Results 111 to 120 of about 909,337 (236)

Gut Microbiota‐Isoallolithocholic Acid Crosstalk Promotes Calcium Oxalate Kidney Stone Formation via PARP1‐Mediated Parthanatos

Advanced Science, EarlyView.
ABSTRACT Bile acids have been implicated in calcium oxalate (CaOx) nephrolithiasis. Here, we employ multi‐omics approaches to identify isoallolithocholic acid (isoalloLCA) as the key bile acid elevated in the feces, serum, kidney, and urine of CaOx rats, confirmed by spatial metabolomics.
Zijian Zhou, Ruixi Yu, Xuan Zhou, Feng Shi, Zeyu Lin, Peng Gao, Lujia Wang, Ninghan Feng, Zhong Wu, Dawei Wang   +9 more
wiley   +1 more source

Colorimetric Sensors with Enhanced Sensitivity and Angle‐independence

Advanced Sensor Research
Sensors that can be portable and easy to read out are highly attractive for point‐of‐care. However, such sensors often suffer from low sensitivity for real‐life applications.
Hiu Ning Tiffany Chui, Shu Yang
doaj   +1 more source

New Cation Sensors Based on Eugenol-Derived Azo Dyes

Molecules
Eugenol-based azo dyes illustrate how bio-sourced compounds like eugenol can be transformed through synthetic processes into functional and colorful compounds.
José R. A. Coelho, Ana Rita F. Pacheco, Diogo C. Domingues, Ana Rita O. Rodrigues, Akani A. Temitope, Paulo J. G. Coutinho, Maria José G. Fernandes, Elisabete M. S. Castanheira, M. Sameiro T. Gonçalves   +8 more
doaj   +1 more source

Serial Molecular‐Microstructural Multimodal Intravascular Imaging of Atherosclerotic Plaques in Mice

Advanced Science, EarlyView.
A novel longitudinal molecular and microstructural intravascular imaging approach is developed to study murine atherosclerosis. The technique combines a unique surgical model with a miniaturized multimodal device to detect macrophage activity and lipid simultaneously.
Jiawen Li, Joanne T. M. Tan, Lei Xiang, Jiandi Liu, Ayla Hoogendoorn, Victoria A. Nankivell, Lauren Sandeman, Richard Le, Rouyan Chen, Robert A. McLaughlin, Peter J. Psaltis, Johan W. Verjans, Christina A. Bursill   +12 more
wiley   +1 more source

Recent Advances in Aptamer-Based Point-of-Care Testing

Sensors
Aptamers refer to a class of oligonucleotide probes that have demonstrated remarkable capabilities beyond mere genetic coding, including the unique ability to recognize and selectively bind to specific molecular targets.
Senlin Luo, Xiaotian Zhang, Yuzhuo Zhang, Xiaofeng Qu, Qiru Sun, Tianhuan Peng, Quan Yuan   +6 more
doaj   +1 more source

p300‐Mediated H3K18 Lactylation Drives Radiation‐Induced Pulmonary Fibrosis via VIRMA‐Dependent m6A Modification of GATA3

Advanced Science, EarlyView.
Radiation triggers glycolytic reprogramming in alveolar epithelial type II cells, causing pathological lactate accumulation. This metabolic stress drives p300‐mediated H3K18 lactylation at the VIRMA promoter, activating transcription. Elevated VIRMA enriches m6A on GATA3 mRNA, which YTHDF1 stabilizes, ultimately driving epithelial–mesenchymal ...
Junxuan Yi, Mingwei Wang, Duo Yu, Mingqi Zhao, Xinyan Wang, Shiqi Li, Xiaowen Han, Wei Wei, Shunzi Jin   +8 more
wiley   +1 more source

An Effector TaCRVP From Tuta Absoluta Oral Secretion Impairs H2O2‐Mediated Plant Defense by Targeting Tomato SlCAT2

Advanced Science, EarlyView.
The Tuta absoluta salivary effector TaCRVP subverts tomato immunity by hijacking host catalase SlCAT2. Through a sophisticated dual mechanism, TaCRVP simultaneously promotes SlCAT2 tetramerization for activation and blocks its SlAdBiL‐mediated degradation for stabilization.
Jianquan Yan, Youdan Zhang, Zhujun Wang, Huatao Tang, Huiping Liu, Zi Chen, Shuai Liu, Jiayi Shi, Lu Peng, Youming Hou   +9 more
wiley   +1 more source

A route to new colorimetric pH sensors

, 2017
The detection of target molecules via luminescence changes of appropriate sensors is a powerful tool to determine the presence of analytes qualitatively and quantitatively.
Sebastian Wandtke, Wandtke, Sebastian, Dietmar Stalke, Stalke, Dietmar   +3 more
core   +1 more source

A Synthetic Platform for Antibody Junctional Diversification Beyond Natural Constraints

Advanced Science, EarlyView.
ARESEC is a synthetic platform that reconstructs functional V(D)J recombination in HEK293T cells. By introducing RSS elements and co‐expressing RAG1/2 and TdT across all three antibody CDRs, it enables programmable junctional diversification and direct generation of high‐affinity variants targeting PD‐1/PD‐L1, overcoming the evolutionary constraints of
Wang Liu, Jun Yang, Yuhang Zhang, Xiaoli Xue   +3 more
wiley   +1 more source

Reading Dye-Based Colorimetric Inks: Achieving Color Consistency Using Color QR Codes

Chemosensors
Color consistency when reading colorimetric sensors is a key factor for this technology. Here, we demonstrate how the usage of machine-readable patterns, like QR codes, can be used to solve the problem.
Ismael Benito-Altamirano, Laura Engel, Ferran Crugeira, Miriam Marchena, Jürgen Wöllenstein, Joan Daniel Prades, Cristian Fàbrega   +6 more
doaj   +1 more source