Results 121 to 130 of about 1,037,326 (304)

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Forecast combination in revenue management demand forecasting.

The domain of multi level forecast combination is a challenging new domain containing a large potential for forecast improvements. This thesis presents a theoretical and experimental analysis of different types of forecast diversification on forecast ...
Riedel, Silvia
core  

Co-deposition of salmeterol and fluticasone propionate by a combination inhaler

, 2006
The combination of the long-acting β2-agonist, salmeterol xinafoate (salmeterol) and inhaled corticosteroid, fluticasone propionate (FP) (Seretide®/Advair®) has shown enhanced efficacy compared with concurrent administration of the two drugs from ...
Theophilus, A., Whitcher, B., Moore, A., Chrystyn, H., Prime, D., Rossomanno, S.   +5 more
core   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

An In Vitro Study Comparing the Conventional Step-Back Instrumentation Technique to a Combination Step-Back/Ultrasonic Technique [PDF]

, 1992
Cleaning and shaping the root canal system is an important phase of endodontic therapy, and must be performed thoroughly and completely if successful root canal therapy is to be expected.
Eberhardt, James A.
core  

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

A Model for Enhancing the Quality of Services in the Management of Social Security Healthcare in Mazandaran Province [PDF]

Journal of Mazandaran University of Medical Sciences
Background and purpose: The Family Physician Program is a community-based initiative designed to provide healthcare services to all members of society, regardless of age or gender, in a comprehensive, coordinated, continuous, and patient-centered manner.
Seyyed Ebrahim Jafari Kelarijani, Yaghoub Alavimatin, Davood Paydarfard   +2 more
doaj  

Managing complexity in the Parallel Sparse Grid Combination Technique

, 2014
Parallel implementation of the sparse grid combination technique in high dimensions presents many complexity challenges. We enumerate these challenges, classifying them respectively as computational, algorithmic, and software complexity.
Rendell, A.P., Southern, J., Roberts, S., Larson, J.W., Larson, Jay, Hegland, Markus, Rendell, Alistair, Harding, B., Ali, Muhammad, Hegland, M., Stals, Linda, Roberts, Stephen, Harding, Brendan, Stals, L., Strazdins, Peter, Strazdins, P.E., Ali, M.M.   +16 more
core   +1 more source