Results 41 to 50 of about 73,416 (270)

High-throughput in-situ characterization and modelling of precipitation kinetics in compositionally graded alloys [PDF]

, 2015
The development of new engineering alloy chemistries is a time consuming and iterative process. A necessary step is characterization of the nano/microstructure to provide a link between the processing and properties of each alloy chemistry considered ...
De Geuser, F., Deschamps, A., Hutchinson, C. R., Styles, M. J.   +3 more
core   +3 more sources

Omics based approach for biodiscovery of microbial natural products in antibiotic resistance era

Journal of Genetic Engineering and Biotechnology, 2018
The need for a new antibiotic pipeline to confront threat imposed by resistant pathogens has become a major global concern for human health. To confront the challenge there is a need for discovery and development of new class of antibiotics. Nature which
N. Chandra Mohana, H.C. Yashavantha Rao, D. Rakshith, P.R. Mithun, B.R. Nuthan, S. Satish   +5 more
doaj   +1 more source

Novel Screening Technique: Integrated Combinatorial Green Chemistry & Life Cycle Analysis (CGC-LCA)

BioResources, 2013
The integration of combinatorial green chemistry (CGC), a more benign approach to combinatorial chemistry, with environmental life cycle assessment (LCA) methodologies as an improved process development methodology is discussed. It is expected that the CGC approach will require less labor and result in more globally optimized assay results, leading to ...
Carter W. Reeb, Lucian A. Lucia, Richard A. Venditti   +2 more
openaire   +2 more sources

Micro- and nanoengineering approaches to control stem cell-biomaterial interactions. [PDF]

, 2011
As our population ages, there is a greater need for a suitable supply of engineered tissues to address a range of debilitating ailments. Stem cell based therapies are envisioned to meet this emerging need. Despite significant progress in controlling stem
Dokmeci, Mehmet R, Dolatshahi-Pirouz, Alireza, Khademhosseini, Ali, Kolind, Kristian, Nikkhah, Mehdi   +4 more
core   +2 more sources

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Phage display screening of therapeutic peptide for cancer targeting and therapy

Protein & Cell, 2019
Recently, phage display technology has been announced as the recipient of Nobel Prize in Chemistry 2018. Phage display technique allows high affinity target-binding peptides to be selected from a complex mixture pool of billions of displayed peptides on ...
Phei Er Saw, Er-Wei Song
doaj   +1 more source

The Journal of Computer-Aided Molecular Design: a bibliometric note [PDF]

, 2011
Summarizes the articles in, and the citations to, volumes 2-24 of the Journal of Computer-Aided Molecular Design. The citations to the journal come from almost 2000 different sources that span a very wide range of academic subjects, with the most heavily
Willett, P.
core   +2 more sources

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Scaffold searching: automated identification of similar ring systems for the design of combinatorial libraries [PDF]

, 2003
Rigid ring systems can be used to position receptor-binding functional groups in 3D space and they thus play an increasingly important role in the design of combinatorial libraries.
Bohl, M., Dunbar, J., Gifford, E.M., Heritage, T., Wild, D.J., Willett, P., Wilton, D.J.   +6 more
core   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source