Results 191 to 200 of about 3,282,422 (392)

Association of the tumor microenvironment collagen score and immunoscore with colon cancer lymph node metastasis

BMC Cancer
Background In clinical practice, lymph node status has an important impact on colon cancer (CC) management and treatment. The role of the tumor microenvironment collagen score and immunoscore in colon cancer lymph node metastasis remains unknown. Methods
Chenyan Long, Jiaxin Cheng, Mingyuan Feng, Botao Yan, Yiran Li, Wei Jiang, Dexin Chen, Jun Yan   +7 more
doaj   +1 more source

Small Nucleolar RNA Snord17 Promotes Self‐Renewal of Intestinal Stem Cells through Yy2 mRNA Export and Tead4 Activation

Advanced Science, EarlyView.
Snord17, through interaction with Thoc3, promotes nuclear export and translation of Yy2 mRNA in Snord17+/+ ISCs. The Yy2 protein subsequently binds the Tead4 promoter to promote its transcription, activating Hippo signaling, which is essential for ISC maintenance.
Peikang Zhang, Yuwei Xu, Yufei Lan, Zhen Xiong, Zhibin Yi, Runyuan Wu, Cunzhen Li, Ying Du, Hui Guo, Yingchi Yang, Zusen Fan   +10 more
wiley   +1 more source

Secondary Perianal Paget’s Disease Originating From Adenocarcinoma of the Anorectal Junction: A Case Report

Clinical, Cosmetic and Investigational Dermatology
Jun He,1,* Rong-Chao He,2,* Jian-Zhong Peng,3 Hou-Dong Wang,1 Tao Wang,3 Si-Jia Lu,4 Xiu-Feng Zhang,1 Zhong Shen1 1Department of Colorectal Surgery, Hangzhou Third People’s Hospital, Hangzhou, Zhejiang, People’s Republic of China; 2School
He J, He RC, Peng JZ, Wang HD, Wang T, Lu SJ, Zhang XF, Shen Z   +7 more
doaj  

ROLE OF ANTIBIOTICS IN ELECTIVE COLORECTAL SURGERY

, 2020
Vijendra Kirnake, Abhijit Deshmukh
openalex   +2 more sources

Beyond Catalytic Therapy: Copper‐Paeonol Nanozymes Disrupt Fascin‐Mediated Actin Bundling to Suppress Tumor Growth and Metastasis

Advanced Science, EarlyView.
Copper‐paeonol nanozymes target tumor‐specific reactive oxygen species generation and disrupt fascin‐mediated actin bundling, effectively suppressing tumor growth and metastatic colonization. Abstract Fascin, an actin‐bundling protein universally upregulated in metastatic tumors, drives tumor migration and invasion by promoting filopodia and ...
Peiying Zhang, Huajun Li, Yisen Wang, Jie Xiang, Lei Fan, Shengzhe Zhang, Lizeng Gao, Hua Dai, Juqun Xi   +8 more
wiley   +1 more source

Minimally invasive versus open surgery among colorectal cancer patients [PDF]

Renjith Mathew, Jaya Shankar Kaushik, Sandeep Kumar, Swaroop Gopal, Saoji Ajeet, P. Perumal, Shoraf Pascal   +6 more
openalex   +1 more source

Antigen-Directed Cancer Surgery for Primary Colorectal Cancer: 15-Year Survival Analysis [PDF]

, 2017
J. P. Tiernan, David Jayne
openalex   +1 more source

Spatial Profiling Reveals Distinct Molecular and Immune Evolution of Mouse Lung Adenocarcinoma Precancers with or Without Carcinogen Exposure

Advanced Science, EarlyView.
Tumor evolution in lung adenocarcinoma is shaped by genetic alterations and spatial immune dynamics. By integrating whole‐exome sequencing, imaging mass cytometry, and spatial transcriptomics across two mouse models, this study reveals how mutational burden, immune infiltration, and cell–state interactions evolve during early and late carcinogenesis ...
Bo Zhu, Muhammad Aminu, Pingjun Chen, Jian‐Rong Li, Chuanpeng Dong, Chenyang Li, Yanhua Tian, Shao‐Wei Lu, Hong Chen, Chenxi Ma, Xin Hu, Jie Ye, Andrew Y. Liu, Beibei Huang, Frank R. Rojas, Parra Cuentas. Edwin Roger, Ou Shi, Monique B. Nilsson, Alissa Poteete, Khaja B. Khan, Wei Lu, Luisa M. Solis Soto, Junya Fujimoto, Cara Haymaker, Ignacio I. Wistuba, Zhubo Wei, Linghua Wang, Don L. Gibbons, Ken Chen, Alexandre Reuben, Jason M. Schenkel, John V. Heymach, Chao Cheng, Jia Wu, Jianjun Zhang   +34 more
wiley   +1 more source

PBRM1 Deficiency Reshapes an Immune Suppressive Microenvironment Through Epigenetic Tuning of PBRM1‐KDM5C‐IL6 Axis in ccRCC

Advanced Science, EarlyView.
PBRM1 ranks as the second most commonly mutated gene in ccRCC. This study reveals that PBRM1 loss promotes an immunosuppressive microenvironment by elevating M2 TAMs via the KDM5C–IL‐6 axis. These M2 TAMs, along with CAFs, form a barrier that excludes CD8+ T cells. Targeting IL‐6 synergizes with anti‐PD1 therapy, offering a promising strategy for PBRM1‐
Wenjiao Xia, Hongru Wang, Yu Dong, Zitong Yang, Yiyang Zhou, Zhinan Xia, Qinchen Li, Liangliang Ren, Yichun Zheng, Junliang Yan, Dongmei Ma, Zhi Chen, Xingang Cui, Guixin Zhu, Cheng Zhang   +14 more
wiley   +1 more source

Ergonomic hand positioning overcomes visual perception mismatch in nonsimulated robotic colorectal surgery [PDF]

Shing Wai Wong, Ranah Lim, Xiuling Jasmine Wong, Philip Crowe   +3 more
openalex   +1 more source