Results 81 to 90 of about 5,582,484 (376)

Clinical Outcomes of Reduced-Port Laparoscopic Surgery for Patients With Sigmoid Colon Cancer: Surgery With 1 Surgeon and 1 Camera Operator [PDF]

Annals of Coloproctology, 2018
Purpose This study compared the perioperative clinical outcomes of reduced-port laparoscopic surgery (RPLS) with those of conventional multiport laparoscopic surgery (MPLS) for patients with sigmoid colon cancer and investigated the safety and ...
Jung Ryul Oh, Sung Chan Park, Sung Sil Park, Beonghoon Sohn, Hyoung Min Oh, Bun Kim, Min Jung Kim, Chang Won Hong, Kyung Su Han, Dae Kyung Sohn, Jae Hwan Oh   +10 more
doaj   +1 more source

Prognostic Value of Computed Tomography : Measured Parameters of Body Composition in Primary Operable Gastrointestinal Cancers [PDF]

, 2017
Professor Graeme Murray, Department of Pathology, University of Aberdeen provided us access to the colorectal cancer pathology databases from which the colorectal component of the research was based.
Black, Douglas, Hamoodi, Zaid, Loudon, Malcolm, MacKay, Craig, Nanthakumaran, Shayanthan, Park, Kenneth G. M., Ramsay, George, Richards, Colin H.   +7 more
core   +2 more sources

Japanese Society for Cancer of the Colon and Rectum (JSCCR) guidelines 2019 for the treatment of colorectal cancer

International Journal of Clinical Oncology, 2019
The number of deaths from colorectal cancer in Japan continues to increase. Colorectal cancer deaths exceeded 50,000 in 2016. In the 2019 edition, revision of all aspects of treatments was performed, with corrections and additions made based on knowledge
Y. Hashiguchi, K. Muro, Yutaka Saito, Yoshinori Ito, Y. Ajioka, T. Hamaguchi, K. Hasegawa, K. Hotta, H. Ishida, M. Ishiguro, S. Ishihara, Y. Kanemitsu, Y. Kinugasa, K. Murofushi, T. Nakajima, S. Oka, Toshiaki Tanaka, H. Taniguchi, A. Tsuji, K. Uehara, H. Ueno, T. Yamanaka, K. Yamazaki, Masahiro Yoshida, T. Yoshino, M. Itabashi, K. Sakamaki, K. Sano, Y. Shimada, Shinji Tanaka, H. Uetake, S. Yamaguchi, Naohiko Yamaguchi, H. Kobayashi, K. Matsuda, K. Kotake, K. Sugihara   +36 more
semanticscholar   +1 more source

Fusobacterium Nucleatum Promotes the Development of Colorectal Cancer by Activating a Cytochrome P450/Epoxyoctadecenoic Acid Axis via TLR4/Keap1/NRF2 Signaling

Cancer Research, 2021
This study uncovers a mechanism by which Fusobacterium nucleatum regulates colorectal cancer metabolism to drive metastasis, suggesting the potential biomarker and therapeutic utility of the CYP2J2/12,13-EpOME axis in Fn-infected patients.
C. Kong, Xuebing Yan, Yefei Zhu, Huiyuan Zhu, Ying Luo, Peipei Liu, S. Ferrandon, M. Kalady, R. Gao, Jide He, Fang Yin, Xiao Qu, Jiayi Zheng, Yaohui Gao, Q. Wei, Yanlei Ma, Jun-Yan Liu, H. Qin   +17 more
semanticscholar   +1 more source

Targeting the AKT/mTOR pathway attenuates the metastatic potential of colorectal carcinoma circulating tumor cells in a murine xenotransplantation model

Molecular Oncology, EarlyView.
Dual targeting of AKT and mTOR using MK2206 and RAD001 reduces tumor burden in an intracardiac colon cancer circulating tumor cell xenotransplantation model. Analysis of AKT isoform‐specific knockdowns in CTC‐MCC‐41 reveals differentially regulated proteins and phospho‐proteins by liquid chromatography coupled mass spectrometry. Circulating tumor cells
Daniel J. Smit, Thais Pereira‐Veiga, Helena Brauer, Michael Horn, Paula Nissen, Thomas Mair, Bente Siebels, Hannah Voß, Ruimeng Zhuang, Marie‐Therese Haider, Desiree Loreth, Margarita Iskhakova, Bele Lindemann, Julian Kött, Laure Cayrefourcq, Jasmin Wellbrock, Hartmut Schlüter, Klaus Pantel, Catherine Alix‐Panabières, Manfred Jücker   +19 more
wiley   +1 more source

Creation of a Novel Nomogram Based on the Direct Bilirubin-To-Indirect Bilirubin Ratio and Lactate Dehydrogenase Levels in Resectable Colorectal Cancer

