Results 271 to 280 of about 5,919,627 (334)

Analysis of the correlation between combined multiple cytokine detection and colorectal cancer. [PDF]

Sci Rep
Hui Y, Chu M, Wang H, Ren L, Wu J, Niu X, Zhang L, Su W.   +7 more
europepmc   +1 more source

POU2F1 Promotes Chemoresistance in Colorectal Cancer Cells via Attenuates the MDR2 Degradation Mediated by PPP1R11 Lactylation

Advanced Science, EarlyView.
Schematic diagram of our study showing that highly expressed POU2F1 in colorectal cancer (CRC) can directly accelerate the cytosolic lactate export to decrease PPP1R11 lactylation at K59, thereby attenuating the E3 ligase enzyme activity and protein stability of PPP1R11, which inhibits the ubiquitination of MDR2 at K413 and K538 but increases the ...
Longzheng Xia, Jinguan Lin, Xianjie Jiang, Linda Oyang, Shiming Tan, Zongyao Ren, Qiu Peng, Qianjin Liao, Yujuan Zhou   +8 more
wiley   +1 more source

Functional role of small extrachromosomal circular DNA in colorectal cancer. [PDF]

Proc Natl Acad Sci U S A
Hariprakash JM, Zole E, Feng W, Hao D, Bøllehuus Hansen L, Bandyopadhyay N, Mohiyuddin M, Wu S, Zedlitz Johansen A, Sidenius Johansen J, Regenberg B.   +10 more
europepmc   +1 more source

EEPD1 Inhibition Unleashes Antitumor Immunity in Colorectal Cancer by Activating the cGAS‐STING Pathway

Advanced Science, EarlyView.
In colorectal cancer, high expression of the DNA repair protein EEPD1 correlates with immune exclusion and poor prognosis. This study demonstrates that EEPD1 depletion induces genomic instability, leading to cytosolic DNA accumulation and subsequent activation of the cGAS‐STING‐type I interferon pathway. This cascade remodels the tumor microenvironment
Liyun Huo, Chong Wu, Xiaobo Li, Caina Ma, Jiamin Huang, Zishuo Chen, Weiling He, Tianyu Tao, Weijing Zhang   +8 more
wiley   +1 more source

SERPINA4 facilitates colorectal cancer progression through m⁶A-dependent stabilization. [PDF]

J Transl Med
Zhang X, Liu Y, Tu Q, Zhang D, Deng J, Zhou J, Lv H, Zhou J, Qiu F, Deng Y.   +9 more
europepmc   +1 more source

Detachment‐Induced FAK‐STAT3‐NNMT Inhibits CTCs Anoikis to Promote Breast Cancer Metastasis by Enhancing Fatty Acid Oxidation

Advanced Science, EarlyView.
The FAK‐STAT3‐NNMT axis drives anoikis resistance in circulating tumor cells by reprogramming fatty acid oxidation. Targeting this metabolic vulnerability suppresses metastasis, untangling a key mechanism of breast cancer progression and revealing NNMT as a promising therapeutic target.
Qingchao Tong, Yilei Ma, Yuzhen Gao, Lin Zhou, Luping Lou, Qiang Fang, Sining Fang, Ru Zhao, Jin Zeng, Jun Yang, Guoli Li, Xinyou Xie, Yanzhong Wang, Jun Zhang   +13 more
wiley   +1 more source

Epigenetic Alterations in Colitis-Associated Colorectal Cancer. [PDF]

Epigenomes
Ganesh N, Grady WM, Kaz AM.
europepmc   +1 more source

SENP3 drives colorectal cancer progression by enhancing GDF15 expression. [PDF]

Int J Colorectal Dis
Yu Y, Bao W, Chen J, Li Y, Gao Y.
europepmc   +1 more source

Sigmoid diverticulitis mimicking colorectal cancer: A case report. [PDF]

Radiol Case Rep
Nkenguye W, Amsi P, Lodhia J.
europepmc   +1 more source