Results 251 to 260 of about 789,387 (385)

Developing a New Stool Test for Colorectal Cancer Screening, the multitargetFIT (mtFIT). [PDF]

Dig Dis Sci
de Wit M, Dekker E, Spaander M, van Leerdam M, Coupe V, Meijer G, Carvalho B.   +6 more
europepmc   +1 more source

Branched‐Chain α Keto‐Acid Dehydrogenase Kinase‐Mediated AKT Phosphorylation Promotes RCC Tumorigenesis and Drug Resistance

Advanced Science, EarlyView.
This study identifies a novel oncogenic role and a previously unrecognized phosphorylation substrate of BCKDK in RCC, wherein it promotes tumor progression and drug resistance through AKT phosphorylation at both Thr308 and Ser473 sites and activation of AKT/mTOR and AKT/ABCB1 signaling pathways, offering a promising prognostic marker and therapeutic ...
Qin Tian, Jinxiang Wang, Qiji Li, Yangruiyu Liu, Yanping Chen, Jiacheng Feng, Zi‐Ning Lei, Harsh Patel, Chao‐Yun Cai, Yuzhi Xu, Chuntao Quan, Lingyan Fei, Zexiu Xiao, Shuo Fang, Tianxin Lin, Zhe‐Sheng Chen, Yuchen Liu, Leli Zeng, Yihang Pan   +18 more
wiley   +1 more source

Exploring ChatGPT effectiveness in addressing direct patient queries on colorectal cancer screening. [PDF]

Endosc Int Open
Maida M, Mori Y, Fuccio L, Sferrazza S, Vitello A, Facciorusso A, Hassan C.   +6 more
europepmc   +1 more source

USP10 Inhibits Ferroptosis via Deubiquinating POLR2A in Head and Neck Squamous Cell Carcinoma

Advanced Science, EarlyView.
This study identifies USP10 as a novel deubiquitinase that antagonizes ferroptosis in head and neck squamous cell carcinoma (HNSCC). Mechanistically, USP10 directly stabilizes POLR2A protein through post‐translational deubiquitination, enabling POLR2A‐mediated transcriptional activation of SLC7A11, a key ferroptosis inhibitor.
Diekuo Zhang, Xueying Wang, Shanhong Lu, Yan Gao, Gangcai Zhu, Guo Li, Zongnan Yu, Junwei Hou, Helei Yan, Wenhui Yuan, Xin Zhang, Mien‐Chie Hung, Zhifeng Liu, Yong Liu   +13 more
wiley   +1 more source

Cracking the Code of Colorectal Cancer Screening: An Overview With a Focus on Current and Emerging Screening Methods. [PDF]

Cureus
Boyapati HPN, Syeda STH, Saravanan A, Payidiparty D, Anbazhagan PK.   +4 more
europepmc   +1 more source

Serum 25‐hydroxyvitamin D, vitamin D binding protein and risk of colorectal cancer in the Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial

International Journal of Cancer, 2015
S. Weinstein, M. Purdue, S. Smith-Warner, A. Mondul, A. Black, Jiyoung Ahn, Wen-Yi Huang, R. Horst, W. Kopp, H. Rager, R. Ziegler, D. Albanes   +11 more
semanticscholar   +1 more source

Targeting Cystine Metabolism in the Lung Cancer Environment Enhances the Efficacy of Immune Checkpoint Inhibition

Advanced Science, EarlyView.
The tumor‐associated macrophages (TAMs) in lung cancer tissues exhibit active cystine metabolism. Restricting cystine concentration in macrophages induces M1 phenotypic polarization and upregulation of PD‐L1 expression through the GSH‐NF‐κB signaling pathway.
Yun Xu, Shumin Li, Jiaji Wu, Shumin Xu, Mo Shen, Chenyang Wang, Lundqvist Andreas, Jianghao Yu, Zhiyong Xu, Yueli Shi, Nana Liu, Yunke Yang, Jiangnan Zhao, Ying Yang, Pingli Wang, Peng Yi, Jin Cheng, Junhui Sun, Mengshu Li, Peng Xiao, Kai Wang   +20 more
wiley   +1 more source

Barriers and Facilitators to Colorectal Cancer Screening: Providers' Perspective. [PDF]

Asian Pac J Cancer Prev
AlAbdulKader A, Almansour AH, Abdulwahab A, Almomen A, Alhumran A, Alsaffar H, Alzaher M, AlKhater M.   +7 more
europepmc   +1 more source

Long-lasting reduction of risk of colorectal cancer following screening endoscopy [PDF]

, 2001
Hermann Brenner, Volker Arndt, Til Stürmer‎, C Stegmaier, H Ziegler, G. Dhom   +5 more
openalex   +1 more source

Epigenetic Activation of CCDC183‐AS1 Promotes Osteoclastogenesis and Prostate Cancer Bone Metastasis Through the FUBP1/LIGHT Axis

Advanced Science, EarlyView.
CCDC183‐AS1 overexpression enhanced the ability of PCa cells to spread to the bone by inducing osteoclastogenesis. Mechanistically, CCDC183‐AS1 interacted with FUBP1 and enhanced its stability, which promoted the transcription of TNFSF14 (LIGHT). Copy number gain‐induced KDM5C epigenetically upregulated CCDC183‐AS1 expression by recruiting TET1 to the ...
Chuandong Lang, Xiangyu Mu, Kun Chen, Xinwen Wang, Yuluo Rong, Jia Wang, Zongcheng Yang, Chi Yin, Yuhu Dai, Jun Xiao, Wenzhi Zhang   +10 more
wiley   +1 more source