Results 91 to 100 of about 613,537 (264)

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source

A systematic survey of the online trade in elephant ivory in Singapore before and after a domestic trade ban

Oryx
The illegal online trade in wildlife has increased significantly over the last 2 decades. Applying a systematic survey approach, we examined the online trade in elephant ivory before and after the implementation of a domestic trade ban in Singapore, to ...
Hazelina H.T. Yeo, Sean J.W. Ng, Janelle S.R. Lee, Malcolm C.K. Soh, Anna M.S. Wong, Adrian H.B. Loo, Kenneth B.H. Er   +6 more
doaj   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

Effect of processing conditions on cyanide content and colour of cassava flours from West Africa [PDF]

, 2009
The evolution of cyanide content and colour were monitored during the processing of lafu, traditional flour and improved flour from five cassava cultivars from Benin. In addition, the total phenol, polyphenoloxidase (PPO), peroxydase (POD) and linamarase
Akissoé, Noël H., Coffi Nago, Mathurin, Hongbete, Franck, Mestres, Christian   +3 more
core  

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source

Differential regulation of ZFAS1 splice variants by endoplasmic reticulum stress in hepatocyte cell lines

FEBS Open Bio, EarlyView.
ZFAS1 is a lncRNA promoting cell proliferation and migration, exhibiting high expression in various cancers. It is conserved, widely expressed, and produces multiple splice variants with unclear roles. We identified several splice variants in hepatocyte models, and found that inhibiting or suppressing regulators of the unfolded protein response (PERK ...
Sébastien Soubeyrand, Paulina Lau, Ruth McPherson   +2 more
wiley   +1 more source

Lipid Peroxidation in Muscle Foods: Impact on Quality, Safety and Human Health

Foods
The issue of lipid changes in muscle foods under the action of atmospheric oxygen has captured the attention of researchers for over a century. Lipid oxidative processes initiate during the slaughtering of animals and persist throughout subsequent ...
Stefan G. Dragoev
doaj   +1 more source

Colour Deconfinement and Quarkonium Binding

, 2005
At high temperatures, strongly interacting matter becomes a plasma of deconfined quarks and gluons. In statistical QCD, deconfinement and the properties of the resulting quark-gluon plasma can be investigated by studying the in-medium behaviour of heavy ...
Adler S S (PHENIX Collaboration), Adler S S (PHENIX Collaboration), Affolder T (CDF Collaboration), Alberico W, Arnaldi R (NA60 Collaboration), Becattini F, Borges G (NA50 Collaboration), Braaten E, Digal S Karsch F Satz H, Ejiri S Karsch F Redlich K, Fodor Z, Gavai R V Gupta S, Goloviznin V, Gunji T (PHENIX Collaboration), Hagedorn R, Hagedorn R, Helmut Satz, Iida H, Kaczmarek O, Kaczmarek O Zantow F, Karsch F, Katz S, Kharzeev D Karsch F Satz H, Landau L D, Mangano M, Morrin R, Peikert A, Pereira da Costa H (PHENIX Collaboration), Petreczky P, Sitta M (NA50 Collaboration), Wong C-Y, Wong C-Y   +31 more
core   +1 more source

Dapagliflozin prevents methylglyoxal‐induced retinal cell death in ARPE‐19 cells

FEBS Open Bio, EarlyView.
Diabetic macular oedema is a diabetes complication of the eye, which may lead to permanent blindness. ARPE‐19 are human retinal cells used to study retinal diseases and potential therapeutics. Methylglyoxal is a compound increased in uncontrolled diabetes due to elevated blood glucose.
Naina Trivedi, Zainab Quraishi, Shima Khezri Azizi Far, Madaleine Ward, Aidan Conway, Reem Abdulredha, Eman Mshari, Yousif A. Shamsaldeen   +7 more
wiley   +1 more source