Results 121 to 130 of about 10,851,050 (358)

Could Upregulated Hsp70 Protein Compensate for the Hsp90-Silence-Induced Cell Death in Glioma Cells? [PDF]

, 2014
The molecular chaperone heat shock protein 90 alpha (Hsp90α) has been recognized in various tumours including glioma. This pilot study using a proteomic approach analyses the downstream effects of Hsp90 inhibition using 17-allylamino-17 ...
Khan, Zarine Jamsher, Munje, Chinmay, Shervington, Amal A, Shervington, Leroy Alexander   +3 more
core   +2 more sources

Combined antithrombotic therapy

Canadian Medical Association Journal, 2007
The study by Joseph Delaney and colleagues on the use of antithrombotic medications raises many important questions.[1][1] In several randomized controlled trials on coronary artery disease, giving oral anticoagulants to patients whose international normalized ratio was maintained between 2 and ...
openaire   +2 more sources

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source

The scientific basis of combination therapy for chronic hepatitis B functional cure

Nature reviews: Gastroenterology & hepatology, 2023
S. Lim, T. Baumert, C. Boni, E. Gane, M. Levrero, A. Lok, M. Maini, N. Terrault, F. Zoulim   +8 more
semanticscholar   +1 more source

Multimodal treatment for local recurrent malignant gliomas: resurgery and/or reirradiation followed by chemotherapy [PDF]

, 2019
The therapeutic management of recurrent malignant gliomas (MGs) is not determined. Therefore, the efficacy of a multimodal approach and a combination systemic therapy was investigated.
Bianco, Vincenzo, ELENA REBUZZI, Sara, Ferrara, Carla, Fusto, Carmela, GIRON BERRIOS, JULIO RODRIGO, Grassi, Massimiliano, Pecorari, Silvia, Prelaj, Arsela, Salvati, Maurizio, Stati, Valeria, Tomao, Silverio   +10 more
core   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

COMBINATION ANTIFUNGAL THERAPY FOR ONYCHOMYCOSIS

Indonesian Journal of Tropical and Infectious Disease, 2018
Onychomycosis is a fungal infection of the nail unit including the nail matrix, the nail bed and the nail plate by both dermatophyte and non-dermatophyte agents.
Nur Khamidah, Evy Ervianti
doaj   +1 more source

PD-1 combination therapy with IL-2 modifies CD8+ T cell exhaustion program

Nature, 2022
M. Hashimoto, K. Araki, M. Cardenas, Peng Li, R. Jadhav, H. Kissick, W. Hudson, D. McGuire, Rebecca C. Obeng, A. Wieland, Judong Lee, Daniel T. McManus, J. Ross, S. Im, JungHwa Lee, Jian-Xin Lin, B. Hu, E. West, Christopher D. Scharer, G. Freeman, A. Sharpe, S. Ramalingam, A. Pellerin, V. Teichgräber, W. Greenleaf, C. Klein, J. Goronzy, P. Umaña, W. Leonard, Kendall A. Smith, R. Ahmed   +30 more
semanticscholar   +1 more source

Analgesic effectiveness and tolerability of oral oxycodone/naloxone and pregabalin in patients with lung cancer and neuropathic pain. An observational analysis [PDF]

, 2016
INTRODUCTION: Cancer-related pain has a severe negative impact on quality of life. Combination analgesic therapy with oxycodone and pregabalin is effective for treating neuropathic cancer pain.
Borghesi, Cristina, De Santis, Stefano, Fulvi, Alberto, Giovannoni, Daniele, Marcassa, Claudio, Migliorino, Maria Rita, Ricciardi, Serena   +6 more
core   +2 more sources

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source