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Dynamic combinatorial chemistry

Drug Discovery Today, 2002
A combinatorial library that responds to its target by increasing the concentration of strong binders at the expense of weak binders sounds ideal. Dynamic combinatorial chemistry has the potential to achieve exactly this.
Ricardo Furlan, Jeremy Keith Morris Sanders, Sijbren Otto   +2 more
exaly   +4 more sources

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ChemInform Abstract: Resin Capture Techniques in Combinatorial Chemistry

ChemInform, 2000
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
A. Chucholowski, M. Nettekoven
openaire   +1 more source

ChemInform Abstract: Combinatorial Chemistry Techniques Applied to Nonpeptide Integrin Antagonists

ChemInform, 1998
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
W. J. HOEKSTRA, B. L. POULTER
openaire   +1 more source

RECAPRetrosynthetic Combinatorial Analysis Procedure:  A Powerful New Technique for Identifying Privileged Molecular Fragments with Useful Applications in Combinatorial Chemistry

Journal of Chemical Information and Computer Sciences, 1998
The use of combinatorial chemistry for the generation of new lead molecules is now a well established strategy in the drug discovery process. Central to the use of combinatorial chemistry is the design and availability of high quality building blocks which are likely to afford hits from the libraries that they generate.
Xiao Qing Lewell, Duncan B. Judd, Stephen P. Watson, Michael M. Hann   +3 more
openaire   +3 more sources

Direct-Injection NMR (DI-NMR):  A Flow NMR Technique for the Analysis of Combinatorial Chemistry Libraries

Journal of Combinatorial Chemistry, 2000
A new tool for analyzing compound libraries by NMR has been developed. Aliquots of solution-state samples (between 120 and 350 microL) are directly injected, using a standard liquids handler, into an NMR (LC-NMR) flow probe. Automated NMR software tracks--and suppresses--intense signals arising from the nondeuterated solvents used (if any) and acquires
P A, Keifer, S H, Smallcombe, E H, Williams, K E, Salomon, G, Mendez, J L, Belletire, C D, Moore   +6 more
openaire   +2 more sources

Combinatorial chemistry synthesis techniques

Proceedings of the 19th Annual International Conference of the IEEE Engineering in Medicine and Biology Society. 'Magnificent Milestones and Emerging Opportunities in Medical Engineering' (Cat. No.97CH36136), 2002
As pharmaceutical companies race to find new and novel drugs faster, the tools of combinatorial chemistry are increasingly playing a larger role. Chemists can now prepare hundreds or thousands of analogs simultaneously to reveal structure-activity relationships (SAR) all at once and potentially shorten the discovery process for new drugs by years.
openaire   +1 more source

Analytical Techniques for Combinatorial Chemistry:  Quantitative Infrared Spectroscopic Measurements of Deuterium-Labeled Protecting Groups

Journal of the American Chemical Society, 1996
Infrared microspectroscopy has been developed as a powerful, nondestructive technique for the quantitative analysis of solid-phase, resin-bound chemical reactions. The synthesis and/or application of deuterium isotope containing protecting groups, including acetyl-d3 chloride, benzoyl-d5 chloride, and 2-[[[(tert-butyl-d9)oxy]carbonyl]oximino]-2 ...
Keith Russell, Derek C. Cole, Frances M. McLaren, Don. E. Pivonka   +3 more
openaire   +1 more source

Investigation of Solid-Phase Peptide Synthesis by the Near-Infrared Multispectral Imaging Technique:  A Detection Method for Combinatorial Chemistry

Analytical Chemistry, 1999
A near-infrared (NIR) multispectral imaging spectrometer was used to monitor solid-phase peptide synthesis. This imaging spectrometer has fast scanning ability and high sensitivity because it is based on an acousto-optic tunable filter and a NIR InGaAs focal plane array camera.
M, Fischer, C D, Tran
openaire   +2 more sources

ChemInform Abstract: RECAP — Retrosynthetic Combinatorial Analysis Procedure: A Powerful New Technique for Identifying Privileged Molecular Fragments with Useful Applications in Combinatorial Chemistry.

ChemInform, 1998
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
X. Q. LEWELL, D. B. JUDD, S. P. WATSON, M. M. HANN   +3 more
openaire   +1 more source

High-resolution NMR techniques for solid-phase synthesis and combinatorial chemistry

Drug Discovery Today, 1997
Recent developments in NMR spectroscopy have created two complementary categories of analysis for drug discovery processes. The first category includes techniques for obtaining high-resolution (especially 1H) NMR spectra of compounds still bound to solid-phase synthesis resins.
openaire   +1 more source