Results 1 to 10 of about 11,656,079 (296)

Combination of “combinations of p values” [PDF]

open access: yesEmpirical Economics, 2017
We investigate the impact of an uncertain number of false individual null hypotheses on commonly used p value combination methods. Under such uncertainty, these methods perform quite differently and often yield conflicting results. Consequently, we develop a combination of “combinations of p values” (CCP) test aimed at maintaining good power properties
Xuguang Sheng, Lan Cheng
openaire   +2 more sources

Novel Developments to Enable Treatment of CNS Diseases with Targeted Drug Delivery

open access: yesPharmaceutics, 2023
The blood-brain barrier (BBB) is a major hurdle for the development of systemically delivered drugs against diseases of the central nervous system (CNS).
Axel H. Meyer   +5 more
doaj   +1 more source

Combination of VLBI Intensive Sessions with GNSS for generating Low latency Earth Rotation Parameters [PDF]

open access: yesAdvances in Geosciences, 2019
The Earth Orientation Parameters (EOPs) are published by the Earth Orientation Centre of the International Earth Rotation and Reference Systems Service (IERS). They are provided as the low-latency Bulletin A and the 30 d latency long-term EOP time
H. Hellmers   +4 more
doaj   +1 more source

Immunogenicity of influenza vaccine in elderly people: a systematic review and meta-analysis of randomized controlled trials, and its association with real-world effectiveness

open access: yesHuman Vaccines & Immunotherapeutics, 2020
Background: Older people (≥60 years old) are particularly vulnerable to influenza virus infection, and vaccine is effective in reducing the disease burden in this population. However, it remains obscure whether their antibody response is lower than those
Ziyan Meng   +6 more
doaj   +1 more source

Identifying Potential Candidate Hub Genes and Functionally Enriched Pathways in the Immune Responses to Quadrivalent Inactivated Influenza Vaccines in the Elderly Through Co-Expression Network Analysis

open access: yesFrontiers in Immunology, 2020
Insights into the potential candidate hub genes may facilitate the generation of safe and effective immunity against seasonal influenza as well as the development of personalized influenza vaccines for the elderly at high risk of influenza virus ...
Jing Yang   +17 more
doaj   +1 more source

Combining analyses, combining optimizations [PDF]

open access: yesACM Transactions on Programming Languages and Systems, 1995
Modern optimizing compilers use several passes over a program's intermediate representation to generate good code. Many of these optimizations exhibit a phase-ordering problem. Getting the best code may require iterating optimizations until a fixed point is reached.
Cliff Click, Keith D. Cooper
openaire   +1 more source

Review of novel functions and implications of circular RNAs in hepatocellular carcinoma

open access: yesFrontiers in Oncology, 2023
Hepatocellular carcinoma (HCC) is one of the most frequent malignancies, with high incidence and mortality. As the majority of HCC patients are diagnosed at an advanced stage and die of recurrence and metastasis, its pathology and new biomarkers are ...
Zheng Liu   +3 more
doaj   +1 more source

Hsa_circ_0003602 Contributes to the Progression of Colorectal Cancer by Mediating the miR-149-5p/SLC38A1 Axis

open access: yesGut and Liver, 2023
Background/Aims: We aimed to investigate the role and working mechanism of Homo sapiens circular RNA_0003602 (hsa_circ_0003602) in colorectal cancer (CRC) development.
Rong Wu   +4 more
doaj   +1 more source

Anti-inflammatory activity of berberine in non-alcoholic fatty liver disease via the Angptl2 pathway

open access: yesBMC Immunology, 2020
Background Nonalcoholic fatty liver disease (NAFLD) has become the most common liver disease worldwide. Recent studies have shown that the Angptl2 pathway mediated hepatic inflammatory response plays an important role in the progression of nonalcoholic ...
Zengsheng Lu   +4 more
doaj   +1 more source

Dupilumab as a combination therapy to oral systemic immunomodulators for moderate-to-severe atopic dermatitis for skin of color children in resource-limited setting: A case series

open access: yesIndian Journal of Paediatric Dermatology, 2023
Subcutaneous dupilumab, with or without topical therapy, is clinically proven to treat children with moderate-to-severe atopic dermatitis (AD). However, this well-researched biologic for AD in children is still among the most expensive medication in the ...
Siti Nuraihan   +3 more
doaj   +1 more source

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