Results 241 to 250 of about 1,635,060 (314)

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source

Correction: Enhancing glioblastoma therapy: unveiling synergistic anticancer effects of Onalespib - radiotherapy combination therapy. [PDF]

Front Oncol
Uffenorde J, Hariri M, Papalanis E, Staffas A, Berg J, Stenerlöw B, Berglund H, Malmberg C, Spiegelberg D.   +8 more
europepmc   +1 more source

Identifying gene expression signatures for risk stratification of postoperative adjuvant chemotherapy in colorectal cancer

FEBS Open Bio, EarlyView.
A novel signature integrating genome‐wide analysis with clinical factors predicts recurrence in stage II colorectal cancer and enables a new risk stratification to guide postoperative adjuvant chemotherapy. Clinical risk stratification for postoperative recurrence in patients with pathological stage II (pStage II) colorectal cancer (CRC) is essential ...
Mayuko Otomo, Keisuke Okuno, Shuichi Watanabe, Sakiko Oba, Hiroyasu Kagawa, Masanori Tokunaga, Daisuke Ban, Yusuke Kinugasa   +7 more
wiley   +1 more source

GLP-1RA plus SGLT2i combination therapy and liver fibrosis progression in MASLD with type 2 diabetes. [PDF]

Hepatol Commun
Choi J, Mitchell G, Nguyen VH, Przybyszewski E, Song J, Carroll A, Michta M, Almazan E, Simon TG, Chung RT.   +9 more
europepmc   +1 more source

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

New combination therapy of praziquantel and <i>Lactobacillus plantarum</i> for enhancing the treatment of clonorchiasis in mice. [PDF]

Food Waterborne Parasitol
Ma Y, Wang X, Zhang X, Yu Y, Liu Z, Bao P, Liu M, Wang Y, Yuan X, Wang H, Gong P, Zhang N, Li X, Li J.   +13 more
europepmc   +1 more source

Acute caffeine treatment protects the developing retina from ischemia‐induced cell death

FEBS Open Bio, EarlyView.
Caffeine reduces cell death in the developing retina under ischemia (OGD). This effect does not involve BDNF upregulation or antioxidant pathways (NRF2/VEGF). Neuroprotection occurs mainly through adenosine A2A receptor antagonism, decreasing glutamate release and excitotoxicity, highlighting caffeine's potential as an acute neuroprotective agent in ...
Amanda Alves Nascimento, Danniel Pereira‐Figueiredo, Gabriella Grossi de Lima Dias, Gabriel Ferreira dos Santos, Mariana Rodrigues Pereira, Rafael Brito, Karin C Calaza   +6 more
wiley   +1 more source

In vitro evidence to support amphotericin B and flucytosine combination therapy for talaromycosis. [PDF]

PLoS Negl Trop Dis
Natesan Sambath H, Vitsupakorn S, Sreerama Reddy K, Brown L, Nguyen TTM, Burke M, Liu J, Evans E, Giamberardino C, Perfect J, Hoa NT, Le T.   +11 more
europepmc   +1 more source

Case Report: Safety and efficacy of combination therapy with adalimumab and anakinra in two patients with severe inflammatory diseases. [PDF]

Front Pediatr
Coslovich S, Bramuzzo M, Pastore S, Chicco D, Lega S, Gortani G, Caiffa T, Tommasini A, Taddio A.   +8 more
europepmc   +1 more source