Results 161 to 170 of about 3,606,891 (358)

Leveraging Artificial Intelligence and Large Language Models for Cancer Immunotherapy

Advanced Science, EarlyView.
Cancer immunotherapy faces challenges in predicting treatment responses and understanding resistance mechanisms. Artificial intelligence (AI) and machine learning (ML) offer powerful solutions for cancer immunotherapy in patient stratification, biomarker discovery, treatment strategy optimization, and foundation model development.
Xinchao Wu, Mengtao Sun, Lusheng Li, Jieqiong Wang, Shibiao Wan   +4 more
wiley   +1 more source

Effect of sex differences on the emergence of ctDNA RAS mutations in RAS wild-type colorectal cancer

Scientific Reports
In some cases of RAS wild-type metastatic colorectal cancer (mCRC), mutant RAS may emerge during chemotherapy. This study aimed to identify the clinicopathological factors associated with the emergence of RAS mutations during treatment.
Kenta Iguchi, Mamoru Uchiyama, Masahiro Asari, Koji Numata, Manabu Shiozawa   +4 more
doaj   +1 more source

Colorectal Surgery as a Specialty [PDF]

Journal of the Royal Society of Medicine, 1996
openaire   +3 more sources

Enhancing CAR‐T Cell Efficacy in Solid Tumors by Inhibiting CCL5/VEGF‐Mediated Angiogenesis

Advanced Science, EarlyView.
This study reveals that CAR‐T cells in solid tumors produce CCL5, which paradoxically induces VEGF and angiogenesis to promote tumor growth. Blocking CCL5/VEGF signaling—through gene knockout, or the CCR5 inhibitor maraviroc—significantly enhances the antitumor efficacy of CAR‑T therapy (the diagram was created in Biorender).
Shishuo Sun, Qihong Li, Bixi Wang, Gang Wang, Ying Xue, Yibing Liang, Chenhe Hu, Zhenyu Wang, Xiaoge Gao, Haiheng Xu, Jun Song, Hailong Li, Liantao Li, Xiaoxiao Liu, Patrick Ming‐Kuen Tang, Qing Zhang   +15 more
wiley   +1 more source

A preoperative MRI pelvic multiparameter nomogram for predicting sphincter preservation and operative difficulty in laparoscopic total mesorectal excision for ultra-low rectal cancer

BMC Surgery
Background Sphincter preservation (SP) during laparoscopic total mesorectal excision (LaTME) for low rectal cancer is challenged by a deep, narrow pelvis. Robust, MRI-based predictors for both SP success and operative difficulty are lacking.
Haipeng Jin, Qian Zhang, Longhai Feng, Rongbiao Ying, Haixing Ju   +4 more
doaj   +1 more source

Epithelial TRIM27 Inhibits Intestinal Inflammation in Ulcerative Colitis by the USP7/TRIM27‐IKK Double Negative‐Feedback

Advanced Science, EarlyView.
ABSTRACT The E3 ubiquitin ligase tripartite motif 27 (TRIM27) is a negative regulator of NF‐κB activation and the innate immune response, and TRIM27 deficiency significantly impairs dextran sulfate sodium (DSS)‐induced colitis. The function of TRIM27 in intestinal epithelial cells (IECs), the mechanism by which TRIM27 inhibits the NF‐κB pathway and its
Weimin Xu, Zhebin Hua, Zhujiang Dai, Shasha Zhang, Yihan Jiang, Wensong Ge, YingWei Chen, Zhongchuan Wang, Bing Zhang, Chen‐Ying Liu, Peng Du   +10 more
wiley   +1 more source

The Development and Pilot Clinical Study of CD147 Targeted Antagonistic Peptide Probe for Tumor Imaging

Advanced Science, EarlyView.
This study establishes [68Ga]Ga‐DOTA‐AP9 as a first‐in‐human CD147‐targeted PET tracer with favorable safety and specific tumor uptake. Tracer accumulation correlates with CD147 expression in patients, enabling noninvasive quantification of CD147‐positive malignancies.
Xiaokun Ma, Rui Guo, Dongfeng Niu, Yufei Song, Zhenyao Zhang, Xiangxi Meng, Lili Mao, Haifeng Huang, Hua Zhu, Zhi Yang, Teli Liu   +10 more
wiley   +1 more source

Correction: Colonic medullary carcinoma: an exceedingly rare type of colorectal malignancy: a case report and review of the literature

Journal of Medical Case Reports, 2023
Fajer Al‑Ishaq, Mahmood Al‑Dhaheri, Ali Toffaha, Salwa Awad, Syed Rizvi, Mohamed AbuNada, Mohamed Kurer   +6 more
doaj   +1 more source

Identification of PANoptosis associated lncRNAs associated with clinical prognosis and immune infiltration microenvironment in colon adenocarcinoma

Discover Oncology
Early diagnosis and disease management based on risk stratification have a very positive impact on colon adenocarcinoma (COAD) prognosis. It is of positive significance to further explore risk stratification of COAD patients and identify predictive ...
Yangyang Wang, Shihui Zhao, Songtao Du, Tianyi Xia, Liqiang Song, Mingyu Xia, Bomiao Zhang   +6 more
doaj   +1 more source

EEPD1 Inhibition Unleashes Antitumor Immunity in Colorectal Cancer by Activating the cGAS‐STING Pathway

Advanced Science, EarlyView.
In colorectal cancer, high expression of the DNA repair protein EEPD1 correlates with immune exclusion and poor prognosis. This study demonstrates that EEPD1 depletion induces genomic instability, leading to cytosolic DNA accumulation and subsequent activation of the cGAS‐STING‐type I interferon pathway. This cascade remodels the tumor microenvironment
Liyun Huo, Chong Wu, Xiaobo Li, Caina Ma, Jiamin Huang, Zishuo Chen, Weiling He, Tianyu Tao, Weijing Zhang   +8 more
wiley   +1 more source