress
Benchen Rao, Jianwen Jiang, Ruiqing Zhang, Dongya Zhang, Chenchen Zhang, Ang Li, Haifeng Lu, Hua Zhang, Lin Zhou, Wenzhi Guo, Peihao Wen, Jianfeng Xue, Jie Pan, Tuerganaili Aji, Zhou Lan, Xianzhi Jiang, Shusen Zheng, Zujiang Yu, Zhigang Ren   +18 more
wiley   +1 more source