Results 41 to 50 of about 636,696 (218)
Reinforcement mechanism of vibro-stone columns with additional wicks and numerical analysis
工程科学学报, 2015 An energy model of excess pore pressure generation under vibration loading was adopted to simulate the installation process of composite vibro-stone columns.
LIU Yang, YAN Hong-xiang, WANG Cheng-lin
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Bulletin of the Polytechnic Institute of Jassy: Constructions, Architechture Section, 2022 The vertical structural components of RC frame buildings are the fundamental elements that ensure lateral stability of entire system under exceptional seismic loading situations.
Sococol Ion, Mihai Petru, Shams Ali
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Buildings, 2023 The effect of (1) initial imperfections and (2) material degradation of reinforced concrete columns on their safety in emergency situations was investigated. The research was limited to low- and medium-flexibility columns.
Anatoly Victorovich Alekseytsev +1 more
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Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
eLifeChondrocyte columns, which are a hallmark of growth plate architecture, play a central role in bone elongation. Columns are formed by clonal expansion following rotation of the division plane, resulting in a stack of cells oriented parallel to the growth
Sarah Rubin +8 more
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pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
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Eccentrically-compressed reinforced concrete columns strengthened with partial jacketing
Revista ALCONPAT, 2018 The behavior of six uniaxial compression columns is investigated. Specimen featured an initial section of (120 x 200) mm2, a final section of (200 x 200) mm2 and height of 1.600 mm, strengthened on the tensile and compression sides with plaster or not ...
Denio Ramam Carvalho de Oliveira +2 more
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Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations
FEBS Letters, EarlyView.The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas +6 more
wiley +1 more source