Results 241 to 250 of about 648,498 (303)

Compact Tabletop Magnetic Resonance Elastography for Mapping Soft Tissue Viscoelasticity

Advanced Science, EarlyView.
This work introduces a compact, low‐cost tabletop magnetic resonance elastography platform for high‐resolution viscoelastic mapping in soft‐tissue specimens. Using this method in human colorectal liver metastases, we demonstrate fully automated biomechanical profiling of treatment response and show that heterogeneity‐based metrics outperform ...
Weijie Zhao, Lisa‐Marie Skrip, Heiko Tzschätzsch, Tom Meyer, Hossein S. Aghamiry, Alexander Arnold, Lene Änne Böhne, Jakob Jordan, Oliver Boehm, Agnes K. Boehm, Steffen Görner, Jakob Schattenfroh, Yanglei Wu, Pedro Augusto Dantas de Moraes, Johann Pratschke, Jürgen Braun, Igor M. Sauer, Jing Guo, Ingolf Sack, Karl H. Hillebrandt   +19 more
wiley   +1 more source

PRDM Proteins Orchestrate Colorectal Cancer Tumorigenesis. [PDF]

Int J Mol Sci
Di Zazzo E, Sorrentino C, Rienzo M, Fiore D, Proto MC, Casamassimi A, Gazzerro P, Abbondanza C.   +7 more
europepmc   +1 more source

Targeting PLD3 Reverses the Immunosuppressive Niche by Reprogramming Tumor‐Associated Macrophages and Potentiates Antitumor Immunity

Advanced Science, EarlyView.
PLD3 activates the lysosomal‐AKT‐NF‐κB axis to drive cellular senescence in macrophages, establishing an immunosuppressive TME by limiting the infiltration of cytotoxic T, NK, and NKT cells, which confers resistance to anti‐PD‐1 therapy. Abrine inhibits PLD3 expression, restoring antitumor immunity and synergizing with anti‐PD‐1 treatment.
Xingtu Qin, Qiong Li, Xuemei Xu, Yuhan Wu, Yin Zhu, Jieqiong Wu, Yuan Fang, Qiubei Chen, Shuyang Wang, Jiang Yu, Yaping Ye, Hongli Jiao   +11 more
wiley   +1 more source

Perforin and Granulysin-Mediated Cytotoxicity in Colorectal Cancer Patients. [PDF]

Medicina (Kaunas)
Letica L, Lubina IŠ, Brekalo Z, Bačić Đ, Roganović J, Đorđević A, Udović IŠ, Letica I, Kotri I, Mrakovčić-Šutić I.   +9 more
europepmc   +1 more source

ABHD17C‐Mediated S‐Depalmitoylation of BCL6B Enhances CD24 Transcription to Resist Macrophage Phagocytosis in Pancreatic Cancer

Advanced Science, EarlyView.
ABHD17C‐mediated depalmitoylation of BCL6B at Cys442 blocks its nuclear import and triggers ubiquitin‐dependent degradation, attenuating transcriptional repression of the anti‐phagocytic signal CD24. This mechanism enables pancreatic cancer cells to evade macrophage phagocytosis and fosters an immunosuppressive microenvironment.
Yalu Zhang, Di Cui, Fanzheng Meng, Xu Zhu, Liang Zhu, Liang Wu, Haifeng Hu, Jizhou Wang, Hanhui Yao, Lianxin Liu   +9 more
wiley   +1 more source

Sequential invitations to FOBT screening and colorectal cancer incidence. [PDF]

Sci Rep
Wang X, Ribbing Wilén H, Phillips RV, Wang Z, van der Laan MJ, Yin L, Blom J.   +6 more
europepmc   +1 more source

Aptamer‐Targeted PrPC Drives Colorectal Cancer Metastasis via a LYN‐STAT3 Complex and Enables Liquid Biopsy Detection

Advanced Science, EarlyView.
The aptamer WHY‐3E identifies PrPC as a CRC driver. Stabilized by USP18, endocytosed PrPC forms a LYN/STAT3 complex, upregulating MSN transcription to promote metastasis. Crucially, WHY‐3E sensitively detects PrPC‐positive circulating exosomes, establishing a robust theoretical foundation for non‐invasive clinical diagnostics.
Chunlin Wang, Hongyu Wu, Chaojing Zheng, Hao Zhang, Xiaoqiu Wu, Jiaqi Wang, Zewen Chang, Jun Xiang, Yunxiao Liu, Chenkai Zhang, Yuliuming Wang, Hao Jiang, Yuchen Zhong, Jun Luo, Ying Chen, NaNa Zhang, Weiyuan Zhang, Ziming Yuan, ChaoXia Zou, Weihong Tan, Meng Wang, Hanqing Hu, Tao Bing, Guiyu Wang   +23 more
wiley   +1 more source

Development and Validation of a Predictive Nomogram for Diagnosing Colorectal Cancer Based on Immune-Nutritional Score. [PDF]

Cancer Med
Liu X, Shan L, Liang W, Fu L, Wu R, Zhang L, Lv Q, Shi W, Fei F.   +8 more
europepmc   +1 more source

SSR4 sustains Tertiary Lymphoid Structures by Regulation Quality Control of N‐linked Glycosylation During B‐cell Differentiation Into Plasmacyte in Colorectal Cancer

Advanced Science, EarlyView.
SSR4, a TRAP component induced in B cells, governs BAFFR N‐glycosylation via DDOST to sustain NF‐κB signaling, B‐cell differentiation, and TLS maturation. Its loss impairs anti‐tumor immunity, while overexpression improves antibody glycosylation and ADCC, revealing a critical regulator for cancer immunotherapy.
Wei Zhao, Youcai Zhao, Haiyang Li, Bowen Yang, Siyan Lu, Xueting Fu, Caixia Zhang, Yirong Chen, Xiaofeng Bian, Xinghua Ma, Xiaobing Yang, Bin Wang, Yuan Fang, Lulu Yang, Yelin Zhao, Shuli Zhao   +15 more
wiley   +1 more source

Probiotics in colorectal cancer: mechanisms, biomarkers, and adjunct strategies. [PDF]

Cancer Biol Med
Xu Z, Mu L, Su H, Zhang X, Shang H, Li Z, Tak Vai Chan M, Ka Kei Wu W, Chen H.   +8 more
europepmc   +1 more source