Results 321 to 330 of about 855,584 (391)

Colorectal Cancer Cells–Derived Exosomal PIK3CA Mutation DNA Promotes Tumor Metastasis by Activating Fibroblast and Affecting Tumor Metastatic Microenvironment

Advanced Science, EarlyView.
PIK3CAH1047R DNA in colorectal cancer (CRC) cell‐derived exosomes can be delivered into recipient fibroblasts, where it is transcribed and translated, leading to the activation of fibroblasts into cancer‐associated fibroblasts, which secrete elevated levels of IL6. The simultaneous detection and targeting of PIK3CAH1047R mutation and IL6 may serve as a
Rui Wang, Wanming Li, Yuqiong Lv, Wei Ba, Ying Jiang, Xiaoshuai Li, Jin Fang   +6 more
wiley   +1 more source

DON‐Loaded Nanodrug‐T Cell Conjugates With PD‐L1 Blockade for Solid Tumor Therapy

Advanced Science, EarlyView.
This study establishes DON‐loaded T cell‐nanodrug conjugates with PD‐L1 blockade, creating a synergistic system. As a glutamine antagonist, sustained DON release enhances T‐cell endurance and infiltration by promoting memory differentiation and upregulating adhesion and motility genes, while PD‐L1 blockade alleviates immunosuppression and directs T ...
Xin Yang, Xiaoshuang Niu, Ye Su, Xiaoyun Ye, Wanqiong Li, Wenxuan Zeng, Xin Zhao, Zhuoying He, Qingyu Dong, Xiuman Zhou, Xinghua Sui, Guanyu Chen, Yanfeng Gao, Juan Liu   +13 more
wiley   +1 more source

Genetic Regulation of Alternative Polyadenylation Provides Novel Insights into Molecular Mechanisms Underlying Non‐small Cell Lung Cancer

Advanced Science, EarlyView.
Compared with the non‐risk G allele of rs9606, the risk T allele of rs9606 decreases the binding affinity of NUDT21 for LYRM4, triggering 3'UTR shortening that stabilizes LYRM4 mRNA and elevates its expression. Increased LYRM4 expression promoted malignant phenotypes of non‐small cell lung cancer (NSCLC) cells through modulating ferroptosis, supporting
Meng Jin, Yongbiao Huang, Bin Li, Yuan Wang, Yan Li, Zhirui Chen, Zhe Tang, Chaofan Liu, Lei Zhang, Xianglin Yuan, Jianbo Tian, Bo Liu   +11 more
wiley   +1 more source

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Atypical Colorectal Neoplasms

Surgical Clinics of North America, 2017
Primary colorectal lymphoma, carcinoids (neuroendocrine tumors), and gastrointestinal stromal tumors comprise a small subset of all colorectal cancers. Their features are unique, and their treatment varies from that of colorectal adenocarcinoma. Appropriate identification is key in the management of these tumors.
Scott M. Stoeger, Michael G Porter
openaire   +4 more sources

Nomogram Prediction of Metachronous Colorectal Neoplasms in Patients With Colorectal Cancer

Annals of Surgery, 2015
To construct a predictive model of postoperative colorectal neoplasm development using a nomogram.Although patients with colorectal cancer (CRC) are known to be at high risk of developing metachronous adenoma or CRC, no statistical model for predicting the incidence of postoperative colorectal lesions has been reported.A total of 309 CRC patients who ...
Hiroaki Miyata, Hironori Yamaguchi, Kazushige Kawai, Joji Kitayama, Eiji Sunami, Soichiro Ishihara, Toshiaki Watanabe   +6 more
openaire   +4 more sources

Outcomes of endoscopic submucosal dissection for colorectal neoplasms: Prospective, multicenter, cohort trial

Digestive Endoscopy, 2021
Endoscopic mucosal resection (EMR) is the gold standard for the treatment of noninvasive large colorectal lesions, despite challenges associated with nonlifting lesions and a high rate of local recurrence.
N. Kobayashi, Y. Takeuchi, K. Ohata, M. Igarashi, M. Yamada, S. Kodashima, K. Hotta, K. Harada, H. Ikematsu, T. Uraoka, Naoto Sakamato, H. Doyama, T. Abe, A. Katagiri, S. Hori, T. Michida, T. Yamaguchi, M. Fukuzawa, S. Kiriyama, K. Fukase, Y. Murakami, H. Ishikawa, Yutaka Saito   +22 more
semanticscholar   +1 more source

Colorectal neoplasm and acromegaly

Pituitary, 2006
The risk for colorectal carcinoma in acromegaly remains controversial. In our earlier study, we have demonstrated that the risk of colorectal carcinoma in Asian Indians with acromegaly is not increased and after this report, routine colonoscopy in our patients with acromegaly was abandoned.
R Kochar, Saroj K. Sinha, Anil Bhansali, K Vaiphi, Mohammad Hayat Bhat, Pinaki Dutta   +5 more
openaire   +3 more sources

Laparoscopic surgery for colorectal neoplasms

Seminars in Surgical Oncology, 1994
AbstractLaparoscopy is being used to assist in an increasing number and variety of bowel procedures. However, when being used for neoplastic disease concerns of margins and adequacy of mesenteric dissection must be addressed. We've performed 110 laparoscopic‐assisted bowel procedures, with 45 of these performed for neoplastic disease.
Marion E. Schertzer, Guy R. Orangio, David Armstrong, George W. Lucas, Wayne L. Ambroze   +4 more
openaire   +3 more sources

Origins and morphogenesis of colorectal neoplasms

APMIS, 1999
Gastrointestinal stem cells are considered pivotal in colonic carcinogenesis. There is evidence to suggest that early microadenomas in the colon are polyclonal in origin. Adenomas, once initiated, enlarge by the process of crypt fission. It is also the main mechanism by which neoplastic clones spread through the colorectal epithelium. Both concepts are
Nicholas A. Wright, Sérgio Britto Garcia, Wai Man Wong, Wai Man Wong   +3 more
openaire   +3 more sources