Results 141 to 150 of about 272,839 (312)

Identification of PANoptosis associated lncRNAs associated with clinical prognosis and immune infiltration microenvironment in colon adenocarcinoma

Discover Oncology
Early diagnosis and disease management based on risk stratification have a very positive impact on colon adenocarcinoma (COAD) prognosis. It is of positive significance to further explore risk stratification of COAD patients and identify predictive ...
Yangyang Wang, Shihui Zhao, Songtao Du, Tianyi Xia, Liqiang Song, Mingyu Xia, Bomiao Zhang   +6 more
doaj   +1 more source

Neuron‐Derived MIF Engages VCAM1 to Fuel a Self‐Amplifying CXCL8 Loop That Drives Perineural Invasion and Metastasis in Gastric Cancer

Advanced Science, EarlyView.
Neuron‐derived MIF binds VCAM1 on gastric cancer cells and activates ERK/STAT3 signaling, leading to CXCL8 transcription and secretion. Tumor‐derived CXCL8 subsequently stimulates neuronal CXCR2 to enhance MIF production, establishing a self‐amplifying MIF–VCAM1–CXCL8 positive‐feedback loop that promotes perineural invasion, tumor progression, and ...
Xunjun Li, Zhongya Zhai, Haiyi Yu, Renjie Qiu, Fengyu Li, Luxi Xiao, Boxi Huang, Huiying Liu, Jiayong He, Bowen Cai, Jiawen Chen, Jiang Yu, Guoxin Li, Tao Chen   +13 more
wiley   +1 more source

Correction: Colonic medullary carcinoma: an exceedingly rare type of colorectal malignancy: a case report and review of the literature

Journal of Medical Case Reports, 2023
Fajer Al‑Ishaq, Mahmood Al‑Dhaheri, Ali Toffaha, Salwa Awad, Syed Rizvi, Mohamed AbuNada, Mohamed Kurer   +6 more
doaj   +1 more source

Mapping the landscape of locally advanced colon cancer research: a 30-year bibliometric perspective

Discover Oncology
Our study aimed to perform a comprehensive bibliometric analysis to investigate the evolution of research in locally advanced colon cancer (LACC) over the past 30 years. This study examined 206 articles from the Science Citation Index Expanded within the
Yanwu Sun, Zhiping Chen, Zihan Tang, Zhenyu Xu, Hongfeng Pan, Pan Chi, Ying Huang   +6 more
doaj   +1 more source

Laparoscopic Colorectal Surgery [PDF]

Gastroenterology, 2000
openaire   +2 more sources

An Anterior Cingulate Cortex‐Anterior Insular Cortex Glutamatergic Circuit Gates Stress‐Induced Visceral Hypersensitivity and Anxiety via Ionotropic Glutamate Receptors Trafficking

Advanced Science, EarlyView.
This study identifies an anterior cingulate cortex (ACC) to anterior insular cortex (AIC) glutamatergic (Glu) circuit that gates stress induced visceral hypersensitivity and anxiety. Circuit activation induces both phenotypes, whereas inhibition relieves them.
Junwen Wang, Guangbing Duan, Huihui Sun, Zhiyu Dong, Qiwei Wang, Xiaowei Li, Ying Chen, Shuchang Xu, Ying Huang   +8 more
wiley   +1 more source

Single‐Cell Profiling Identifies SLC2A5‐Mediated Fructose Metabolism as a Vulnerability in Primary CNS Lymphoma

Advanced Science, EarlyView.
Glucose deprivation in the primary CNS lymphoma (PCNSL) tumor microenvironment drives SLC2A5 (encoding GLUT5)‐dependent fructose metabolism in tumor cells, while hypoxia induces HIF‐mediated SLC2A5 expression in tumor‐supportive macrophages, revealing SLC2A5‐driven fructose utilization as a shared and targetable metabolic vulnerability across malignant
Qiaoli Wu, Qianru Zhang, Wenqiang Yan, Lu Sun, Yiran Cui, Bolin Liu, Guoqing Han, Feng Zhang, Ke Pu, Mingchao Zhang, Xiaobing Zhang, Qingguo Li, Gang An, Yuxuan Liu   +13 more
wiley   +1 more source

Low rate of rescue epidural analgesia after open colorectal surgery with intrathecal morphine : a retrospective cohort study [PDF]

PurposeThe use of intrathecal morphine in open colorectal surgery has been limited despite being a promising analgesic alternative used in other types of open abdominal surgery.
Engdahl, Malin,, Östberg, Erland,, Engdahl, Malin, Chabok, Abbas,, de Brun, Sebastian,, de Brun, Sebastian, Chabok, Abbas, Östberg, Erland   +7 more
core   +1 more source

Proficient surgeons enhance conversion rates and sphincter preservation in robotic rectal cancer surgery with comparable long-term outcomes: a comparative study with laparoscopy in a large-volume center in China

BMC Cancer
Background Despite theoretical advantages, skepticism persists about robotic rectal cancer surgery due to the lack of evidence of benefit. This study aims to compare oncological and functional results of robotic-assisted surgery to laparoscopy, focusing ...
Xiaojie Wang, Yangyang Wang, Zhifen Chen, Zhifang Zheng, Shenghui Huang, Yanwu Sun, Ying Huang, Pan Chi   +7 more
doaj   +1 more source

Targeting the ATX‐LPA Axis Overcomes TKI Resistance and Immunosuppression in Renal Cell Carcinoma via Dual Inhibition of AKT/mTOR and TBK1/IRF3 Pathways

Advanced Science, EarlyView.
ABSTRACT Background Therapeutic resistance limits durable survival in advanced/metastatic renal cell carcinoma (RCC) treated with first‐line tyrosine kinase inhibitor (TKI) plus immune checkpoint inhibitor (ICI). We sought to define key resistance drivers and actionable targets.
Jinchen Luo, Hansen Lin, Haoqian Feng, Lei Tan, Xi Liu, Yong Huang, Junjie Cen, Jiajie Chen, Xinwei Zhou, Mingjie Lin, Wuyuan Liao, Zheyu Ai, Minyu Chen, Yinghan Wang, Wei Chen, Junhang Luo, Yanping Liang   +16 more
wiley   +1 more source