Results 51 to 60 of about 815,609 (326)

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Economic dispatch of generation load aggregators based on two-stage robust optimization

Frontiers in Energy Research, 2023
Introduction: In recent years, with the rapid development of renewable energy generation, the stability of the power grid has been greatly reduced. In response to this problem, integrating the user side transferable load into the power market has become ...
Haonan Zhang, Youwen Tian, Yi Zhao, Qingyu Liu, Nannan Zhang   +4 more
doaj   +1 more source

A note on "A LP-based heuristic for a time-constrained routing problem" [PDF]

, 2010
Avella et al. (2006) [Avella, P., D'Auria, B., Salerno, S. (2006). A LP-based heuristic for a time-constrained routing problem. European Journal of Operational Research 173:120-124] investigate a time-constrained routing (TCR) problem.
Birbil, S. Ilker, Birbil, Ş. İlker, Bulbul, Kerem, Bülbül, Kerem, Muter, İbrahim, Muter, Ibrahim, Sahin, Guvenc, Şahin, Güvenç   +7 more
core  

Designing an efficient test pattern generator using input reduction with linear operations [PDF]

, 2018
Advances in fabrication technology have resulted in more complicated systems, being used in ever increasing numbers of applications. The large increase in transistor counts versus the number of pins on the chip has made VLSI testing much harder than ever
Lee, Kangjoo
core   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

A Column-Generation-Based Exact Algorithm to Solve the Full-Truckload Vehicle-Routing Problem

Mathematics
This study addresses a specialized variant of the full-truckload delivery problem inspired by a Turkish logistics firm that operates in the liquid transportation sector.
Toygar Emre, Rizvan Erol
doaj   +1 more source

Crucial parameters for precise copy number variation detection in formalin‐fixed paraffin‐embedded solid cancer samples

Molecular Oncology, EarlyView.
This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris, Vasiliki Siozopoulou, Léon C van Kempen, Anne Sieben, Ella Roelant, Stig Hellemans, Elyne Backx, Laure Sorber, Koen De Winne, Senada Koljenović, Karen Zwaenepoel   +10 more
wiley   +1 more source

A Three-Stage Optimization Method for Assembly Line Balancing Problem

IEEE Access, 2020
Considering the characteristics of multimodels production pattern on assembly line, the assembly line balancing problem which is non-deterministic polynomial hard becomes more challenging to complete. In this article, we propose a reformulation of simple
Qidong Yin, Xiaochuan Luo
doaj   +1 more source

Heuristic column generation algorithm for aircraft dynamic scheduling

TELKOMNIKA Indonesian Journal of Electrical Engineering, 2013
Aircraft dynamic scheduling made a rational organization of surplus aircrafts to generate the optimized aircraft dispatch solution. The approach improved the operation efficiency and aviation enterprise benefits. To describe the complex relationship in aircraft dispatch, according to the characteristics of the airlines operation network, the research ...
Fang Jie, Xia Hong-shan
openaire   +1 more source

An algorithm for the microaggregation problem using column generation

Computers & Operations Research, 2022
The field of statistical disclosure control aims to reduce the risk of re-identifying an individual from disseminated data, a major concern among national statistical agencies. Operations Research (OR) techniques have been widely used in the past for protecting tabular data, but not microdata (i.e., files of individuals and attributes).
Jordi Castro, Claudio Gentile, Enric Spagnolo-Arrizabalaga   +2 more
openaire   +3 more sources