Results 1 to 10 of about 11,656,079 (296)
Combination of “combinations of p values” [PDF]
We investigate the impact of an uncertain number of false individual null hypotheses on commonly used p value combination methods. Under such uncertainty, these methods perform quite differently and often yield conflicting results. Consequently, we develop a combination of “combinations of p values” (CCP) test aimed at maintaining good power properties
Xuguang Sheng, Lan Cheng
openaire +2 more sources
Novel Developments to Enable Treatment of CNS Diseases with Targeted Drug Delivery
The blood-brain barrier (BBB) is a major hurdle for the development of systemically delivered drugs against diseases of the central nervous system (CNS).
Axel H. Meyer +5 more
doaj +1 more source
Combination of VLBI Intensive Sessions with GNSS for generating Low latency Earth Rotation Parameters [PDF]
The Earth Orientation Parameters (EOPs) are published by the Earth Orientation Centre of the International Earth Rotation and Reference Systems Service (IERS). They are provided as the low-latency Bulletin A and the 30 d latency long-term EOP time
H. Hellmers +4 more
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Background: Older people (≥60 years old) are particularly vulnerable to influenza virus infection, and vaccine is effective in reducing the disease burden in this population. However, it remains obscure whether their antibody response is lower than those
Ziyan Meng +6 more
doaj +1 more source
Insights into the potential candidate hub genes may facilitate the generation of safe and effective immunity against seasonal influenza as well as the development of personalized influenza vaccines for the elderly at high risk of influenza virus ...
Jing Yang +17 more
doaj +1 more source
Combining analyses, combining optimizations [PDF]
Modern optimizing compilers use several passes over a program's intermediate representation to generate good code. Many of these optimizations exhibit a phase-ordering problem. Getting the best code may require iterating optimizations until a fixed point is reached.
Cliff Click, Keith D. Cooper
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Review of novel functions and implications of circular RNAs in hepatocellular carcinoma
Hepatocellular carcinoma (HCC) is one of the most frequent malignancies, with high incidence and mortality. As the majority of HCC patients are diagnosed at an advanced stage and die of recurrence and metastasis, its pathology and new biomarkers are ...
Zheng Liu +3 more
doaj +1 more source
Background/Aims: We aimed to investigate the role and working mechanism of Homo sapiens circular RNA_0003602 (hsa_circ_0003602) in colorectal cancer (CRC) development.
Rong Wu +4 more
doaj +1 more source
Anti-inflammatory activity of berberine in non-alcoholic fatty liver disease via the Angptl2 pathway
Background Nonalcoholic fatty liver disease (NAFLD) has become the most common liver disease worldwide. Recent studies have shown that the Angptl2 pathway mediated hepatic inflammatory response plays an important role in the progression of nonalcoholic ...
Zengsheng Lu +4 more
doaj +1 more source
Subcutaneous dupilumab, with or without topical therapy, is clinically proven to treat children with moderate-to-severe atopic dermatitis (AD). However, this well-researched biologic for AD in children is still among the most expensive medication in the ...
Siti Nuraihan +3 more
doaj +1 more source

