Results 91 to 100 of about 272,839 (312)

Mitigating Cancer Therapy–Related Cognitive Impairment by Targeted Activation of Undruggable Phosphatase

Advanced Science, EarlyView.
An RVG‑engineered exosomal saRNA delivery system (RVG‑EVs‑saPtpro) effectively targets and activates hippocampal PTPRO, functioning as a “molecular brake” to alleviate cancer therapy‑related cognitive impairment (CTRCI) by enhancing neuronal survival, neurogenesis, and synaptic plasticity.
Zhimeng Yao, Yuhua Meng, Huanyi Li, Yinhui Jiang, Xiaona Lin, Mengyuan Hu, Qing Liu, Xiaofu Qiu, Hongzheng Ren, Yunlong Pan, Bin Pan, Zexiong Guo, Shuyao Zhang, Dianzheng Zhang, Li Yang, Shegan Gao, Weijing Deng, Jianfan Chen, Hao Zhang   +18 more
wiley   +1 more source

Approach of Colorectal Surgeons to Lower Rectal Adenocarcinomas: Results from the Turkish Society of Colon and Rectal Surgery Database [PDF]

Aim: This study aimed to analyze surgical preferences and outcomes among patients with lower rectal tumors in Türkiye using data from the national Colorectal Cancer Database of the Turkish Society of Colon and Rectal Surgery (TSCRS).
Mehmet Ali Koç, Kaan Sünter, Turkish Colorectal Cancer Database Study Group, Erman Aytaç   +3 more
core   +1 more source

Impact of physical activity and diet on colorectal cancer survivors’ quality of life: a systematic review

World Journal of Surgical Oncology, 2019
Background Post-treatment management is essential for improving the health and quality of life of colorectal cancer (CRC) survivors. The number of cancer survivors is continually increasing, which is causing a corresponding growth in the need for ...
Ameera Balhareth, Mohammed Yousef Aldossary, Deborah McNamara   +2 more
doaj   +1 more source

Colorectal Surgery [PDF]

Indian Journal of Surgery, 2015
It is a great privilege to write a review for a book on Colorectal Surgery edited by Dr. Prabin B. Thapa and Dr. Dhiresh K. Maharjan. The book provides comprehensive information about many aspects of colorectal surgery. It also includes the surgical anatomy and its relevance in total mesorectal excision (TME).
openaire   +1 more source

Genome‐Wide In Vivo RNAi Screening Identifies HOXD4 as a Tumor Metastasis Suppressor in Colorectal Cancer

Advanced Science, EarlyView.
Metastasis remains a major challenge in colorectal cancer. Using an in vivo shRNA screening system, this study identifies Homeobox D4 as a key metastasis suppressor. Reduced Homeobox D4 expression is associated with aggressive tumor features. Functional and mechanistic analyses show that it inhibits epithelial‐mesenchymal transition by repressing ...
Zhi‐hua Ye, Wen‐jing Luo, Lu Li, Wen‐di Shuai, Ling Zhou, You‐fa Duan, Xue Chen, Jun‐kai Zhang, Wenlin Huang, Ran‐yi Liu   +9 more
wiley   +1 more source

Perceived information after surgery for colorectal cancer - an explorative study [PDF]

, 2012
Aim: With fast track surgery and shorter hospital stay, discharge from hospital after cancer surgery is becoming more challenging for the individual patient.
Klefsgård, Rosemarie, Johansson, Jan,, Andersson, Edith, Lund University., Lithner, Maria,, Palmquist, Ingrid,, Jakobsson, Ulf,   +6 more
core   +1 more source

Small Extracellular Vesicles‐Derived Circ6718 Unlocks Stromal Remodeling and Serves as a Biomarker in Gastric Cancer

Advanced Science, EarlyView.
sEVs‐circ6718 serves as a promising serum biomarker for gastric cancer early diagnosis and prognosis, promoting malignant transformation in gastric cancer cells and GC‑MSC differentiation into CAFs. sEVs‑circ6718 holds potential as a biomarker for the early diagnosis and prognostic assessment of gastric cancer.
Fan Zhang, Xueyan Zang, Dongli Wang, Rong Li, Hui Qian, Wenrong Xu, Jiajia Jiang, Yongmin Yan   +7 more
wiley   +1 more source

Ileus Management International (IMAGINE): protocol for a multicentre, observational study of ileus after colorectal surgery [PDF]

, 2018
Aim: The management of postoperative ileus following colorectal surgery remains controversial. It is the commonest complication after elective colorectal resection and is associated with an increased incidence of postoperative adverse events.
Goodson, R, El Kasmy, Y, Gecim, IE, Paramasivam, R, Venara, A, Poskus, T, Baki, BE, Glasbey, JCD, Fomin, I, Lorenzon, L, Aktas, MK, Pinkney, TD, Bautista, O Anabitarte, Bath, M, Otto, A, Yasin, I, van Elst, TR, Larsen, H, Sgro, A, Bemelman, WA, Bhangu, A, Mills, E, Schaeff, V, Arthur, T, Yuksek, B, Nepogodiev, D, Borakati, A, Carneiro, C, Frey, P-E, Podda, M, Hubner, M, Fagan, P, ten Doesschate, SFH, Ozolins, A, Hodson, J, Nors, J, Pellino, G, Martensen, A, Zaffaroni, G, Espin-Basany, E, Vasko, P, Sivins, A, Joao, AA, Sen, AY, Farina, V, Golding, D, Ravn, S, Chu, MJJ, Fitzgerald, J Edward, Soares, AS, Chan, E, Pata, F, van Dalen, ASHM, Clerc, D, Orhalmi, J, Mihaljevic, AL, Thakral, N, Ho, D, Bissett, IP, Raedeker, LB, Chapman, SJ, Khatri, C, Pasquali, S, Blanco-Colino, R, Zabrak, R, Perez-Ajates, S, Simioni, A, Kuiper, SZ, Ozkan, BB, Morgan, S, Schachtel, M, Jakubauskas, M, Gavagna, L, Wells, CI, Khaw, R, Friedrich, M, Kamarajah, S, Vaughan-Shaw, PG, Nabi, H, McLean, K   +79 more
core   +1 more source

Case report: Coexistence of rectal signet ring cell carcinoma with neuroendocrine components

BMC Geriatrics
Background Signet ring cell carcinoma is a rare histological type among the various forms of colorectal cancers. Even rare is when it coexisted with neuroendocrine components in one tumor.
Ling Xu, Zhefeng He, Chao Fu, Yiyang Wu, Anwei Wu, Guojiang Tian, Jianfei Huang, Xibo Liu, Qi Wang   +8 more
doaj   +1 more source

The Development and Pilot Clinical Study of CD147 Targeted Antagonistic Peptide Probe for Tumor Imaging

Advanced Science, EarlyView.
This study establishes [68Ga]Ga‐DOTA‐AP9 as a first‐in‐human CD147‐targeted PET tracer with favorable safety and specific tumor uptake. Tracer accumulation correlates with CD147 expression in patients, enabling noninvasive quantification of CD147‐positive malignancies.
Xiaokun Ma, Rui Guo, Dongfeng Niu, Yufei Song, Zhenyao Zhang, Xiangxi Meng, Lili Mao, Haifeng Huang, Hua Zhu, Zhi Yang, Teli Liu   +10 more
wiley   +1 more source