Results 131 to 140 of about 9,684,163 (368)

Highlights in Resistance Mechanism Pathways for Combination Therapy

Cells, 2019
Combination chemotherapy has been a mainstay in cancer treatment for the last 60 years. Although the mechanisms of action and signaling pathways affected by most treatments with single antineoplastic agents might be relatively well understood, most ...
João M A Delou, A. S. Souza, L. C. M. Souza, H. Borges   +3 more
semanticscholar   +1 more source

Cellular liquid biopsy provides unique chances for disease monitoring, preclinical model generation and therapy adjustment in rare salivary gland cancer patients

Molecular Oncology, EarlyView.
We quantified and cultured circulating tumor cells (CTCs) of 62 patients with various cancer types and generated CTC‐derived tumoroid models from two salivary gland cancer patients. Cellular liquid biopsy‐derived information enabled molecular genetic assessment of systemic disease heterogeneity and functional testing for therapy selection in both ...
Nataša Stojanović Gužvić, Florian Lüke, Steffi Treitschke, Andrea Coluccio, Martin Hoffmann, Giancarlo Feliciello, Adithi Ravikumar Varadarajan, Xin Lu, Kathrin Weidele, Catherine Botteron, Silvia Materna–Reichelt, Felix Keil, Katja Evert, Florian Weber, Thomas Schamberger, Michael Althammer, Jirka Grosse, Dirk Hellwig, Christian Schulz, Stephan Seitz, Peter Ugocsai, Anke Schlenska‐Lange, Roman Mayr, Ulrich Kaiser, Wolfgang Dietmaier, Bernhard Polzer, Jens Warfsmann, Kamran Honarnejad, Tobias Pukrop, Daniel Heudobler, Christoph A. Klein, Christian Werno   +31 more
wiley   +1 more source

Baseline anti-NS4a antibodies in combination with on-treatment quantitative HCV-RNA reliably identifies nonresponders to pegylated interferon-ribavirin combination therapy after 4 weeks of treatment [PDF]

, 2010
Background Early detection of nonresponders to hepatitis C therapy limits unnecessary exposure to treatment and its side-effects. A recent algorithm combining baseline anti-NS4a antibodies and on-treatment quantitative PCR identified nonresponders to a ...
de Knegt, Robert J, Desombere, Isabelle, Haagmans, Bart, Hansen, Bettina, Janssen, Harry LA, Leroux-Roels, Geert, Orlent, Hans, Schalm, Solko W, Van Vlierberghe, Hans   +8 more
core   +1 more source

Combination Therapy Strategies for the Treatment of Malaria

Molecules, 2019
Malaria is a vector- and blood-borne infection that is responsible for a large number of deaths around the world. Most of the currently used antimalarial therapeutics suffer from drug resistance.
S. Alven, B. Aderibigbe
semanticscholar   +1 more source

Combined spatially resolved metabolomics and spatial transcriptomics reveal the mechanism of RACK1‐mediated fatty acid synthesis

Molecular Oncology, EarlyView.
The authors analyzed the spatial distributions of gene and metabolite profiles in cervical cancer through spatial transcriptomic and spatially resolved metabolomic techniques. Pivotal genes and metabolites within these cases were then identified and validated.
Lixiu Xu, Jinqiu Li, Junqi Ma, Ayshamgul Hasim   +3 more
wiley   +1 more source

Adherence to self-administered tuberculosis treatment in a high HIV-prevalence setting: a cross-sectional survey in Homa Bay, Kenya. [PDF]

, 2012
Good adherence to treatment is crucial to control tuberculosis (TB). Efficiency and feasibility of directly observed therapy (DOT) under routine program conditions have been questioned.
AK Person, Apollo Odongo Aloo, B Blomberg, C Lienhardt, Claire Thorne, DK Mafigiri, DR Bangsberg, DR Bangsberg, Emmanuelle Espié, FA Kaona, Fabienne Nackers, Francis Varaine, G Fochsen, G Verma, H Huerga, Helena Huerga, J Connor, J Elizaga, J Macq, J Sim, J Volmink, Jean-François Etard, Jeremiah Chakaya, JH Oyugi, Joseph Sitienei, KR Amico, L Osterberg, L Tuyisenge, Maryline Bonnet, Mathieu Bastard, ME Raguenaud, MJ Selgelid, MS Pepe, N Awofeso, PE Meissner, R Steffen, RA Atun, S Bangalore, S Mannheimer, SA Munro, SB Mannheimer, SC Kalichman, SM Youngleson, TA Szakacs, TP Giordano, W Xu, WA Kaplan   +46 more
core   +5 more sources

Circulating tumor DNA (ctDNA) trajectories predict survival in trifluridine/tipiracil‐treated metastatic colorectal cancer patients

Molecular Oncology, EarlyView.
The authors applied joint/mixed models that predict mortality of trifluridine/tipiracil‐treated metastatic colorectal cancer patients based on circulating tumor DNA (ctDNA) trajectories. Patients at high risk of death could be spared aggressive therapy with the prospect of a higher quality of life in their remaining lifetime, whereas patients with a ...
Matthias Unseld, Stefan Kühberger, Ricarda Graf, Christine Beichler, Markus Braun, Nadia Dandachi, Ellen Heitzer, Gerald W. Prager   +7 more
wiley   +1 more source

Combination therapy for hypertension [PDF]

, 2003
published_or_final_versio
Cheung, BMY, Kumana, CR, Lau, CP
core  

Combination formoterol and budesonide as maintenance and reliever therapy versus combination inhaler maintenance for chronic asthma in adults and children. [PDF]

, 2013
BACKGROUND: Asthma is characterised by chronic inflammation of the airways and recurrent exacerbations with wheezing, chest tightness and cough. Treatment with inhaled steroids and bronchodilators often results in good control of symptoms, prevention of ...
Ferrara, G, Karner, C, Kew, KM, Mindus, SM   +3 more
core   +1 more source

Combination therapy to checkmate Glioblastoma: clinical challenges and advances

Clinical and Translational Medicine, 2018
Combination therapy is increasingly becoming the cornerstone of current day antitumor therapy. Glioblastoma multiforme is an aggressive brain tumor with a dismal median survival post diagnosis and a high rate of disease recurrence. The poor prognosis can
D. Ghosh, Saikat Nandi, S. Bhattacharjee
semanticscholar   +1 more source