Results 121 to 130 of about 1,207,383 (287)

Repeat procedures for recurrent colorectal liver metastases: analysis of long-term liver regeneration and outcome

, 2019
Valentinus T Valdimarsson,1 Katarina Hellberg,2 Torkel B Brismar,3 Ernesto Sparrelid,2 Christian Sturesson1,21Department of Clinical Sciences Lund, Surgery, Lund University, Skane University Hospital, Lund, Sweden; 2Division of Surgery, Department of ...
Sparrelid E, Brismar TB, Hellberg K, Sturesson C, Valdimarsson VT   +4 more
core  

Metastasectomy of Combined Liver and Lung Colorectal Cancer Metastases

, 2015
The liver is the exclusive site of metastasis in approximately 30% to 50% of patients with stage IV colorectal cancer, whereas lung metastasis occurs in 10% to 20% of patients.
Abdalla, Eddie, Contreras, Carlo
core   +1 more source

Macrophage PABPC4‐SPP1 Axis Orchestrates Immunosuppression in Colorectal Cancer

Advanced Science, EarlyView.
In the CRC microenvironment, macrophage PABPC4 binds to the 3′UTR of SPP1 mRNA to stabilize its expression, thereby sustaining M2‐like immunosuppressive macrophage polarization. Concurrently, this axis suppresses CD8+ T cell effector functions via CD44 signaling, collectively fostering an immunosuppressive niche that drives tumor progression.
Meng Wang, Fang Yang, Yuan Gao, Liuli Li, Yulan Huang, Hui Yao, Sijie Zhao, Kun Zhao, Tianying Zhang, Hui Heng, Jiaxin Xu, Yuancai Xiang, Weidong Xiao, Shaofan Hu, Hongming Miao   +14 more
wiley   +1 more source

Treatment outcomes in colorectal cancer patients with synchronous liver metastases

Сибирский онкологический журнал
The purpose of the study was to analyze the 2-year survival rates in colorectal cancer (CRC) patients with synchronous liver metastases after combined modality treatment including perioperative chemotherapy.Material and Methods. A pilot prospective study
A. Yu. Dobrodeev, D. N. Kostromitsky, S. G. Afanasyev, A. S. Tarasova, N. N. Babyshkina, T. A. Dronova, A. A. Ponomareva, I. V. Larionova, S. V. Patalyak, N. V. Yunusova   +9 more
doaj   +1 more source

Corynoxine Inhibits Tumor Growth via Targeting NQO1 and Modulating the PTPA–NQO1/PP2A Switch to Activate PP2A

Advanced Science, EarlyView.
Corynoxine exerts potent broad‐spectrum anticancer activity by directly targeting NQO1. This interaction dissociates the oncogenic NQO1‐PTPA complex, releasing PTPA to robustly activate the tumor suppressor PP2A. Consequently, downstream Raf/MEK/ERK and PI3K/AKT signaling pathways are suppressed, downregulating c‐Myc and driving tumor regression ...
Guoqing Hou, Li Lin, Mengjie Xia, Ruohan Liang, Yueyue Zhang, Linna Du, Xuan Cao   +6 more
wiley   +1 more source

Postoperative complications after surgical treatment of colorectal liver metastases in the era of multimodal treatment

reservedThis study was conducted to evaluate the impact of different neoadjuvant chemotherapy regimens on morbidity and mortality after colorectal liver metastases (CRLM) resection or ...
ROSSI, SERENA
core  

Imaging Related To Transplantation For Colorectal Liver Metastases

, 2019
In this thesis patients who underwent liver transplantation (LT) for unresectable colorectal liver metastases were studied (SECA study). Lifelong immunosuppression following LT is necessary to prevent organ rejection and the general perception is that ...
Grut, Harald
core   +1 more source

Restoration of m6A‐Modified circPSMB1 Suppresses Chordoma Progression and Enables Local Nanotherapeutic Intervention

Advanced Science, EarlyView.
An m6A‐modified circRNA, circPSMB1, is identified as a tumor suppressor in chordoma. METTL3‐dependent m6A promotes circPSMB1 interaction with HNRNPA2B1, limiting c‐MYC expression and malignant progression. An injectable HMnO2‐based nanohydrogel enables local circPSMB1 delivery and tumor microenvironment‐responsive therapy, offering a promising strategy
Yingchuang Tang, Liang Qiu, Xingbang Ruan, Yihan Shi, Ye Wang, Hanwen Li, Kai Zhang, Kangwu Chen   +7 more
wiley   +1 more source

The Cancer Cell Metabolic Reprogramming Remodels the Tumor Microenvironment: Molecular Mechanisms and Therapeutic Strategies

Advanced Science, EarlyView.
This review elucidates how cancer cell metabolic reprogramming—across glucose, lipid, amino acid, and nucleotide pathways—remodels the tumor microenvironment to suppress anti‐tumor immunity and promote immune escape. Targeting these metabolic axes offers promising strategies to overcome immunotherapy resistance and enhance cancer treatment.
Guoqing Xiang, Zhicheng Zhou, Xue Jiang, Zhenguang Du, Yangyang Zhan, Xinli Liu   +5 more
wiley   +1 more source

Liver transplantation for non-resectable colorectal cancer metastases — a case report of long-term remission

Oncology in Clinical Practice
Colorectal cancer is the third most common malignancy worldwide. Metastases are present at diagnosis in 15–30% of patients, and 20–50% develop them during treatment. The liver is the most frequent site of spread.
Wiktoria Z. Ziółek, Michał Grąt, Maciej Krasnodębski, Waldemar Patkowski, Paweł M. Potocki   +4 more
doaj   +1 more source