Results 171 to 180 of about 1,849,576 (300)

Targeting the KAT7/H3K14ac/RAC2 Axis Mediates OXPHOS to Promote Stemness Maintenance and Malignancy in Glioblastoma

Advanced Science, EarlyView.
SOX2 upregulates KAT7 in glioma stem cells, where KAT7 deposits H3K14 acetylation at the RAC2 promoter to activate RAC2 transcription. RAC2‐GTP subsequently promotes PAK1/2/3 phosphorylation, increasing tricarboxylic acid cycle flux and mitochondrial respiration to support glioblastoma malignancy.
Jilong Liu, Yanfei Sun, Yuehua Zhu, Guangjing Mu, Jiazheng Wang, Liangliang Wang, Feihu Zhao, Zhimin Zhao, Jian Wang, Ying He, Zheng Jiang, Xingang Li, Mingzhi Han, Bin Huang   +13 more
wiley   +1 more source

Prehabilitation and postoperative outcomes in colorectal surgery: an umbrella review. [PDF]

J Anesth Analg Crit Care
Tadesse MA, Alimawu AA, Matrisch L, Abebe MM, Techale K, Bekele Z, Alemu EA.   +6 more
europepmc   +1 more source

Leveraging Microphysiological Systems to Facilitate Neutrophil‐Based Cancer Immunotherapy

Advanced Science, EarlyView.
Microphysiological systems are emerging as powerful human‐relevant platforms for studying neutrophil biology in cancer. Current applications of spheroids, organoids, and organ‐on‐a‐chip models are reviewed, together with future opportunities in behaviorome profiling, multi‐omics integration, personalized medicine, immune crosstalk, and multi‐organ ...
Shuai Shao, Markus Isfeld Diehl, Caroline N. Jones   +2 more
wiley   +1 more source

New persistent opioid use after colorectal surgery in Sweden: A nationwide register-based cohort study. [PDF]

Colorectal Dis
Gedda C, Nygren J, Sturegård E, Wang Y, Thorell A, Soop M.   +5 more
europepmc   +1 more source

SOX30 Facilitates Triple‐Negative Breast Cancer Metastasis via TNFR2–NF‐κB Signaling and Tumor Microenvironment Remodeling

Advanced Science, EarlyView.
SOX30 drives triple‐negative breast cancer (TNBC) metastasis through a dual mechanism: direct activation of the TNFR2/NF‐κB signaling cascade and subsequent CCL20‐mediated recruitment of tumor‐associated macrophages (TAMs) into the tumor microenvironment.
Pingping Gao, Na Sun, Ning Yang, Tingting Zhao, Rui Fu, Zhenyu Wu, Yuqin Zhou, Xuanni Tan, Yi Zhang, Fei Han, Xiaowei Qi   +10 more
wiley   +1 more source

ZIF-8 Nanocarrier-Based Co-Delivery of Curcumin and 5-Fluorouracil for Synergistic Antitumor Activity in Hepatocellular Carcinoma

International Journal of General Medicine
Long Zhang,1,* Weijie Zhu,2,* Lei He,3,* Yuehan Zhang,2 Haibo Yang,2 Jinbao Xiao,4 Jiayi Zhao,2 Yunfei Huang,1 Jiannan Li21Department of Hepatobiliary Surgery, Siping City Central People’s Hospital, Siping City, Jilin Province ...
Zhang L, Zhu W, He L, Zhang Y, Yang H, Xiao J, Zhao J, Huang Y, Li J   +8 more
doaj  

From Recognition to Prevention: Modern Approaches to Complication Reduction in Colorectal Surgery. [PDF]

J Clin Med
Yeh YT, Sriram N, Yanagisawa W.
europepmc   +1 more source

Collagen‐Binding IL‐15 Immunocytokine Armed Oncolytic Adenovirus Establishes a Self‐Reinforcing Immunostimulatory Milieu to Potentiate Antitumor Immunity

Advanced Science, EarlyView.
Repurposing the dense tumor stroma from a physical barrier into an anchoring scaffold, an engineered oncolytic adenovirus encoding IL15C‐CBD overcomes the immunosuppressive microenvironment in triple‐negative breast cancer. Intratumoral viral replication secretes this collagen‐anchored immunocytokine, forming a localized cytokine depot.
Yaqi Yang, Xiaoxiao Liu, Junqiang Ding, Jinliang Xu, Jianhua Zhang, Hanchang Zhang, Rong Yang, Sha Li, Lu Zheng, Runping Su, Yue Zhao, Jianxiao Wu, Hao Li, Changyou Zhan, Xihui Gao   +14 more
wiley   +1 more source

Contemporary preoperative assessment for colorectal surgery: new insights and developments. [PDF]

BMJ Open Gastroenterol
Ong J, Wylie M, Dunlop MG, Ventham NT.
europepmc   +1 more source

Biomimetic Scaffold‐Based 3D Models for Decoding Cancer Biology and Advancing Therapy

Advanced Science, EarlyView.
A timeline of the research history of 3D biomimetic scaffold materials and platforms. With advances in biomimetic materials and 3D scaffold technologies, their functional scope has expanded from mimicking basic physical and biochemical properties to increasingly replicating complex pathophysiological processes.
Haitao Zhao, Yuechen Han, Jie Li, Peng Luo, Lin Qi, Zhiwei Xia, Xiaosong Li, Quan Cheng, Chenshen Huang, Wantao Wu, Hao Zhang   +10 more
wiley   +1 more source