Results 111 to 120 of about 1,849,576 (300)

The effects of oxaliplatin-based adjuvant chemotherapy in high-risk stage II colon cancer with mismatch repair-deficient: a retrospective study

BMC Cancer
Background For high-risk stageIImismatch repair deficient (dMMR) colon cancers, the benefit of adjuvant chemotherapy remains debatable. The principal aim of this study was to evaluate the prognostic value of high-risk factors and the effect of ...
Leen Liao, Jinghua Tang, Zhigang Hong, Wu Jiang, Yuan Li, Lingheng Kong, Kai Han, Zhenlin Hou, Chenzhi Zhang, Chi Zhou, Linjie Zhang, Qiaoqi Sui, Binyi Xiao, Weijian Mei, Jiehai Yu, Wanjun Yang, Zhizhong Pan, Pei-Rong Ding   +17 more
doaj   +1 more source

Approach of Colorectal Surgeons to Lower Rectal Adenocarcinomas: Results from the Turkish Society of Colon and Rectal Surgery Database [PDF]

Aim: This study aimed to analyze surgical preferences and outcomes among patients with lower rectal tumors in Türkiye using data from the national Colorectal Cancer Database of the Turkish Society of Colon and Rectal Surgery (TSCRS).
Mehmet Ali Koç, Kaan Sünter, Turkish Colorectal Cancer Database Study Group, Erman Aytaç   +3 more
core   +1 more source

CALB2 is a Mechanoresistance Gene in Metastatic Prostate Cancer

Advanced Science, EarlyView.
Prostate cancer cell lines of differing origins were cultured over many passages while being subjected to semi‐lethal levels of fluid shear stress, representing the harsh mechanical environment these cells are subjected to in the circulation during the process of distant metastasis.
Abigail R. Fabiano, Allen C. Luo, Paul Taufalele, Jenna A. Dombroski, Ehsan Aalaei, Schyler J. Rowland, Melissa S. Cantú, Alexandria T. Carter, Samantha V. Knoblauch, Cynthia A. Reinhart‐King, Michael R. King   +10 more
wiley   +1 more source

Risk and Management of Bowel Obstruction in Colorectal Cancer Patients Undergoing Immunotherapy: A Cross-Sectional Multicenter Study

ImmunoTargets and Therapy
Zhi-Gang Hong,1,2,* Binyi Xiao,1,2,* Muxu Zheng,1,2,* Wanjun Yang,1,2,* Liangjun Zhu,3 Guodong Liang,4 Yuhao Luo,5 Jinghua Tang,1,2 Weijian Mei,1,2 Jie-Hai Yu,1,2 Zhenlin Hou,1,2 Xiaojun Wu,1,2 Peirong Ding,1,2 Wu Jiang1,2
Hong ZG, Xiao B, Zheng M, Yang W, Zhu L, Liang G, Luo Y, Tang J, Mei W, Yu JH, Hou Z, Wu X, Ding P, Jiang W   +13 more
doaj  

Cell‐Selective Delivery of RIBOTACs via an Anti‐EGFR Nanobody for Pancreatic Cancer Treatment

Advanced Science, EarlyView.
This study introduces an innovative strategy for the tumor‐selective catalytic degradation of oncogenic non‐coding RNA by interfacing a ribonuclease‐recruiting small molecule (RIBOTAC) with an EGFR‐targeting nanobody via a CTSB (Cathepsin B)‐responsive linker.
Tianli Luo, Yijuan Wang, Dengwang Chen, Yinghan Zhang, Yi Shuai, Hualiang Yao, Tao Jiang, Hang Jiang, Ming Zhong, Xiangeng Wang, Ziwei Wang, Chenchen Xu, Ajay Goel, Hoi Tang MA, Feng Gao, Xin Wang   +15 more
wiley   +1 more source

Preoperative Prognostic Nutritional Index Predicts Postoperative Outcomes in Colorectal Cancer: A Propensity Score-Matched Cohort Study

Cancer Management and Research
Chew-Teng Kor,1– 3 Tsung-Jung Tsai,4 Tsung Chuang,4 Jui-Shen Chang,4 Wei-Huan Chen,4 Chang-Wei Chen,4 Yen-Hang Wu,4 Yu-Shih Liu,4 Xuan-Yuan Huang,4 Yu-Yao Chang4– 6 1Graduate Institute of Clinical Medicine, College of Medicine, National Chung Hsing ...
Kor CT, Tsai TJ, Chuang T, Chang JS, Chen WH, Chen CW, Wu YH, Liu YS, Huang XY, Chang YY   +9 more
doaj  

Microprotein MP104 Promotes Malignant Progression of Colorectal Cancer Through Regulating Protein Translation

Advanced Science, EarlyView.
A previously unrecognized microprotein, MP104, encoded by ZEB1‐AS1, emerges as a critical driver of colorectal cancer progression. MP104 links ubiquitin‐mediated protein degradation with translational reprogramming via the UBE2O–AMPKα2–mTOR–EIF4B axis, revealing an unrecognized layer of oncogenic regulation.
Fang Chen, Miao Wang, Hongmei Yong, Jin Ding, Shiping Xu, Qirui Ge, Yan Wang, Lei Zhang, Qianqian Xiao, Benli Li, Li Lin, Sufang Chu, Qianqing Wang, Jin Bai, Pingfu Hou   +14 more
wiley   +1 more source

WDR72 Promotes Neuroblastoma Stemness and Progression by Sequestering TRIM31‐Mediated Degradation of CBX8

Advanced Science, EarlyView.
This study unveiled that METTL14 mediates m6A modification of WDR72 mRNA to stabilize and enhance WDR72 expression, which disrupts TRIM31‐mediated ubiquitination of CBX8 protein and retards its degradation, finally the elevated CBX8 contributes to tumor stemness.
Huijuan Zeng, Zijie Ye, Manna Zheng, Jing Pan, Tianbao Tan, Jiliang Yang, Jiahao Li, Zhang Zhao, Tianzhu Long, Liyu Zhang, Gautam Sethi, Tianyou Yang, Chao Hu, Yan Zou   +13 more
wiley   +1 more source

Adherence to the enhanced recovery after surgery protocol and outcomes after colorectal cancer surgery.

, 2011
Objectives: To study the impact of different adherence levels to the enhanced recovery after surgery (ERAS) protocol and the effect of various ERAS elements on outcomes following major surgery.
Hausel, J, Soop, Mattias, Thorell, A, Nygren, J, Gustafsson, UO, Ljungqvist, O, Enhanced Recovery After Surgery Study Group   +6 more
core   +1 more source

O‐GlcNAcylation Regulation of SNAP29‐Dependent Autophagy Activation Dictates Chemoresistance in Gastric Cancer

Advanced Science, EarlyView.
Model illustrating the proposed mechanism by which chemotherapy‐induced downregulation of OGT disrupts SNAP29 O‐GlcNAcylation, promoting STX17‐SNAP29‐VAMP8 SNARE complex assembly and protective autophagy, leading to chemoresistance, which in turn establishes a feedforward loop to perpetuate drug tolerance.
Liang Tang, Shaoji Zhao, Ziling Shao, Tao Luo, Baifu Peng, Yifan Liu, Jinning Ye, Jianjun Peng, Kaiyu Sun, Jianbo Xu   +9 more
wiley   +1 more source