Frontiers in Molecular Biosciences, 2021
Background: Recently, many studies have suggested that bilirubin is associated with the prognosis of colorectal cancer (CRC). Conversely, there is substantial evidence that lactate dehydrogenase (LDH) levels are associated with the prognosis of cancer ...
Yifei Ma, Yifei Ma, Yifei Ma, Lulu Shi, Lulu Shi, Ping Lu, Ping Lu, Ping Lu, Shuang Yao, Shuang Yao, Hongli Xu, Hongli Xu, Hongli Xu, Junjie Hu, Junjie Hu, Junjie Hu, Xin Liang, Xin Liang, Xin Liang, Xinjun Liang, Xinjun Liang, Xinjun Liang, Shaozhong Wei, Shaozhong Wei, Shaozhong Wei   +24 more
doaj   +1 more source

Aberrant expression of nuclear prothymosin α contributes to epithelial‐mesenchymal transition in lung cancer

Molecular Oncology, EarlyView.
Nuclear prothymosin α inhibits epithelial‐mesenchymal transition (EMT) in lung cancer by increasing Smad7 acetylation and competing with Smad2 for binding to SNAI1, TWIST1, and ZEB1 promoters. In early‐stage cancer, ProT suppresses TGF‐β‐induced EMT, while its loss in the nucleus in late‐stage cancer leads to enhanced EMT and poor prognosis.
Liyun Chen, Chung‐Teng Wang, Jia‐Ming Chang, Ai‐Li Shiau, Gia‐Shing Shieh, Yau‐Lin Tseng, Yi‐Ting Yen, Tang‐Hsiu Huang, Li‐Hsin Cheng, Yu‐Chih Wu, Chao‐Liang Wu, Bing‐Hua Su, Pensee Wu   +12 more
wiley   +1 more source

Detecting homologous recombination deficiency for breast cancer through integrative analysis of genomic data

Molecular Oncology, EarlyView.
This study develops a semi‐supervised classifier integrating multi‐genomic data (1404 training/5893 validation samples) to improve homologous recombination deficiency (HRD) detection in breast cancer. Our method demonstrates prognostic value and predicts chemotherapy/PARP inhibitor sensitivity in HRD+ tumours.
Rong Zhu, Katherine Eason, Suet‐Feung Chin, Paul A. W. Edwards, Raquel Manzano Garcia, Richard Moulange, Jia Wern Pan, Soo Hwang Teo, Sach Mukherjee, Maurizio Callari, Carlos Caldas, Stephen‐John Sammut, Oscar M. Rueda   +12 more
wiley   +1 more source

A phase II study of preoperative chemoradiation with tegafur-uracil plus leucovorin for locally advanced rectal cancer with pharmacogenetic analysis

Radiation Oncology, 2017
Background This study aimed to evaluate the efficacy of a high dose of oral tegafur-uracil (400 mg/m2) plus leucovorin with preoperative chemoradiation of locally advanced rectal cancer and to explore the impact of polymorphisms of cytochrome P 2A6 ...
Sun Young Kim, Ji Yeon Baek, Jae Hwan Oh, Sung Chan Park, Dae Kyung Sohn, Min Ju Kim, Hee Jin Chang, Sun-Young Kong, Dae Yong Kim   +8 more
doaj   +1 more source

Physical activity and risks of breast and colorectal cancer: a Mendelian randomisation analysis

Nature Communications, 2020
Physical activity has been associated with lower risks of breast and colorectal cancer in epidemiological studies; however, it is unknown if these associations are causal or confounded.
N. Papadimitriou, N. Dimou, K. Tsilidis, B. Banbury, Richard M. Martin, S. Lewis, N. Kazmi, T. Robinson, D. Albanes, K. Aleksandrova, S. Berndt, D. Timothy Bishop, H. Brenner, D. Buchanan, B. Bueno-de-Mesquita, P. Campbell, S. Castellví-Bel, A. Chan, J. Chang-Claude, M. Ellingjord-Dale, J. Figueiredo, S. Gallinger, G. Giles, E. Giovannucci, S. Gruber, A. Gsur, J. Hampe, H. Hampel, Sophia Harlid, T. Harrison, M. Hoffmeister, J. Hopper, L. Hsu, José María Huerta, J. Huyghe, M. Jenkins, T. Keku, T. Kühn, C. la Vecchia, L. Le Marchand, Christopher I. Li, Li Li, A. Lindblom, N. Lindor, B. Lynch, S. Markowitz, G. Masala, A. May, R. Milne, E. Monninkhof, Lorena Moreno, V. Moreno, P. Newcomb, K. Offit, Vittorio Perduca, P. Pharoah, E. Platz, J. Potter, G. Rennert, E. Riboli, María-José Sánchez, S. Schmit, R. Schoen, G. Severi, S. Sieri, M. Slattery, M. Song, C. Tangen, S. Thibodeau, R. Travis, A. Trichopoulou, C. Ulrich, F. V. van Duijnhoven, B. van Guelpen, P. Vodicka, E. White, A. Wolk, M. Woods, A. Wu, U. Peters, M. Gunter, N. Murphy   +81 more
semanticscholar   +1 more source