Results 321 to 330 of about 789,387 (385)

Ubiquitination‐Dependent LLGL2 Degradation Drives Colorectal Cancer Progression via THBS3 mRNA Stabilization

Advanced Science, EarlyView.
During the progression of CRC, MDM2, as an E3 ubiquitin ligase, promotes the degradation of the LLGL2 protein. Reduced expression of the LLGL2 protein leads to the loss of support for the CNOT1 protein, decreasing the degradation of THBS3 mRNA. The increased THBS3 further activates the PI3K‐Akt pathway, promoting the proliferation and metastasis of CRC.
Jiayan Huang, Tiantian Zhang, Huimin Li, Zidan Li, Shuangshuang Yin, Yiman Liu, Chunze Zhang, Yuling Qiu, Haiyang Yu   +8 more
wiley   +1 more source

Difference-making factors for successful implementation of a multicomponent colorectal cancer screening program in rural clinics (SMARTER CRC). [PDF]

Front Med (Lausanne)
Petrik AF, Badicke B, Davis MM, Miech EJ, Coury J, Kenzie ES, Schneider JL, Durr R, Edelmann AC, Herreid-O'Neill A, Myers E, Coronado GD.   +11 more
europepmc   +1 more source

Ligilactobacillus Murinus and Lactobacillus Johnsonii Suppress Macrophage Pyroptosis in Atherosclerosis through Butyrate‐GPR109A‐GSDMD Axis

Advanced Science, EarlyView.
Oral aspirin administration induces intestinal expansion of Lactobacillus murinus and Lactobacillus johnsonii, which suppresses the progression of atherosclerosis. This microbial expansion significantly enhances butyrate production by providing lactate as a metabolic substrate, thereby fostering the growth of butyrate‐producing bacteria. Butyrate plays
Rui Hua, Ning Ding, Yiming Hua, Xiaoke Wang, Yu Xu, Xiangrui Qiao, Xue Shi, Ting Bai, Ying Xiong, Xiaozhen Zhuo, Chong Fan, Juan Zhou, Yue Wu, Junhui Liu, Zuyi Yuan, Ting Li   +15 more
wiley   +1 more source

The TET3/GATA6 Axis Drives Lipid Metabolism and Therapeutic Vulnerabilities in Pancreatic Ductal Adenocarcinoma

Advanced Science, EarlyView.
The DNA demethylase TET3 drives lipid metabolic reprogramming in pancreatic ductal adenocarcinoma via a non‐catalytic mechanism. TET3 recruits histone deacetylases to repress GATA6, sustaining lipogenic enzyme expression and ferroptosis resistance.
Shuai Liu, Shaobo Kang, Na Lin, Wenqi Zhang, Shiwen Wang, Yuqing Ren, Xiaofan Ding, Jianxiu Yu, Ruiyu Xie   +8 more
wiley   +1 more source

Optimal Stopping Ages for Colorectal Cancer Screening.

JAMA Netw Open
Harlass M, Dalmat RR, Chubak J, van den Puttelaar R, Udaltsova N, Corley DA, Jensen CD, Collier N, Ozik J, Lansdorp-Vogelaar I, Meester RGS.   +10 more
europepmc   +1 more source

Factors influencing colorectal cancer screening decisions among Saudi women: A qualitative study. [PDF]

PLoS One
Alsadhan N, Brennan C, Alhurishi SA, Shuweihdi F, West RM.   +4 more
europepmc   +1 more source

Utilization of molecular genetic approaches for colorectal cancer screening. [PDF]

World J Gastroenterol
Emelyanova MA, Ikonnikova AY.
europepmc   +1 more source

Advancing Non-Invasive Colorectal Cancer Screening: Exploring the Potential of Monoclonal Antibody L2A5. [PDF]

Int J Mol Sci
Caldevilla R, Eiras M, Santos DAR, Almeida J, Oliveira B, Loureiro S, Soares J, Gonzalez-Santos M, Ramos N, Videira PA, Santos LL, Dinis-Ribeiro M, Lima L.   +12 more
europepmc   +1 more source

Theory-based chatbot for promoting colorectal cancer screening in a community setting in Hong Kong: study protocol of a randomised controlled trial. [PDF]

BMJ Open
Hu Y, Lau WM, Wang ZJ, Tang RSY, Wu X, Mo PKH, Wong SYS, Meng MLH, Dong D, Sung JJY, Lam TYT.   +10 more
europepmc   +1 more source

Mediating effects of mental and physical health on the association between chronic disease conditions and colorectal cancer screening utilization among breast cancer survivors. [PDF]

PLoS One
Tsai MH, Vo JB, Moore JX, Ramin C, Guha A, Dong Y.   +5 more
europepmc   +1 more source