Results 41 to 50 of about 7,603,109 (259)

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source

Combinatorial representations [PDF]

, 2011
23pp. Submitted to J. Combinatorial Theory (Series A)arXiv:1109.1216v1 [math.CO]23pp. Submitted to J. Combinatorial Theory (Series A)23pp. Submitted to J.
Maximilien Gadouleau, Cameron, PJ, Gadouleau, M, Riis, S, Cameron, Peter J., Riis, Soren, Gadouleau, Maximilien, Cameron, Peter Jephson, Riis, Søren, Søren Riis, Peter J. Cameron   +10 more
core   +1 more source

Natural product-like combinatorial libraries

Journal of the Brazilian Chemical Society, 2003
Combinatorial chemistry has emerged over the last few years as an important tool for drug discovery and lead optimisation. In this approach, the molecular diversity and range of biological properties displayed by secondary metabolites constitutes a ...
Abreu Pedro M., Branco Paula S.
doaj  

A Case Study of an Antibiotic Discovery Laboratory Autonomous Learning Assignment—An Evaluation of Undergraduate Students’ Disciplinary Bias

Education Sciences
Current higher education trends are moving towards interdisciplinary curricula to provide new tools for solving complex issues. However, course design and learning tracks still create divisions between scientific disciplines. This study aimed to evaluate
Nadav Badrian, Lilach Iasur-Kruh, Yael Ungar, Iris Sonia Weitz   +3 more
doaj   +1 more source

Single Domain Antibodies as New Biomarker Detectors

Diagnostics, 2017
Biomarkers are defined as indicators of biological processes, pathogenic processes, or pharmacological responses to a therapeutic intervention. Biomarkers have been widely used for early detection, prediction of response after treatment, and for ...
Chiuan Herng Leow, Katja Fischer, Chiuan Yee Leow, Qin Cheng, Candy Chuah, James McCarthy   +5 more
doaj   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Cathelicidins - Nature's attempt at combinatorial chemistry

, 2005
Cathelicidins are a family of diverse antimicrobial peptides found in granules of mammalian neutrophils. Cathelicidins are active against a broad range of microbes in different environments.
Borregaard, N, Sørensen, Ole E,, Lund University.   +2 more
core   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Novel Affinity Ligands for Chromatography Using Combinatorial Chemistry

, 2011
Spatially addressable combinatorial libraries were synthesized by solution phase chemistry and screened for binding to human serum albumin. Members of arylidene diamide libraries were among the best hits found, having submicromolar binding affinities ...
Gallion, SL, Eckersten, A, Joseph C. Hogan, Eckersten, Ann, Fagerstam, L, Lindquist, C,, Hogan, JCJ, Yasuro Shinohara, Charlotta Lindquist, Ellström, Christel, Lars Fagerstam, Pilotti, Åke,, Shinohara, Y, Regberg, T, Ake Pilotti, Ann Eckersten, Ellstrom, C, Regberg, Tor, Christel Ellstrom, Steven L. Gallion, Tor Regberg, Lindquist, Charlotta,, Hogan, Joseph C., Jr., Fagerstam, Lars, Shinohara, Yasuro, Gallion, Steven L., Pilotti, A   +26 more
core   +1 more source

Current Perspectives on Aptamers as Diagnostic Tools and Therapeutic Agents

Pharmaceutics, 2020
Aptamers are synthetic single-stranded DNA or RNA sequences selected from combinatorial oligonucleotide libraries through the well-known in vitro selection and iteration process, SELEX.
Prabir Kumar Kulabhusan, Babar Hussain, Meral Yüce   +2 more
doaj   +1 more source