Results 51 to 60 of about 73,416 (270)

Structure and singly occupied molecular orbital analysis of anionic tautomers of guanine [PDF]

, 2008
Recently we reported the discovery of adiabatically bound anions of guanine which might be involved in the processes of DNA damage by low-energy electrons and in charge transfer through DNA.
Abdoul-Carime, Aflatooni, Aflatooni, Atkins, Bachorz, Berlin, Bixo, Boudaïffa, Cai, Cai, Carhart, Dolgounitcheva, Downs, Downs, Frisch, Gutowski, Haranczyk, Haranczyk, Haranczyk, Haranczyk, Haranczyk, Haranczyk, Hendricks, Henkelman, Hert, Holliday, Humphrey, Kendall, Kendall, Li, Li, Mazurkiewicz, Messer, Periquet, Ptasinska, Sanville, Seidel, Straatsma, Taylor, Tonzani, Wesolowski, Willett, Zakjevskii   +42 more
core   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Explorando produtos naturais microbianos nas fronteiras da Química e da Biologia

Química Nova, 2013
The chemistry of natural products has been remarkably growing in the past few decades in Brazil. Aspects related to the isolation and identification of new natural products, as well as their biological activities, have been achieved in different ...
Luciana Gonzaga de Oliveira, Mônica Tallarico Pupo, Paulo Cezar Vieira   +2 more
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Virtual Ligand Screening for Structure-based Drug Design: Approaches and Progress [PDF]

Bioautomation, 2007
Recent progress in human genomics and proteomics has significantly increased the number of macromolecular targets potentially involved in drug discovery campaigns.
Olivier Sperandio, Maria A. Miteva, Bruno O. Villoutreix   +2 more
doaj  

A rapid screening, “combinatorial-type” survey of the metalloligand chemistry of Pt₂(PPh₃)₄(μ-S)₂ using electrospray mass spectrometry [PDF]

, 2001
Electrospray mass spectrometry is a rapid and powerful technique for a combinatorial-like survey of the chemistry of the metalloligand Pt₂(PPh₃)₄(μ-S)₂, leading to the successful isolation and crystallographic characterisation of the novel protonated ...
Fong, S.W. Audi, Henderson, William, Hor, T.S. Andy, Oliver, Allen G., Rickard, Clifton E.F., Vittal, Jagadese J.   +5 more
core   +2 more sources

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Single Domain Antibodies as New Biomarker Detectors

Diagnostics, 2017
Biomarkers are defined as indicators of biological processes, pathogenic processes, or pharmacological responses to a therapeutic intervention. Biomarkers have been widely used for early detection, prediction of response after treatment, and for ...
Chiuan Herng Leow, Katja Fischer, Chiuan Yee Leow, Qin Cheng, Candy Chuah, James McCarthy   +5 more
doaj   +1 more source

Rapid Quantification of Molecular Diversity for Selective Database Acquisition [PDF]

, 1997
There is an increasing need to expand the structural diversity of the molecules investigated in lead-discovery programs. One way in which this can be achieved is by acquiring external datasets that will enhance an existing database.
Ash J. E., Ashton M. J., Barnard J. M., Basak S. C., Basak S. C., Boyd S. M., David B. Turner, Downs G. M., Downs G. M., Holliday J. D., Hu C.-Y., Kearsley S. K., Martin E. J., Martin Y. C., Nilakantan R., Peter Willett, Shemetulskis N. E., Simon M. Tyrrell, Voorhees E. M, Willett P.   +19 more
core   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source