Results 111 to 120 of about 809,703 (372)

Quantile-based fecal hemoglobin concentration for assessing colorectal neoplasms with 1,263,717 Taiwanese screenees

open access: yesBMC Medical Informatics and Decision Making, 2019
Background Although fecal hemoglobin concentration (f-Hb) was highly associated with the risk of colorectal neoplasms, current studies on this subject are hampered by skewedness of the data and the ordinal property of f-Hb has not been well studied yet ...
Szu-Min Peng   +9 more
doaj   +1 more source

Targeting the MDM2‐MDM4 interaction interface reveals an otherwise therapeutically active wild‐type p53 in colorectal cancer

open access: yesMolecular Oncology, EarlyView.
This study investigates an alternative approach to reactivating the oncosuppressor p53 in cancer. A short peptide targeting the association of the two p53 inhibitors, MDM2 and MDM4, induces an otherwise therapeutically active p53 with unique features that promote cell death and potentially reduce toxicity towards proliferating nontumor cells.
Sonia Valentini   +10 more
wiley   +1 more source

Head-to-Head Comparison of the Performance of 17 Risk Models for Predicting Presence of Advanced Neoplasms in Colorectal Cancer Screening

open access: yesAmerican Journal of Gastroenterology, 2019
OBJECTIVES: Many risk scores have been proposed to predict presence of advanced colorectal neoplasms, but a comprehensive comparison conducted in the same population is sparse.
Le Peng   +4 more
semanticscholar   +1 more source

[Blood gastrin and colorectal neoplasms].

open access: yesIl Giornale di chirurgia, 1994
Gastrin has a trophic effect on the mucosa of the gastrointestinal tract and seems to have the potential for promoting colonic cancerogenesis through a chronic stimulation of the epithelial proliferation. Plasma gastrin has been reported to be elevated in patients with colorectal neoplasms.
CIVITELLI, SERENELLA   +7 more
openaire   +2 more sources

Elucidating prognostic significance of purine metabolism in colorectal cancer through integrating data from transcriptomic, immunohistochemical, and single‐cell RNA sequencing analysis

open access: yesMolecular Oncology, EarlyView.
Low expression of five purine metabolism‐related genes (ADSL, APRT, ADCY3, NME3, NME6) was correlated with poor survival in colorectal cancer. Immunohistochemistry analysis showed that low NME3 (early stage) and low ADSL/NME6 (late stage) levels were associated with high risk.
Sungyeon Kim   +8 more
wiley   +1 more source

On tumor development: fractional transport approach [PDF]

open access: yesarXiv, 2004
A growth of malignant neoplasm is considered as a fractional transport approach. We suggested that the main process of the tumor development through a lymphatic net is fractional transport of cells. In the framework of this fractional kinetics we were able to show that the mean size of main growth is due to subdiffusion, while the appearance of ...
arxiv  

Automatic Polyp Segmentation using U-Net-ResNet50 [PDF]

open access: yesarXiv, 2020
Polyps are the predecessors to colorectal cancer which is considered as one of the leading causes of cancer-related deaths worldwide. Colonoscopy is the standard procedure for the identification, localization, and removal of colorectal polyps. Due to variability in shape, size, and surrounding tissue similarity, colorectal polyps are often missed by ...
arxiv  

Non-polypoid colorectal neoplasms: Classification, therapy and follow-up.

open access: yesWorld Journal of Gastroenterology, 2015
In the last years, an increasing interest has been raised on non-polypoid colorectal tumors (NPT) and in particular on large flat neoplastic lesions beyond 10 mm tending to grow laterally, called laterally spreading tumors (LST).
A. Facciorusso   +4 more
semanticscholar   +1 more source

The atypical KRASQ22K mutation directs TGF‐β response towards partial epithelial‐to‐mesenchymal transition in patient‐derived colorectal cancer tumoroids

open access: yesMolecular Oncology, EarlyView.
TGF‐β has a complex role in cancer, exhibiting both tumor‐suppressive and tumor‐promoting properties. Using a series of differentiated tumoroids, derived from different stages and mutational background of colorectal cancer patients, we replicate this duality of TGF‐β in vitro. Notably, the atypical but highly aggressive KRASQ22K mutation rendered early‐
Theresia Mair   +17 more
wiley   +1 more source

Modifiable factors of development and recurrence of adenomatous colorectal polyps (literature review)

open access: yesВестник медицинского института «Реавиз»: Реабилитация, врач и здоровье
Relevance. Adenomatous colorectal polyps are associated with a high risk of developing a malignant tumor. They are considered precancerous conditions and can lead to the development of colorectal cancer.
I. G. Gataullin   +4 more
doaj   +1 more source

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