Results 161 to 170 of about 332,251 (304)

Phase‐Separation of YAP Mediates AJUBA Super Enhancer Activation to Promote Aberrant Mitosis in Breast Cancer

Advanced Science, EarlyView.
YAP undergoes phase separation to activate the AJUBA super‐enhancer, driving aberrant mitosis through spindle checkpoint dysregulation in breast cancer. This study uncovers a mechanistic link between YAP condensates, super‐enhancer activation, and aneuploidy formation.
Rui Zhang, Qingwen Huang, Zhuo Chen, Weijian Meng, Hongliang Dong, Zhihong Qi, Liang Liu, Jie Shen, Daxing Xie   +8 more
wiley   +1 more source

The impact of renin-angiotensin system inhibitors on colorectal neoplasm development. [PDF]

Clin Hypertens
Han YM, Choi JM, Rhee TM, Choi SY, Lee H.   +4 more
europepmc   +1 more source

A Patient‐Derived Organoid Biobank of Adamantinomatous Craniopharyngioma as a Platform for Drug Discovery

Advanced Science, EarlyView.
This study successfully establishes adamantinomatous craniopharyngioma (ACP) patient‐derived organoids (PDOs) that preserve the histopathological and genetic features of the original tumors. Through drug sensitivity assays and subsequent mechanistic analyses, the study demonstrates that Ceritinib exerts its inhibitory effects on ACP PDO growth by ...
Huarong Zhang, Chaohu Wang, Jun Fan, Zexin Chen, Haoying Yu, Yawen Bai, Tingcheng Zhang, Qianchao Zhu, Yiwen Feng, Peirong Niu, Jiaqian Chen, Liping Yang, Xueying Li, Lei Yu, Songtao Qi, Yi Liu   +15 more
wiley   +1 more source

Impact of complete colonoscopy after ischaemic colitis onset on colorectal neoplasm detection in patients without suspected coexistence of colorectal cancer on computed tomography: a retrospective analysis. [PDF]

BMJ Open Gastroenterol
Kasuga K, Takeuchi Y, Katakai S, Hosoi A, Shimizu M, Yoshinari F, Kouga T, Isshiki A, Matsui A, Iizuka K, Ishihara S, Ueno T, Ma XH, Masuo T, Uraoka T.   +14 more
europepmc   +1 more source

Copy Number Alterations of Depressed Colorectal Neoplasm Predict the Survival and Response to Oxaliplatin in Proximal Colon Cancer. [PDF]

Cancers (Basel), 2020
Chang LC, Chiu HM, Ho BC, Chen MH, Hsu YC, Chiu WT, Su KY, Shun CT, Liang JT, Yu SL, Wu MS.   +10 more
europepmc   +1 more source

Helicobacter pylori infection and colorectal neoplasm [PDF]

QJM: An International Journal of Medicine, 2019
V H Chong, C F Chong
openaire   +2 more sources

Integrated Transcriptomics Reveals Evolutionary Trajectories and Cell Density‐Dependent Mechanisms in Aldosterone‐Producing Adenomas

Advanced Science, EarlyView.
Aldosterone‐producing adenomas (APAs) develop via two distinct paths: directly from adrenal zona glomerulosa (zG) cells, or stepwise from zG cells through aldosterone‐producing micronodules (APMs) before progressing to APAs. Advanced single‐cell and spatial analyses identified distinct cell states linked to oxidative stress and cell–cell interactions ...
Zhuolun Sun, Changying Jing, Martina Tetti, Siyuan Gong, Jia Wei, Yingxian Pang, Martin Reincke, Tracy Ann Williams   +7 more
wiley   +1 more source

FAPα+ Macrophages Orchestrate Immune Evasion in Multiple Myeloma by Dual Regulation of PD‐L1 and T Cell Senescence

Advanced Science, EarlyView.
ABSTRACT Multiple myeloma (MM) is a hematologic malignancy driven by clonal expansion of malignant plasma cells. Despite the long‐term disease control achieved with immunotherapies in some patients, treatment resistance remains a major cause of disease relapse.
Huiyao Gu, Zhenfeng Dai, Xi Huang, Enfan Zhang, Xinyuan Dai, Haoguang Chen, Wen Cao, Jinna Zhang, Yifan Hou, Haimeng Yan, Yang Yang, Li Yang, Yi Li, Wenlong Lin, Zhen Cai, Jingsong He   +15 more
wiley   +1 more source

Outcomes of Colorectal Endoscopic Submucosal Dissection According to the Size of Colorectal Neoplasm: A HASID Multicenter Study. [PDF]

In Vivo
Kim DH, Jin BC, Oh HH, Song HY, Kim SJ, Myung DS, Kim HS, Kim SW, Lee J, Joo YE, Seo GS.   +10 more
europepmc   +1 more source

Risk of Metachronous Colorectal Neoplasm after a Segmental Colectomy in Lynch Syndrome Patients According to Mismatch Repair Gene Status. [PDF]

J Am Coll Surg, 2020
Quezada-Diaz FF, Hameed I, von Mueffling A, Salo-Mullen EE, Catalano A, Smith JJ, Weiser MR, Garcia-Aguilar J, Stadler ZK, Guillem JG.   +9 more
europepmc   +1 more source