Results 51 to 60 of about 1,060,375 (218)

Drugs and driving in New Zealand: An approach to THC culpability

, 2006
For years statistical analysis has been applied to different areas of the natural and applied sciences to determine the degree of confidence that can be placed in research results.
Troncoso Vergara, Carolina
core  

Different methodological approaches to the assessment of in vivo efficacy of three artemisinin-based combination antimalarial treatments for the treatment of uncomplicated falciparum malaria in African children.

, 2008
BACKGROUND: Use of different methods for assessing the efficacy of artemisinin-based combination antimalarial treatments (ACTs) will result in different estimates being reported, with implications for changes in treatment policy.
Pinoges Loretxu, Balkan, S, Grant Dorsey, Pinoges, Loretxu, Hasifa Burkirwa, Olliaro, P, Pedro Pablo Palma Urruta, Checchi, Francesco, Ingrid van den Broek, Dorsey Grant, Urruta, P P P, Walter R Taylor, Michel van Herp, Ashley Elizabeth A, Dorsey, G, van Herp Michel, Turyakira, Eleanor, Guthmann, Jean-Paul, Ashley, Elizabeth A, Zongo Issaka, Taylor Walter R, van Herp, M, Francesco Checchi, Issaka Zongo, Turyakira, E, Zongo, I, Taylor, W R J, Balkan Suna, Dorsey, Grant, van den Broek Ingrid, van Herp, Michel, Ashley, E A, van den Broek, Ingrid, Taylor, Walter R, Urruta, Pedro Pablo Palma, Elizabeth A Ashley, Eleanor Turyakira, Olliaro Piero, Pinoges, L, Jean-Paul Guthmann, Guthmann, J P, Guthmann Jean-Paul, van den Broek, I, Piero Olliaro, Zongo, Issaka, Checchi Francesco, Bukirwa, H, Checchi, F, Loretxu Pinoges, Bukirwa, Hasifa, Turyakira Eleanor, Suna Balkan, Bukirwa Hasifa, Urruta Pedro, Balkan, Suna, Olliaro, Piero   +55 more
core   +1 more source

Experimental Evolution of Resistance to Artemisinin Combination Therapy Results in Amplification of the mdr1 Gene in a Rodent Malaria Parasite [PDF]

, 2010
Background: Lacking suitable alternatives, the control of malaria increasingly depends upon Artemisinin Combination Treatments (ACT): resistance to these drugs would therefore be disastrous.
Sanchez Cecília P., Rodrigues Louise A., Louise A. Rodrigues, Hunt Paul, Sanchez, Cecília P, Hunt, Paul, Axel Martinelli, Rodrigues, Louise A, Borges, Sofia T, Henriques, Gisela, Martinelli Axel, Cecília P Sanchez, Henriques Gisela, Cecília P. Sanchez, Louise A Rodrigues, Sofia T. Borges, Borges Sofia T., Sanchez, Cecilia P., Borges, Sofia T., Sofia T Borges, Pedro Cravo, Martinelli, Axel, Gisela Henriques, Paul Hunt, Cravo, Pedro, Cravo Pedro, Rodrigues, Louise A.   +26 more
core   +1 more source

Mixed‐class J‐domain protein scaffolds promote expanded aggregate handling and multivalent Hsp70 engagement during functional disaggregase assembly

FEBS Letters, EarlyView.
Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
wiley   +1 more source

Pharmaceutical Management and Prescribing Pattern of Antimalarial Drugs in the Public Health Facilities in Dar-es-salaam, Tanzania [PDF]

, 2011
Despite the efforts of minimizing utilization of limited financial resources in Tanzania, there are still some factors that affect the whole system of supply chain of antimalarial medicines.
Silumbe, Richard S
core  

Decoding the dynamic extracellular matrix in cancer—3D models and bioscaffolds rewire the rules of tumor progression

FEBS Letters, EarlyView.
Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani, Konstantinos Spanopoulos, Zoi Piperigkou, Nikos K. Karamanos   +3 more
wiley   +1 more source

Should New Anti-Malarial Drugs be Subsidized? [PDF]

We use analytical and numerical models to explain and quantify the welfare effects of subsidies for artemisinin combination treatments (ACTs), a valuable new class of antimalarial drugs.
Klein, Eili, Parry, Ian W.H., Smith, David L., Laxminarayan, Ramanan   +3 more
core  

Combination of two or more drugs in the same syringe among a national sample of people who regularly inject drugs in Australia, 2025

The Illicit Drug Reporting System (IDRS) has been conducted annually since 2000. The IDRS is a national drug monitoring system, designed to identify and track emerging trends of local and national concern in illicit drug use and markets.
Karlsson, Antonia, Sutherland, Rachel ; https://orcid.org/, Peacock, Amy   +2 more
core   +1 more source

A reiterative method for calculating the early bactericidal activity of antituberculosis drugs.

, 2002
Studies of early bactericidal activity (EBA) are important in the rapid evaluation of new antituberculosis drugs. Historically, these have concentrated on the log fall in the viable count in sputum during the first 48 hours of therapy.
Gillespie, Stephen H., Gillespie, Stephen H, Gosling, Roland D, Charalambous, Bambos M, Charalambous, Bambos M., Gosling, Roland D.   +5 more
core   +1 more source

Trends in malaria morbidity following the introduction of artesunate plus amodiaquine combination in M'lomp village dispensary, south-western Senegal. [PDF]

, 2008
BACKGROUND: In Thailand, South Africa and Zanzibar, a decrease in malaria morbidity was observed following the introduction of artemisinin-based combination therapy (ACT).
Senghor Paul, Sophie Sarrassat, Le Hesran, Jean Yves, Paul Senghor, Hesran Jean, Le Hesran, Jean-Yves, Senghor, Paul, Jean Yves Le Hesran, Sophie SophieSarrassat, Sarrassat, Sophie, Sarrassat Sophie, Jean Hesran   +11 more
core   +1 more source