Results 301 to 310 of about 366,130 (353)

Smohaze‐Upregulated RFWD3 Competes with TRIM24 to Stabilize TREX1 and Reduce Cytosolic dsDNA in Non‐Small Cell Lung Cancer

Advanced Science, EarlyView.
The E3 ubiquitin ligase RFWD3 binds the exonuclease TREX1 and protects it from TRIM24‐mediated ubiquitination and degradation, leading to the eradication of intracellular dsDNA, inhibition of the cGAS‐STING pathway, and immunosuppressive microenvironment of lung cancer.
Xue‐Yan Shi, Yu‐Ke Shen, Meng‐Yao Lv, Yu Sun, Yong‐Fang Lin, Zheng Wang, Xiao‐Liang Jie, Zheng Liu, Yang‐Tong Liu, Yang‐Xin Fu, Zhenhua Ren, Gui‐Zhen Wang, Guang‐Biao Zhou   +12 more
wiley   +1 more source

SNORA58 Facilitates Radioresistance via Suppressing JNK1‐Mediated Ferroptosis in Esophageal Squamous Cell Carcinoma

Advanced Science, EarlyView.
In ESCC patients, SNORA58 exhibits heterogeneous expression patterns. Its aberrant overexpression stabilizes CTCF by inhibiting ubiquitin‐mediated degradation, leading to the attenuation of JNK1‐mediated ferroptosis induced by radiotherapy through disruption of intracellular iron homeostasis, and ultimately contributes to radioresistance ...
Yinli Zheng, Fangyi Liu, Yuhua Huang, Yanfen Feng, Xia Yang, Jinjun Wu, Xin Yang, Xuanhao Lin, Lives Jiang, Tingting Zeng, Yan Li, Xinyuan Guan, Yuanyuan Wang, Chunyan Chen, Jingping Yun   +14 more
wiley   +1 more source

Self‐Propelled Magnetic Micromotor‐Functionalized DNA Tile System for Autonomous Capture of Circulating Tumor Cells in Clinical Diagnostics

Advanced Science, EarlyView.
The magnetic micromotor‐functionalized DNA‐array hunter (MMDA hunter), integrating autonomous propulsion and precision‐partitioned functionalities, utilizes DNA array programmability and 5'‐3' directional control to achieve spatially partitioned module arrangement.
Qiumei Pu, Liangqing Lu, Yanghong Zhao, Dongxia Li, Mengli Yao, Qionglin Zhou, Xinxin Xiao, Yuzhong Jia, Xuan Zhao, Xiangde Lai, Qian Chen, Yuxiang Ji, Bin Qiao, Hua Pei, Yanan Peng, Qiang Wu   +15 more
wiley   +1 more source

Hsa_circ_0026782 Acts as a “Molecular Break” of CREB1‐Mediated Transcription by Promoting Its Phosphorylation at Ser142 That Prevents Keloid Progression

Advanced Science, EarlyView.
Model for the role of hsa_circ_0026782/p‐CREB1 (Ser142) played in keloid. Hsa_circ_0026782 is derived from back‐splicing of ITGA7 exon 4. When hsa_circ_0026782 binds to CREB1, the exposure of the bZIP domain and dimerization of CREB1 are promoted (upper left).
Xin‐Cao Zhong, Chun‐Ye Chen, Zi‐Xuan Feng, Yong Wang, Tao Zhang, Ze‐Ming Zhuang, Zhang‐Rui Wu, Yong‐Zhong Du, Jun Chen, Xiao‐Ying Lin, Wei‐Qiang Tan   +10 more
wiley   +1 more source

CircLRBA Promotes Epithelial‐Mesenchymal Transition, Immune Evasion, Chemoimmunotherapy Resistance and Metastasis Through Stabilizing Twist1

Advanced Science, EarlyView.
CircLRBA is highly expressed in breast cancer (BC) and associated with poor overall survival. Zeb1 mediated circLRBA facilitates BC cell proliferation, invasion, docetaxel (DTX) resistance and inhibits the infiltration of CD8+ T cell. CircLRBA could combine with SPOP to suppress the Twist1 ubiquitination degradation and enhances PD‐L1 transcription ...
Xiaosong Wang, Xin Yang, Lei Xing, Hang Chen, Fuming Xie, Bin Wang, Bowen Shi, Yan Yang, Junxia Chen   +8 more
wiley   +1 more source

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Colorectal neoplasm and acromegaly

Pituitary, 2006
The risk for colorectal carcinoma in acromegaly remains controversial. In our earlier study, we have demonstrated that the risk of colorectal carcinoma in Asian Indians with acromegaly is not increased and after this report, routine colonoscopy in our patients with acromegaly was abandoned.
R Kochar, Saroj K. Sinha, Anil Bhansali, K Vaiphi, Mohammad Hayat Bhat, Pinaki Dutta   +5 more
openaire   +3 more sources

Atypical Colorectal Neoplasms

Surgical Clinics of North America, 2017
Primary colorectal lymphoma, carcinoids (neuroendocrine tumors), and gastrointestinal stromal tumors comprise a small subset of all colorectal cancers. Their features are unique, and their treatment varies from that of colorectal adenocarcinoma. Appropriate identification is key in the management of these tumors.
Scott M. Stoeger, Michael G Porter
openaire   +3 more sources

Laparoscopic surgery for colorectal neoplasms

Seminars in Surgical Oncology, 1994
AbstractLaparoscopy is being used to assist in an increasing number and variety of bowel procedures. However, when being used for neoplastic disease concerns of margins and adequacy of mesenteric dissection must be addressed. We've performed 110 laparoscopic‐assisted bowel procedures, with 45 of these performed for neoplastic disease.
Marion E. Schertzer, Guy R. Orangio, David Armstrong, George W. Lucas, Wayne L. Ambroze   +4 more
openaire   +3 more sources

Origins and morphogenesis of colorectal neoplasms

APMIS, 1999
Gastrointestinal stem cells are considered pivotal in colonic carcinogenesis. There is evidence to suggest that early microadenomas in the colon are polyclonal in origin. Adenomas, once initiated, enlarge by the process of crypt fission. It is also the main mechanism by which neoplastic clones spread through the colorectal epithelium. Both concepts are
Nicholas A. Wright, Sérgio Britto Garcia, Wai Man Wong, Wai Man Wong   +3 more
openaire   +3 more sources