Results 131 to 140 of about 909,337 (236)

DLST Succinylation‐Mediated Mitochondrial Metabolic Remodeling and Cuproptosis Resistance Promote Malignant Progression of Lung Adenocarcinoma

Advanced Science, EarlyView.
The DLST K409 succinylation mediated by CPT1A promotes OXPHOS and redox homeostasis through regulating enzyme activity, thereby promoting the malignant progression of LUAD. Notably, the succinylation of DLST can enhance the cuproptosis resistance by inhibiting its lipoylation.
Xuanxuan Li, Peijun Zhou, Xingzhi Peng, Qixin Liu, Wenhui Zeng, Rui Wang, Liangfang Shen, Jinwu Peng, Qin Zhou, Lifang Yang   +9 more
wiley   +1 more source

Controlled Lattice Distortion and Lattice‐Strain‐Engineered CoCuIr Alloy toward Preferential Chlorine Tolerant Direct Seawater Electrolysis

Advanced Science, EarlyView.
A lattice‐strain‐engineered Co0.28Cu0.67Ir0.05 trimetallic alloy nanoparticle electrocatalyst is rationally designed for efficient alkaline seawater electrolysis. Larger Ir atoms in the CoCu lattice modulate the local coordination environment, generating compressive lattice strain and highly active catalytic sites.
Ankur Kumar, Abhinav Yadav, Saloni Latiyan, Palash J. Thakuria, Ankur K. Guha, Sasanka Deka   +5 more
wiley   +1 more source

A Metal‐Polyphenol Self‐Assembled Coated 3D Sponge With Mild Photothermal Antibacterial, Exudate‐Controlling, and Immunomodulatory Functions for Hemostasis and Chronic Wound Healing

Advanced Science, EarlyView.
A thrombin‐functionalized copper‐polydopamine nanofiber sponge integrates rapid hemostasis, mild photothermal antibacterial therapy, stimulus‐responsive Cu2+ release, chemodynamic oxidative stress, and macrophage immunomodulation. This multifunctional dressing suppresses infection, regulates inflammation, promotes angiogenesis and re‐epithelialization,
Ziwei Zhang, Feng Qin, Xiaomeng Zhang, Xueqin Shuang, Jiahua Zhou, Ming Cheng, Baicheng Lu, Mingyue Song, Yuntian Bai, Dianying Zhang, Ming Li, Yanhua Wang   +11 more
wiley   +1 more source

Interleukin‐1α Mediates Pancreatic Fibroblast Activation, Regulates Immune Cell Recruitment and Fibrosis in Acute and Chronic Pancreatitis

Advanced Science, EarlyView.
During pancreatitis, IL‐1α is released from necrotic acinar cells. In response to IL‐1α, pancreatic fibroblasts release chemokines and cytokines that regulate the recruitment of immune cells to the damaged organ. Furthermore, IL‐1α primes fibroblasts, resulting in increased tissue fibrosis during chronic pancreatitis.
Hala Mazloum, Shenja Buchholz, Hanna Schifter, Sabine Ameling, Leif Steil, Ben Lewin Becker, Elke Hammer, Georg Homuth, Uwe Völker, Barbara M. Bröker, Lukas Zierke, Frank Ulrich Weiss, Juliane Glaubitz, Matthias Sendler   +13 more
wiley   +1 more source

Functional–Taxonomic Scaling Resolves Conflicting Average Genome Size Estimates Across Environmental Gradients

Advanced Science, EarlyView.
Based on genome size‐functional breadth theory, we introduce and validate a framework that adjudicates conflicting average genome size (AGS) estimates by testing which estimate yields a gap between scaled functional diversity and scaled taxonomic diversity that is consistent with the expected positive association between genome size and gene functional
Huanhuan Zhu, Xiaoye Chen, Qiushi Li, Chenyu Sun, Haihua Xia, Yingxin Huang, Cong Wang, Peilin Chen, Cheng Gao   +8 more
wiley   +1 more source

Mechanophore‐Based Multichannel Colorimetric Force Sensors: Ultrasound‐Driven Stress and Strain Quantification

Advanced Science, EarlyView.
ABSTRACT Mechanophores with mechanochromic properties have attracted significant attention as force‐responsive materials for structural sensing. However, their applications remain mainly limited to qualitative force visualization, as direct and quantitative extraction of mechanical parameters such as stress and strain from mechanochromic responses has ...
Seungo Baek, Jeong Hoon Rhee, Skylar K. Osler, Minsoo P. Kim, Shyuan Cheng, Leonardo P. Chamorro, Hyunhyub Ko, Maxwell J. Robb, Gun Kim   +8 more
wiley   +1 more source

Programmable Guest‐Induced 5‐Phase‐Transition Topological Reconstructions of Cobalt Formate Metal–Organic Frameworks

Advanced Science, EarlyView.
A reversible five‐phase topological cycle is achieved in a minimalist cobalt formate metal–organic framework. The amorphous phase functions as a programmable reactive hub, selectively reconstructing into four distinct crystalline architectures through cationic templates, humidity, or CO2.
Zhiyu Tao, Jingjian Li, Jing Ling, Tianxiang Chen, Wing‐Yiu Yu, Cong Lin, Tsz Woon Benedict Lo   +6 more
wiley   +1 more source

Ultrasound‐Activated Nanoinhibitors Blocking the Chemo‐Immune Checkpoint to Overcome Chemotherapy‐Induced Immune Resistance

Advanced Science, EarlyView.
A sono‐responsive chemo‐immune checkpoint nanoinhibitor (Sono‐TT8) co‐delivering TPZ chemotherapy and siXkr8 simultaneously kills tumor cells and blocks PS externalization, reversing chemotherapy‐induced immunosuppression and enhancing antitumor immunity. ABSTRACT Breast cancer features an immunosuppressive tumor microenvironment following chemotherapy
Yunfan Liu, Chier Du, Leilei Zhu, Hongjin An, Shengzhe Hou, Yi Lan, Xuemei Tang, Min Xu, Peng Luo, Hua Teng, Hao Yang, Xun Guo, Jianli Ren, Zhiyi Zhou   +13 more
wiley   +1 more source

Research progress of dual-emission colorimetric luminescent oxygen sensors

, 2011
通讯作者, E-mail: xichen@xmu.edu.cn[中文文摘]简单、快速进行氧检测的方法一直是人们研究的热点.在众多检测氧的方法中,发光比色法由于简单和可直读的特性受到人们的广泛关注.本文将简单地介绍近几年国内外基于双原色发光比色氧传感器的研究进展,并展望其研究前景.[英文文摘]Simple and rapid detection of oxygen is one of the most central issues in oxygen sensing.Due to the ...
周廷尧, 王旭东, 陈曦, 刘夕玮
core  

Restoring Endothelial Mitochondrial Homeostasis With a Bioactive Nanoshield Promotes Vascular Regeneration on Cardiovascular Implants

Advanced Science, EarlyView.
A bioactive poly(citrate‐polyglycol‐procyanidin) (PCGP) nanoshield is developed for cardiovascular implants to restore endothelial mitochondrial homeostasis following vascular injury. By preserving mitochondrial integrity, re‐establishing metabolic balance, and activating PI3K/Akt/eNOS‐NO signaling, the PCGP interface promotes functional endothelial ...
Xiyu Liu, Wen Zhang, Lunxin Liu, Lan Gui, Yumei Qin, Xiaohui Yang, Longjian Zhang, Chaohua Wang, Jinpeng Hu, Gaoyang Guo, Qing Jiang, Jin Wang, Li Yang, Bo Zhang, Yunbing Wang   +14 more
wiley   +1 more source