Results 21 to 30 of about 16,727 (234)
Versatile Monitoring Tools in Parallel Solid-Phase Synthesis
CHIMIA, 2003 Parallel synthesis on solid-phase is routinely applied in our combinatorial chemistry efforts for lead finding and lead optimization in drug discovery.
Eduard R. Felder +3 more
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Novel Screening Technique: Integrated Combinatorial Green Chemistry & Life Cycle Analysis (CGC-LCA)
BioResources, 2013 The integration of combinatorial green chemistry (CGC), a more benign approach to combinatorial chemistry, with environmental life cycle assessment (LCA) methodologies as an improved process development methodology is discussed. It is expected that the CGC approach will require less labor and result in more globally optimized assay results, leading to ...
Carter W. Reeb +2 more
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PLoS Biology, 2004 Biological in vitro selection techniques, such as RNA aptamer methods and mRNA display, have proven to be powerful approaches for engineering molecules with novel functions.
David R Halpin, Pehr B Harbury
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ADMET and DMPK, 2020 Approximately two-third of the compounds in the pharmaceutical industry were developed through combinatorial chemistry and high throughput screening of particulate solids.
Shashi Kiran Misra, Kamla Pathak
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Upgrading SELEX Technology by Using Lambda Exonuclease Digestion for Single-Stranded DNA Generation
Molecules, 2009 The generation of single-stranded DNA (ssDNA) molecules plays a key role in the SELEX (Systematic Evolution of Ligands by EXponential enrichment) combinatorial chemistry process and numerous molecular biology techniques and applications, such as DNA ...
Meltem Avci-Adali +4 more
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Ultrasonics Sonochemistry, 2023 In droplet-based microfluidic platforms, precise separation of microscale droplets of different chemical composition is increasingly necessary for high-throughput combinatorial chemistry in drug discovery and screening assays.
Mushtaq Ali, Jinsoo Park
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Isolation of antigen-specific, disulphide-rich knob domain peptides from bovine antibodies.
PLoS Biology, 2020 As a novel alternative to established surface display or combinatorial chemistry approaches for the discovery of therapeutic peptides, we present a method for the isolation of small, cysteine-rich domains from bovine antibody ultralong complementarity ...
Alex Macpherson +9 more
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Frontiers in Plant Science, 2021 During the past decades, several stand-alone and combinatorial methods have been developed to investigate the chemistry (i.e., mapping of elemental, isotopic, and molecular composition) and the role of microbes in soil and rhizosphere.
Chaturanga D. Bandara +5 more
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When plants produce not enough or at all: metabolic engineering of flavonoids in microbial hosts
Frontiers in Plant Science, 2015 Flavonoid metabolism and its fascinating molecules that are natural products in plants, have attracted the attention of industry and researchers involved in plant science, nutrition, bio/chemistry, chemical bioengineering, pharmacy, medicine, etc., since
Emmanouil Antonios Trantas +3 more
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Omics based approach for biodiscovery of microbial natural products in antibiotic resistance era
Journal of Genetic Engineering and Biotechnology, 2018 The need for a new antibiotic pipeline to confront threat imposed by resistant pathogens has become a major global concern for human health. To confront the challenge there is a need for discovery and development of new class of antibiotics. Nature which
N. Chandra Mohana +5 more
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