Results 21 to 30 of about 7,603,109 (259)

Discovery of Antibacterial Manganese(I) Tricarbonyl Complexes through Combinatorial Chemistry [PDF]

, 2023
The continuous rise of antimicrobial resistance is a serious threat to human health and already causing hundreds of thousands of deaths each year. While natural products and synthetic organic small molecules have provided the majority of our current ...
Giorgio, Pelosi, Silvana , Pienlli, Angelo, Frei, Mirco, Scaccaglia   +3 more
core   +2 more sources

Upgrading SELEX Technology by Using Lambda Exonuclease Digestion for Single-Stranded DNA Generation

Molecules, 2009
The generation of single-stranded DNA (ssDNA) molecules plays a key role in the SELEX (Systematic Evolution of Ligands by EXponential enrichment) combinatorial chemistry process and numerous molecular biology techniques and applications, such as DNA ...
Meltem Avci-Adali, Angel Paul, Nadj Wilhelm, Gerhard Ziemer, Hans Peter Wendel   +4 more
doaj   +1 more source

Isolation of antigen-specific, disulphide-rich knob domain peptides from bovine antibodies.

PLoS Biology, 2020
As a novel alternative to established surface display or combinatorial chemistry approaches for the discovery of therapeutic peptides, we present a method for the isolation of small, cysteine-rich domains from bovine antibody ultralong complementarity ...
Alex Macpherson, Anthony Scott-Tucker, Anastasios Spiliotopoulos, Catherine Simpson, Justin Staniforth, Adam Hold, James Snowden, Leah Manning, Jean van den Elsen, Alastair D G Lawson   +9 more
doaj   +1 more source

Microbial Identification, High-Resolution Microscopy and Spectrometry of the Rhizosphere in Its Native Spatial Context

Frontiers in Plant Science, 2021
During the past decades, several stand-alone and combinatorial methods have been developed to investigate the chemistry (i.e., mapping of elemental, isotopic, and molecular composition) and the role of microbes in soil and rhizosphere.
Chaturanga D. Bandara, Matthias Schmidt, Yalda Davoudpour, Hryhoriy Stryhanyuk, Hans H. Richnow, Niculina Musat   +5 more
doaj   +1 more source

Ultrasonic surface acoustic wave-assisted separation of microscale droplets with varying acoustic impedance

Ultrasonics Sonochemistry, 2023
In droplet-based microfluidic platforms, precise separation of microscale droplets of different chemical composition is increasingly necessary for high-throughput combinatorial chemistry in drug discovery and screening assays.
Mushtaq Ali, Jinsoo Park
doaj   +1 more source

When plants produce not enough or at all: metabolic engineering of flavonoids in microbial hosts

Frontiers in Plant Science, 2015
Flavonoid metabolism and its fascinating molecules that are natural products in plants, have attracted the attention of industry and researchers involved in plant science, nutrition, bio/chemistry, chemical bioengineering, pharmacy, medicine, etc., since
Emmanouil Antonios Trantas, Mattheos eKoffas, Peng eXu, Filippos eVerveridis   +3 more
doaj   +1 more source

Combinatorial solid-phase synthesis of 4,6-diaryl and 4-aryl, 6-alkyl-1,3,5-triazines and their application to efficient biofuel production

, 2012
10.1021/co300007aACS Combinatorial Science147395 ...
Kim, Jaoon Y. H., Lee, Y., Chang, Young-Tae, Ha, H.-H., Lee, Woo Sirl, Lee, J.W., Chang, Y.-T., Bork, J.T., Lee, W.S., Vendrell, M., Ha, Hyung-Ho, Kim, J.Y.H., Lee, Y, Bork, Jacqueline T., Lee, Jae Wook, Vendrell, Marc   +15 more
core   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Omics based approach for biodiscovery of microbial natural products in antibiotic resistance era

Journal of Genetic Engineering and Biotechnology, 2018
The need for a new antibiotic pipeline to confront threat imposed by resistant pathogens has become a major global concern for human health. To confront the challenge there is a need for discovery and development of new class of antibiotics. Nature which
N. Chandra Mohana, H.C. Yashavantha Rao, D. Rakshith, P.R. Mithun, B.R. Nuthan, S. Satish   +5 more
doaj   +1 more source

Novel Screening Technique: Integrated Combinatorial Green Chemistry & Life Cycle Analysis (CGC-LCA)

BioResources, 2013
The integration of combinatorial green chemistry (CGC), a more benign approach to combinatorial chemistry, with environmental life cycle assessment (LCA) methodologies as an improved process development methodology is discussed. It is expected that the CGC approach will require less labor and result in more globally optimized assay results, leading to ...
Carter W. Reeb, Lucian A. Lucia, Richard A. Venditti   +2 more
openaire   +2 more sources