Results 231 to 240 of about 3,531,408 (290)

Low SLC8A1 in Colorectal Cancer Dictates Radiotherapy Resistance Through Calcium‐Dependent ANXA2+sEVs Driving M2 Polarization of TAMs

Advanced Science, EarlyView.
SLC8A1 deficiency in colorectal cancer cells increases intracellular calcium signaling, promoting the secretion of ANXA2‐enriched small extracellular vesicles. These vesicles reprogram tumor‐associated macrophages towards an M2 phenotype, which in turn fosters a tumor microenvironment conducive to radioresistance and is associated with poor patient ...
Yimin Fang, Jinghan Zhu, Qian Xiao, Qichun Wei, Xiujing He, Ping Li, Kai Jiang, Yue Liu, Yeting Hu, Weiwei Yu, Chuansheng Guo, Sheng Chen, Jian Zhao, Siqi Dai, Jingsun Wei, Hang Yang, Tongtong Bu, Kefeng Ding, Haiyan Chen   +18 more
wiley   +1 more source

Colorectal Cancer Risk Factors in Adults in Nigeria.

JAMA Netw Open
Alatise OI, Peeri NC, Abdulkareem FB, Badejo OA, Gali BM, Oludara M, Okereke CE, Olatoke SA, Ademakinwa OR, Alabi A, Aderounmu A, Adeomi A, Mohammed T, Adegboyega O, Adisa A, Ajewole O, Famurewa OC, Agodirin SO, Ariyibi O, Nggada HA, Babatunde OJ, Badmos K, Balogun OS, Bamidele CO, Batta CS, Betiku OA, Bojuwoye MO, Choonawala NR, Cookey C, Daji FY, Egberongbe A, Esan O, Folaranmi OO, Fasiku OK, Fatusi A, Fodero R, Francis AO, Gallagher G, Habeeb MYM, Shittu HA, Iasonos A, Ige OE, Ikujenlola AV, Igetei R, Jackman JM, Kahn R, Katung A, Koiki MA, Komolafe AO, Lawrence AP, Lawal A, Lawal NOO, Makanjuola A, Mobolaji J, Omodele F, Na'aya HU, Nganjiwa US, Njokanma I, Nuhu A, Nwachukwu E, O'Connell K, Odunafolabi T, Ogunleye SO, Olaofe OO, Olcese C, Ologunagba PO, Olokoba A, Olasehinde O, Olajide TO, Osinowo AO, Omoyiola OZ, Omisore AD, Onyekwere C, Owoade IA, Oyesegun R, Samson ML, Sanni A, Sharma A, Sowunmi A, Sulaiman AT, Adebukola OT, Wuraola F, Adeleye AO, Adewunmi OL, Zarami AB, Kingham TP, Du M.   +86 more
europepmc   +1 more source

Autophagy Orchestrates Anti‐Tumor Immunity to Enhance Chemosensitivity via the FBXW2/C/EBPβ/TIMP‐2 Axis in Colorectal Cancer

Advanced Science, EarlyView.
Chemotherapy leverages tumor‐cell autophagy to reshape the colorectal cancer immune microenvironment. Autophagy degrades FBXW2 to promote C/EBPβ‐mediated TIMP‐2 transcription and MMP‐9 suppression, driving intra‐tumoral CD8+ T‐cell infiltration. Targeting MMP‐2/9 or restoring TIMP‐2 overcomes chemo‐resistance in autophagy‐deficient tumors. ABSTRACT The
Bing Cheng, Chaoying Wei, Zhitong Niu, Jinxin Chen, Guojie Long, Yingzhen Weng, Qiufeng Liu, Yue Jiang, Panpan Wang, Ronghua Zhang, Qiang Yu, Xiaojian Wu, Wenyu Wang   +12 more
wiley   +1 more source

Extending the utility of anti-EGFR therapy in metastatic colorectal cancer. [PDF]

J Gastrointest Oncol
Cann C, Vijayvergia N.
europepmc   +1 more source

Tissue‐Agnostic Cellular Morphometric Biomarkers for Risk‐Adapted Management Across Gastrointestinal Precancerous Lesions and Cancers

Advanced Science, EarlyView.
An interpretable, unsupervised artificial intelligence framework identifies a 13‐cellular morphometric biomarker (CMB) signature from routine H&E whole‐slide images. Validated across 2,602 patients, the fixed signature generalizes across colorectal, gastric, and esophageal tissues without retraining, stratifies prognosis and precancerous lesion risk ...
Pin Wang, Chengfei Jiang, April W. Mao, Qi Sun, Yijun Lu, Jingjing Wei, Jamie L. Inman, Susan E. Celniker, Antoine M. Snijders, David W. Threadgill, Allan Balmain, Bo Hang, Hang Chang, Lei Wang, Jian‐Hua Mao   +14 more
wiley   +1 more source

Socioeconomic disparities in survival of patients with superficial colorectal cancer. [PDF]

Discov Oncol
Chen S, Zhao S, Li J, Du S.
europepmc   +1 more source

Phase Separation, Material State, and Condensate Fate in Mammalian Autophagy

Advanced Science, EarlyView.
ABSTRACT Biomolecular phase separation has emerged as a key organizing principle in macroautophagy (hereafter autophagy). In mammalian cells, phase‐separated condensates not only serve as substrates for selective degradation, but also act as dynamic platforms for cargo recognition, signaling integration, and autophagosome assembly.
Yuanqiang Lin, Mingran Dai, Enyong Dai, Rui Kang, Daniel J. Klionsky, Daolin Tang, Yu Sun, Ningning Lv, Junnan Jiang   +8 more
wiley   +1 more source

Epigenetic Silencing of miR-124 Drives KITENIN Activation in Colorectal Cancer. [PDF]

Biomol Ther (Seoul)
Park SY, Varlı M, Kim H.
europepmc   +1 more source

Acromegaly and colorectal cancer risk: emerging roles of the gut microbiota. [PDF]

Front Endocrinol (Lausanne)
Grifoni GFA, Favero V, Cozzi RC, Chiodini I.   +3 more
europepmc   +1 more source

Corynoxine Inhibits Tumor Growth via Targeting NQO1 and Modulating the PTPA–NQO1/PP2A Switch to Activate PP2A

Advanced Science, EarlyView.
Corynoxine exerts potent broad‐spectrum anticancer activity by directly targeting NQO1. This interaction dissociates the oncogenic NQO1‐PTPA complex, releasing PTPA to robustly activate the tumor suppressor PP2A. Consequently, downstream Raf/MEK/ERK and PI3K/AKT signaling pathways are suppressed, downregulating c‐Myc and driving tumor regression ...
Guoqing Hou, Li Lin, Mengjie Xia, Ruohan Liang, Yueyue Zhang, Linna Du, Xuan Cao   +6 more
wiley   +1 more source