Results 281 to 290 of about 10,851,050 (358)

BMI‐1 modulation and trafficking during M phase in diffuse intrinsic pontine glioma

FEBS Open Bio, EarlyView.
The schematic illustrates BMI‐1 phosphorylation during M phase, which triggers its translocation from the nucleus to the cytoplasm. In cycling cells, BMI‐1 functions within the PRC1 complex to mediate H2A K119 monoubiquitination. Following PTC596‐induced M phase arrest, phosphorylated BMI‐1 dissociates from PRC1 and is exported to the cytoplasm via its
Banlanjo Umaru, Deepak Kumar Mishra, Shiva Senthil Kumar, Hao‐Han Pang, Brendan Devine, Komal Khan, Rachid Drissi   +6 more
wiley   +1 more source

The cooperative regulation of miR‐221 by APE1 and AUF1 impacts p27Kip1 defining a miR signature relevant for cervical cancer

FEBS Open Bio, EarlyView.
A regulatory axis involving APE1, AUF1, and miR‐221 is proposed. Pri‐miR‐221 is processed by DROSHA and DICER to generate mature miR‐221, which targets p27Kip1 mRNA. APE1 and AUF1 compete for pre‐miR‐221 binding. Reduced APE1/AUF1 levels impair miR‐221 biogenesis, decrease p27Kip1 mRNA degradation, and promote cell cycle progression, chemoresistance ...
Matilde Clarissa Malfatti, Nicolò Gualandi, Gianluca Tell, Giulia Antoniali   +3 more
wiley   +1 more source

Therapeutic potential of metformin-based combination therapy in acute myeloid leukemia. [PDF]

Discov Oncol
Shamahmood MN, Miri A, Yousefi MJ, Mezginejad F.   +3 more
europepmc   +1 more source

Initial triple combination therapy including sotatercept in a patient with severe idiopathic pulmonary arterial hypertension: a case report. [PDF]

ERJ Open Res
Park DH, Kamp JC, Seeliger B, Hoeper MM, Olsson KM.   +4 more
europepmc   +1 more source

Comparative Analysis of Clinical Outcomes in Patients With Type 2 Diabetes Mellitus on Monotherapy Versus Combination Therapy. [PDF]

Cureus
Mahapatra H, Gupta PK, Paul A, Nampalliwar A, Bansal M, Das B, Namboothiri KP.   +6 more
europepmc   +1 more source

Efficacy and safety of Ruxolitinib-based combination therapy in the patients with Myelofibrosis (MF): a systematic review and meta-analysis. [PDF]

Ann Med
Tan S, Li Y, Cao Y, Sun W, Hui W.
europepmc   +1 more source

Combination Therapy with Copanlisib and Niraparib in Patients with Recurrent Endometrial and Ovarian Cancer (COPANIRA): Efficacy, Toxicity, and Translational Insights. [PDF]

Clin Cancer Res
Brodsky AL, Asare A, Fellman B, Anderson K, Yao J, Lee S, Tran H, Xu X, Liu J, Celestino J, Hajek RA, Morgan MB, Mohammad M, Soliman P, Shafer A, Sood AK, Bodurka D, Fleming ND, Onstad Grinsfelder M, Milojevic L, Jazaeri AA, Mills GB, Coleman RL, Westin SN.   +23 more
europepmc   +1 more source

Strain diversity drives heterogeneous responses to tuberculosis combination therapy

Yoon MH, Culviner PH, Moraes MP, Nitta H, Thuong NTT, Fortune SM, Aldridge BB.   +6 more
europepmc   +1 more source