Results 61 to 70 of about 815,609 (326)
Tumor mutational burden as a determinant of metastatic dissemination patterns
Molecular Oncology, EarlyView.This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal +4 more
wiley +1 more source
Coordinated planning of multi-energy systems considering demand side response
Energy Reports, 2020 Integrated multi-energy systems, due to their flexibility and complementary characteristics, are considered an important energy system structure for accommodating high renewable penetration, and thus have attracted great attention of global research ...
Jinpeng Wang +3 more
doaj +1 more source
Molecular Oncology, EarlyView.To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley +1 more source
Journal of Advanced Transportation, 2018 This paper aims to optimize high-speed railroad timetables for a corridor. We propose an integer programming model using a time-space network-based approach to consider passenger service demands, train scheduling, and station service demands ...
Jin Wang +4 more
doaj +1 more source
User Assignment in C-RAN Systems: Algorithms and Bounds
, 2018 In this work, we investigate the problem of mitigating interference between so called antenna domains of a cloud radio access network (C-RAN). In contrast to previous work, we turn to an approach utilizing primarily the optimal assignment of users to ...
Ghauch, Hadi +5 more
core +3 more sources
Molecular Oncology, EarlyView.This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source
Annealing-Assisted Column Generation for Inequality-Constrained Combinatorial Optimization Problems
IEEE AccessIsing machines are expected to solve combinatorial optimization problems faster than the existing integer programming solvers. These problems, particularly those encountered in practical situations, typically involve inequality constraints.
Hiroshi Kanai +3 more
doaj +1 more source
International Journal of Applied Earth Observations and Geoinformation, 2022 Satellite remote sensing is an efficient and economical technique for studying coastal bottoms in clear and shallow waters. Accordingly, the main objective of this study is the generation of benthic maps using high spatial resolution multispectral images
A. Mederos-Barrera +3 more
doaj +1 more source