Results 131 to 140 of about 272,839 (312)

The Pathophysiological effects of adjuvant preoperative chemotherapy and/or radiotherapy on patients with advanced rectal cancer [PDF]

, 2013
Introduction The modern treatment of colorectal cancer consists of surgery, with or without adjuvant pre-operative radiotherapy, chemotherapy or chemoradiotherapy (APT) for selected cases. In the United Kingdom, therapy may be given prior to surgery in
Rahmani, Samir
core  

Intracorporeal Anastomosis for Robotic-assisted Right Hemicolectomy Using an Umbilical Assistant Port

Journal of the Anus, Rectum and Colon
There is ongoing debate on the respective merits of extracorporeal and intracorporeal anastomoses in patients undergoing minimally invasive surgery for right-sided colon cancer. Herein, we report the benefits of intracorporeal anastomosis for right-sided
Yusuke Kitagawa, Hisanori Miki, Takumi Yamamoto, Hiroki Uehara, Shoichiro I, Norikazu Yamada, Yuto Igarashi, Toshinori Kobayashi, Yoshihiro Mori, Jun Watanabe, Yosuke Fukunaga   +10 more
doaj  

Targeting KDM3B Elicits Anti‐tumor Immunity by Alleviating SHP1–mediated STING Suppression in Triple–Negative Breast Cancer

Advanced Science, EarlyView.
P3FI–90 treatment targets KDM3B, reshapes the epigenetic landscape, and suppresses SHP1 expression, thereby activating STING–TBK1–IRF3–type I IFN signaling pathway. Consequently, CD8+ T cells are recruited to the tumor site and activated to produce IFN–γ and GZMB, leading to the killing of TNBC cells.
Xiaolong Wang, Wenhao Li, Yifei Wang, Ning Zhang, Bing Chen, Wenjing Zhao, Lijuan Wang, Dan Luo, Qifeng Yang   +8 more
wiley   +1 more source

CEBPG‐Mediated Palmitic Acid Adaptation of Cancer‐Associated Fibroblasts Drives Metastasis of Oral Squamous Cell Carcinoma

Advanced Science, EarlyView.
This study reveals a metabolic signaling axis in the OSCC microenvironment where palmitic acid (PA) drives the activation of CAFs. PA uptake triggers CEBPG‐dependent epigenetic remodeling to upregulate ERN1 and TMBIM6, thereby mitigating ER stress. This adaptive program sustains CAF survival and the pro‐metastatic phenotype, establishing this pathway ...
Yiling Duan, Yitong Li, Yufei Wu, Xiao Yang, Rui Li, Hui Zhao, Zhengjun Shang   +6 more
wiley   +1 more source

Antimicrobial prophylaxis in colorectal surgery: focus on ertapenem [PDF]

, 2009
Fausto de LallaLibero Docente of Infectious Diseases, University of Milano, Milano, ItalyAbstract: Despite improvement in infection control measures and surgical practice, surgical site infections (SSIs) remain a major cause of morbidity and mortality ...
Fausto de Lalla
core  

Colorectal Surgery as a Specialty [PDF]

Journal of the Royal Society of Medicine, 1996
openaire   +3 more sources

CCT2 Promotes Prostate Cancer Progression Through EIF3F‐Dependent Stabilization of FASN

Advanced Science, EarlyView.
ABSTRACT Prostate cancer (PCa) is increasingly recognized to be driven by dysregulated lipid metabolism. Although fatty acid synthase (FASN) is highly expressed in PCa, the mechanisms governing FASN protein stability and its functional integration into oncogenic lipid metabolism remain poorly defined.
Shun Xu, Yifan Zhang, Haolin Li, Shengyu Zhao, Xiaoran Dai, Qili Xu, Mintian Fei, Chun Li, Zhihui Zou, Baojun Wang, Li Zhang, Hui Wang, Ligang Zhang, Chaozhao Liang   +13 more
wiley   +1 more source

Circulating Amino Acid Network Remodeling Reveals Systemic Metabolic Reprogramming Predictive of Colorectal Cancer Recurrence and Metastasis

Advanced Science, EarlyView.
Blood‐based amino acid patterns measured by 19F NMR reveal hidden metabolic changes in colorectal cancer. By analyzing how these amino acids interact as a network, machine learning models identify patients at higher risk of recurrence and metastasis.
Ji‐Yeon Lee, Jumi Kim, Taehan Yoon, So Hyun Kwon, Su Chan Park, Dohyun Chun, Dohyeong Kim, Eun Jung Park, Hyunwoo Kim, Ji Min Lee   +9 more
wiley   +1 more source

Single‐Cell RNA Editing Identifies T Cell ADAR1 as a Key Regulator of Immune Exhaustion and Anti‐PD‐1 Resistance in Colorectal Cancer

Advanced Science, EarlyView.
Single‐cell RNA editing analysis identifies ADAR1 as a regulator of dysfunctional T cell states in colorectal cancer. Elevated ADAR1 activity promotes T cell exhaustion and impairs antitumor immunity partly through TGF‐β‐SMAD signaling, contributing to anti‐PD‐1 resistance and highlighting T cell ADAR1 as a potential therapeutic target and biomarker ...
Da Kang, Song‐Zuo Xie, Yong‐Zhou Luo, Xin‐Pei Deng, Xi‐Rong Tan, Ze‐Geng Chen, Ling‐Xing Zeng, Gong Chen, Pei‐Rong Ding, Zhi‐Zhong Pan, Rong‐Xin Zhang   +10 more
wiley   +1 more source

Predicting outcome following colorectal cancer surgery using Colorectal Biochemical and Haematological Outcome Model (Colorectal BHOM) [PDF]

, 2010
Tang, T., Prytherch, David, Justin, T., Walsh, S., Walsh, S. R., Farooq, N., Patterson, A.   +6 more
core   +1 more source