Results 131 to 140 of about 26,686 (294)

Functional Analysis of Ligand‐Gated Chloride Channels in a Cnidarian Sheds Light on the Evolution of Inhibitory Signaling

Advanced Science, EarlyView.
We uncover a large variety of putative inhibitory ligand‐gated ion channels (LGICs) in the phylum Cnidaria, the sister group to all bilaterian animals. Phylogenetic analysis suggests a complex evolutionary history of inhibitory LGICs with diverse neurotransmitter ligands.
Abhilasha Ojha, Linda Kloss, Juan D. Montenegro, Simone Albani, Audrey Ortega‐Ramírez, Mihaela Raycheva, Sylvia Joussen, Sabrina Kaul, Michèle Bachmann, Lisa Huf, Günther Schmalzing, Alison G. Cole, Ulrich Technau, Stefan Gründer   +13 more
wiley   +1 more source

Colorimetric Sensors with Enhanced Sensitivity and Angle‐independence

Advanced Sensor Research
Sensors that can be portable and easy to read out are highly attractive for point‐of‐care. However, such sensors often suffer from low sensitivity for real‐life applications.
Hiu Ning Tiffany Chui, Shu Yang
doaj   +1 more source

Colorimetric and SERS-Based Multimode Detection Platform for Cu(II) Ions Using Peptide–Gold Nanoparticles

Colorants
Excessive copper ions in the human body can cause a variety of diseases, such as gastrointestinal disorders, cirrhosis, and Alzheimer’s disease. Techniques like Inductively Coupled Plasma–Mass Spectroscopy and Atomic Absorption Spectroscopy are available
Panangattukara Prabhakaran Praveen Kumar
doaj   +1 more source

Colorimetric Sensing of DNA via Catalytic Release of Gold Nanoparticles

, 2021
Gold nanoparticles immobilized on a polymer microbead template via a catalytic DNA network can be functionally used as a colorimetric DNA sensor. Previous sensors have been designed that exploit the colorimetric properties of gold nanoparticles when ...
Lee, Jeunghoon, (Mentor), Kuskie, Dara, Knudson, Luke, Paulus, Crystal   +3 more
core  

PRMT1‐Mediated LDHA Methylation Drives STAT3 Lactylation to Orchestrate Intestinal Inflammation and Tumorigenesis

Advanced Science, EarlyView.
This study identifies an immunometabolic axis wherein SAM‐driven PRMT1 methylates LDHA, enhancing its activity. The resultant lactate induces STAT3 K709 lactylation, which stabilizes an active conformation to promote STAT3 phosphorylation and IL‐10 expression.
Hui Wang, Mengyu Zhang, Weipeng Gong, Jiaxuan Wu, Junping Zhang, Wenxiu Zhang, Yue Liu, Kui Wang, Canhua Huang, Jun Zhou, Sijin Wu, Yan Li, Tianliang Li   +12 more
wiley   +1 more source

Enhanced Glycolysis‐Driven Histone H3K18 Lactylation Regulates Epileptogenesis by Modulating the E3 Ubiquitin Ligase COP1

Advanced Science, EarlyView.
Neuronal PKM2‐driven glycolysis generates excess lactate that triggers histone H3K18 lactylation (H3K18la), establishing a pathogenic metabolic‐epigenetic axis in epilepsy. Elevated H3K18la enriches the Cop1 promoter, transcriptionally upregulating the E3 ubiquitin ligase COP1, which subsequently drives proteasomal degradation of GABAARβ2 and impairs ...
Yuan Meng, Yanlin Guo, Liumi Jiang, Jing Luo, Yan Liu, Ziwei Yuan, Pingyang Ke, Ran Duan, Fei Xiao   +8 more
wiley   +1 more source

Bimetallic Fe₃O₄@Co₃O₄/CN as a Nanozyme with Dual Enzyme-Mimic Activities for the Colorimetric Determination of Mercury(II)

Chemosensors
Colorimetric biosensor-based nanozymes have received considerable attention in various fields thanks to the advantages of the simple preparation, good stability, and regulable catalytic activity of nanozymes.
Yanyan Xing, Pingping He, Deyong Wang, Yuan Liang, Xing Gao, Xiaohong Hou   +5 more
doaj   +1 more source

Multi‐Enzyme Mimetic Molybdenum Nitride Nanozymes Reshape Subgingival Microenvironment for Synergistic Periodontitis Therapy via ROS Regulation and Microbiome Remodeling

Advanced Science, EarlyView.
ABSTRACT Periodontitis, a chronic inflammatory disease initiated and sustained by plaque microorganisms and host immune response, remains an intractable oral disease and a leading cause of tooth loss worldwide. Traditional mechanical debridement and adjunctive antibiotic or antiseptic therapy often shows limited efficacy due to the complex anatomical ...
Weiyu Zhang, Zhongwei Yang, Yunfan Zhang, Longwei Wang, Xiaoyu Zhang, Jiahui Mao, Yizhi Dai, Yifan Yuan, Mingge Wang, Xin Yang, Xin Yu, Jing Liu, Chunying Chen   +12 more
wiley   +1 more source

Smart Probes for Ultrasensitive and Highly Selective Sensing of Homocysteine over Cysteine Based on Multi-Cooperative Effects by Using Gold Nanoparticles

Molecules
Homocysteine (Hcy) is a biothiol that plays a vital role in many physiological processes and is involved in a variety of diseases. However, it is significantly difficult to discriminate Hcy from cysteine (Cys) due to their similar chemical structures ...
Manman Sun, Peihao Zhang, Zeze Xie, Pengcheng Zhang, Zhendong Li, Zhiguang Yang, Hongyu Chen   +6 more
doaj   +1 more source

Palladium nanoparticle colored cotton fabric as a highly efficient catalyst for colorimetric sensing of H2O2

, 2020
Palladium nanoparticle colored cotton fabric as a highly efficient catalyst for colorimetric sensing of ...
J Zhang (7490018), X Wang (1378959), Jingliang Li (13076322), J Wang (20900), J Zhou (2892584), Bin Tang (13061175), F Zou (13398627), C Xu (7775762)   +7 more
core